Changes in Vitamin D Supplement Use and Baseline Plasma 25-Hydroxyvitamin D Concentration Predict 5-y Change in Concentration in Postmenopausal Women

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography mass spectrometry, and information on supplement use was assessed from questionnaires. Seasonal variations in 25(OH)D concentrations were evaluated graphically and descriptively, and status according to age, sex, and supplement use was described. It was found that 86% of both adults and children were vitamin D-sufficient in either spring and or/autumn; however, many had a spring concentration below 50 nmol/L. A wide range of 25(OH)D concentrations were found in spring and autumn, with very low and very high values in both seasons. Among adults, women in general had higher median 25(OH)D concentrations than men. Furthermore, vitamin D supplement use was substantial and affected the median concentrations markedly, more so during spring than autumn. Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population.

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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Nutrients ◽

10.3390/nu12092742 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2742 ◽

Cited By ~ 1

Author(s):

Sarah Hakeem ◽

Nuno Mendonca ◽

Terry Aspray ◽

Andrew Kingston ◽

Carmen Ruiz-Martin ◽

...

Keyword(s):

Vitamin D ◽

Cognitive Status ◽

Vitamin D Status ◽

Very Old ◽

Old Adults ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Major Predictor ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

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Vitamin D deficiency prevalence and risk factors among pregnant Chinese women

Public Health Nutrition ◽

10.1017/s1368980015002980 ◽

2015 ◽

Vol 20 (10) ◽

pp. 1746-1754 ◽

Cited By ~ 18

Author(s):

Chunfeng Yun ◽

Jing Chen ◽

Yuna He ◽

Deqian Mao ◽

Rui Wang ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Chinese Women ◽

Sun Exposure ◽

Regression Analyses ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

AbstractObjectiveTo evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women.DesignA descriptive cross-sectional analysis.SettingChina National Nutrition and Health Survey (CNNHS) 2010–2013.SubjectsA total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses.ResultsThe median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007).ConclusionsVitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.

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Chemotherapy and vitamin D supplement use are determinants of serum 25-hydroxyvitamin D levels during the first six months after colorectal cancer diagnosis

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2020.105577 ◽

2020 ◽

Vol 199 ◽

pp. 105577 ◽

Cited By ~ 3

Author(s):

Evertine Wesselink ◽

Martijn J.L. Bours ◽

Johannes H.W. de Wilt ◽

Michiel Aquarius ◽

Stephanie O. Breukink ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cancer Diagnosis ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

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Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients

British Journal Of Nutrition ◽

10.1017/s0007114599000264 ◽

1999 ◽

Vol 81 (2) ◽

pp. 133-137 ◽

Cited By ~ 30

Author(s):

Elisabetta Romagnoli ◽

Patrizia Caravella ◽

Liliana Scarnecchia ◽

Paolo Martinez ◽

Salvatore Minisola

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Postmenopausal Women ◽

Healthy Subjects ◽

Hypovitaminosis D ◽

Hospitalized Patients ◽

Italian Population ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Group D

The present study aimed to investigate the prevalence and seasonal variation of hypovitaminosis D (defined as serum 25-hydroxyvitamin D level below 30 nmol/l) among healthy subjects and hospitalized patients living in central Italy. We studied 297 subjects, 131 in February 1997 and 166 in July 1997, subdivided into four groups: (a) young healthy blood donors; (b) healthy postmenopausal women; (c) inpatients with various medical diseases and (d) inpatients engaged in long-term rehabilitation programmes because of various neurological disorders. In all subjects and patients serum levels of 25-hydroxyvitamin D were measured by radioimmunoassay. We found a significant seasonal variation (P< 0·0001) of serum 25-hydroxyvitamin D levels, mean values being higher in summer in all groups, except in patients with a longer hospitalization time (group (d)). In each group, a significantly higher prevalence of hypovitaminosis D was found in winter compared with summer time (P< 0·001), being unexpectedly high in postmenopausal women (winter 32 % and summer 4·5 %); furthermore, in both seasons, inpatients were characterized by the highest incidences of hypovitaminosis, particularly those in group (d) (winter 82·3 % and summer 57·8 %). The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

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Prolonged treatment with vitamin D in postmenopausal women with primary hyperparathyroidism

Endocrine Connections ◽

10.1530/ec-12-0008 ◽

2012 ◽

Vol 1 (1) ◽

pp. 13-21 ◽

Cited By ~ 12

Author(s):

Ranganathan R Rao ◽

Harpal S Randeva ◽

Sailesh Sankaranarayanan ◽

Murthy Narashima ◽

Matthias Möhlig ◽

...

Keyword(s):

Vitamin D ◽

Primary Hyperparathyroidism ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Prolonged Treatment ◽

Serum 25Ohd ◽

Hydroxyvitamin D ◽

Significant Difference ◽

25 Hydroxyvitamin D ◽

Serum Pth

Introduction/backgroundVitamin D deficiency further increases circulating parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism (pHPT), with potential detrimental effects on bone mass.MethodsThis was an observational clinical study in consecutive conservatively treated postmenopausal women (n=40) with pHPT and coexistent 25-hydroxyvitamin D deficiency (25OHD ≤50 nmol/l (≤20 ng/ml)). Patients who showed an increase in serum 25OHD above the threshold of vitamin D deficiency (>50 nmol/l; n=28) using treatment with various commonly prescribed vitamin D preparations were, for the purposes of statistical analyses, allocated to the treatment group. Patients who were retrospectively identified as having received no treatment with vitamin D and/or remained vitamin D deficient were considered as non-responders/controls (n=12). Adjusted calcium (adjCa), PTH and 25OHD concentrations were monitored in all subjects up to 54 months (mean observation period of 18±2 months).ResultsProlonged increased vitamin D intake, regardless of the source (serum 25OHD, increase from 32.2±1.7 nmol/l at baseline to 136.4±11.6 nmol/l, P<0.0001), significantly reduced serum PTH (13.3±1.1 vs 10.5±1.0 pmol/l, P=0.0001), with no adverse effects on adjCa levels (2.60±0.03 vs 2.60±0.02 mmol/l, P=0.77) and renal function tests (P>0.73). In contrast, serum PTH remained unchanged (15.8±2.6 vs 16.3±1.9 pmol/l, P=0.64) in patients who remained vitamin D deficient, with a significant difference between groups in changes of PTH (P=0.0003). Intrapartial correlation analyses showed an independent negative correlation of changes in 25OHD with PTH levels (ric=−0.41, P=0.014).ConclusionsProlonged treatment with vitamin D in various commonly prescribed preparations appeared to be safe and significantly reduced PTH levels by 21%.

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25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women

Maturitas ◽

10.1016/j.maturitas.2010.10.006 ◽

2011 ◽

Vol 68 (1) ◽

pp. 73-78 ◽

Cited By ~ 18

Author(s):

Rowan T. Chlebowski ◽

Karen C. Johnson ◽

Dorothy Lane ◽

Mary Pettinger ◽

Charles L. Kooperberg ◽

...

Keyword(s):

Vitamin D ◽

Postmenopausal Women ◽

Hydroxyvitamin D ◽

Vitamin D Intake ◽

Joint Symptoms ◽

25 Hydroxyvitamin D

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Development and validation of an interview-administered FFQ for assessment of vitamin D and calcium intakes in Finnish women

British Journal Of Nutrition ◽

10.1017/s0007114515005474 ◽

2016 ◽

Vol 115 (6) ◽

pp. 1100-1107 ◽

Cited By ~ 8

Author(s):

Suvi T. Itkonen ◽

Maijaliisa Erkkola ◽

Essi Skaffari ◽

Pilvi Saaristo ◽

Elisa M. Saarnio ◽

...

Keyword(s):

Vitamin D ◽

Food Groups ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Food Records ◽

Supplemental Vitamin ◽

25 Hydroxyvitamin D ◽

Mean Differences ◽

Development And Validation ◽

Supplement Intake

AbstractIncreased vitamin D fortification of dairy products has increased the supply of vitamin D-containing products with different vitamin D contents on the market in Finland. The authors developed a ninety-eight-item FFQ with eight food groups and with a question on supplementation to assess dietary and supplemental vitamin D and Ca intakes in Finnish women (60ºN). The FFQ was validated in subgroups with different habitual vitamin D supplement use (0–57·5 µg/d) against the biomarker serum 25-hydroxyvitamin D (S-25(OH)D) and against 3-d food records (FR) (n29–67). Median total vitamin D intake among participants was 9·4 (range 1·6–30·5) µg/d. Spearman’s correlations for vitamin D and Ca ranged from 0·28 (P0·146, FFQv. S-25(OH)D, persons not using supplements) to 0·75 (P<0·001, FFQv. FR, supplement use included). The correlations between the FFQ and S-25(OH)D concentrations improved within increasing supplement intake. The Bland–Altman analysis showed wide limits of agreement between FFQ and FR: for vitamin D between −7·8 and 8·8 µg/d and for Ca between −938 and 934 mg/d, with mean differences being 0·5 µg/d and 2 mg/d, respectively. The triads method was used to calculate the validity coefficients of the FFQ for vitamin D, resulting in a mean of 1·00 (95 % CI 0·59, 1·00) and a range from 0·33 to 1·00. The perceived variation in the estimates could have been avoided with a longer FR period and larger number of participants. The results are comparable with earlier studies, and the FFQ provides a reasonable estimation of vitamin D and Ca intakes.

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Typical Prenatal Vitamin D Supplement Intake Does Not Prevent Decrease of Plasma 25-Hydroxyvitamin D at Birth

Journal of the American College of Nutrition ◽

10.1080/07315724.2013.879843 ◽

2014 ◽

Vol 33 (5) ◽

pp. 394-399 ◽

Cited By ~ 5

Author(s):

Marlies K. Ozias ◽

Elizabeth H. Kerling ◽

Danielle N. Christifano ◽

Susan A. Scholtz ◽

John Colombo ◽

...

Keyword(s):

Vitamin D ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement ◽

Supplement Intake

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Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model

Medicina ◽

10.3390/medicina55060265 ◽

2019 ◽

Vol 55 (6) ◽

pp. 265 ◽

Cited By ~ 1

Author(s):

Egidijus Šimoliūnas ◽

Ieva Rinkūnaitė ◽

Živilė Bukelskienė ◽

Virginija Bukelskienė

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Delivery Systems ◽

Oral Vitamin ◽

Medical Testing ◽

Laboratory Rats ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Oral Supplements ◽

Vitamin D Supplement

Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based. Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D3, the second—oil-based vitamin D3, and the third—micellized vitamin D3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day. Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D3 vehicles were the most bioavailable in comparison to micellized vitamin D3. Even more, the effect of the microencapsulated form of vitamin D3 remained constant for the longest period (up to 14 days). Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.

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