Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cells

2019 ◽  
Vol 95 (6) ◽  
pp. 667-679 ◽  
Author(s):  
Kumari Anuja ◽  
Amit Roy Chowdhury ◽  
Arka Saha ◽  
Souvick Roy ◽  
Arabinda Kumar Rath ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response ◽  
Radiation Induced

scholarly journals Deficiency of 15-LOX-1 Induces Radioresistance through Downregulation of MacroH2A2 in Colorectal Cancer

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1776 ◽  
Author(s):  
Yoo Jin Na ◽  
Bo Ram Kim ◽  
Jung Lim Kim ◽  
Sanghee Kang ◽  
Yoon A. Jeong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Specific Treatment ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Patient Specific ◽  
Histone H2a ◽  
Gene Set Enrichment ◽  
Damage Response ◽  
Radiation Induced

Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient-specific treatment. Arachidonate 15-lipoxygenase (15-LOX-1) enzyme is involved in polyunsaturated fatty acid metabolism. When colorectal cancer (CRC) cells were exposed to radiation, 15-LOX-1 was upregulated. To verify whether 15-LOX-1 protects against or induces DNA damage, we irradiated sh15-LOX-1 stable cells. We found that low 15-LOX-1 is correlated with radioresistance in CRC cells. These data suggest that the presence of 15-LOX-1 can be used as a marker for radiation-induced DNA damage. Consistent with this observation, gene-set-enrichment analysis based on microarray experiments showed that UV_RESPONSE was decreased in sh15-LOX-1 cells compared to shCon cells. Moreover, we discovered that the expression of the histone H2A variant macroH2A2 was sevenfold lower in sh15-LOX-1 cells. Overall, our findings present mechanistic evidence that macroH2A2 is transcriptionally regulated by 15-LOX-1 and suppresses the DNA damage response in irradiated cells by delaying H2AX activation.

scholarly journals Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

2014 ◽  
Vol 110 (4) ◽  
pp. 1014-1026 ◽  
Author(s):  
L Chen ◽  
L Fu ◽  
X Kong ◽  
J Xu ◽  
Z Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Stat3 Pathway ◽  
Damage Response

Ionizing radiation-induced DNA damage response identified in marine mussels, Mytilus sp.

2012 ◽  
Vol 168 ◽  
pp. 107-112 ◽  
Author(s):  
Ohoud D. AlAmri ◽  
Andrew B. Cundy ◽  
Yanan Di ◽  
Awadhesh N. Jha ◽  
Jeanette M. Rotchell
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Dna Damage Response ◽  
Damage Response ◽  
Marine Mussels ◽  
Radiation Induced

scholarly journals Correction: Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

Oncotarget ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 302-303
Author(s):  
Jie Zhang ◽  
Pengxing He ◽  
Yong Xi ◽  
Meiyu Geng ◽  
Yi Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Dna Damage Response ◽  
Down Regulation ◽  
Colorectal Cancer Cells ◽  
Damage Response

scholarly journals UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response

Oncotarget ◽  
2016 ◽  
Vol 7 (28) ◽  
pp. 44113-44128 ◽  
Author(s):  
Michele Signore ◽  
Mariachiara Buccarelli ◽  
Emanuela Pilozzi ◽  
Gabriele De Luca ◽  
Marianna Cappellari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0197154 ◽  
Author(s):  
Ftoon Aljarbou ◽  
Nourah Almousa ◽  
Mohammad Bazzi ◽  
Sooad Aldaihan ◽  
Mohammed Alanazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Telomere Length ◽  
Dna Damage Response ◽  
Damage Response ◽  
Related Proteins ◽  
Saudi Patients
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