Skeletal muscle strength in patients with cystic fibrosis

2001 ◽  
Vol 17 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Wietze de Jong ◽  
Wim M. C. van Aalderen ◽  
Jan Kraan ◽  
Gerard H. Koëter ◽  
Cees P. van der Schans
2012 ◽  
Vol 11 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Jason Wieboldt ◽  
Louis Atallah ◽  
Julia L. Kelly ◽  
Dinesh Shrikrishna ◽  
Khin M. Gyi ◽  
...  

2016 ◽  
Vol 17 (3) ◽  
pp. 497-510 ◽  
Author(s):  
Michael McLeod ◽  
Leigh Breen ◽  
D. Lee Hamilton ◽  
Andrew Philp

2011 ◽  
Vol 31 (2) ◽  
pp. 111-119 ◽  
Author(s):  
Jonathan Singer ◽  
Edward H. Yelin ◽  
Patricia P. Katz ◽  
Gabriela Sanchez ◽  
Carlos Iribarren ◽  
...  

2017 ◽  
Vol 15 (6) ◽  
pp. 434-439 ◽  
Author(s):  
Gao-feng Zhu ◽  
Zhi-fang Shen ◽  
Qing-he Shen ◽  
Yue-qin Jin ◽  
Zhi-yong Lou

2007 ◽  
Vol 117 (1) ◽  
pp. 277-277
Author(s):  
Foteini Mourkioti ◽  
Paschalis Kratsios ◽  
Tom Luedde ◽  
Yao-Hua Song ◽  
Patrick Delafontaine ◽  
...  

2015 ◽  
Vol 100 (4) ◽  
pp. 1654-1663 ◽  
Author(s):  
Brian A. Irving ◽  
Ian R. Lanza ◽  
Gregory C. Henderson ◽  
Rajesh R. Rao ◽  
Bruce M. Spiegelman ◽  
...  

Context: Skeletal muscle from sedentary older adults exhibits reduced mitochondrial abundance and oxidative capacity. Objective: The primary objective was to determine whether 8 weeks of combined training (CT) has a more robust effect than endurance training (ET) or resistance training (RT) on mitochondrial physiology in healthy young (18–30 years) and older (≥65 years) adults. Intervention: Thirty-four young and 31 older adults were randomly assigned to 8 weeks of ET, RT, and control/CT. Control subjects completed 8 weeks of no exercise (control) followed by 8 weeks of CT. Body composition, skeletal muscle strength, and peak oxygen uptake were measured before and after the intervention. Vastus lateralis muscle biopsy samples were obtained before and 48 hours after the intervention. Mitochondrial physiology was evaluated by high-resolution respirometry and expression of mitochondrial proteins and transcription factors by quantitative PCR and immunoblotting. Results: ET and CT significantly increased oxidative capacity and expression of mitochondrial proteins and transcription factors. All training modalities improved body composition, cardiorespiratory fitness, and skeletal muscle strength. CT induced the most robust improvements in mitochondria-related outcomes and physical characteristics despite lower training volumes for the ET and RT components. Importantly, most of the adaptations to training occurred independent of age. Conclusion: Collectively, these results demonstrate that both ET and CT increase muscle mitochondrial abundance and capacity although CT induced the most robust improvements in the outcomes measured. In conclusion, CT provides a robust exercise regimen to improve muscle mitochondrial outcomes and physical characteristics independent of age.


2003 ◽  
Vol 95 (4) ◽  
pp. 1379-1384 ◽  
Author(s):  
Sinead C. Barry ◽  
Charles G. Gallagher

Patients with cystic fibrosis (CF) have reduced peripheral muscle strength. We tested the hypothesis that steroid treatment contributes to muscle weakness in adults with CF. Twenty-three stable CF patients were studied. Measurements included knee extensor (KE), knee flexor (KF), elbow flexor (EF), handgrip (HG), expiratory (Pemax), and inspiratory (Pimax) muscle strengths. Spirometry, body mass index (BMI), and days spent in hospital over the preceding 12 mo (DH) were also measured. Average daily dose of prednisolone over the preceding 12 mo (ADD) was 5.1 mg/day. Pearson's correlation analysis revealed that ADD correlated significantly with skeletal muscle strengths (KF%, r = -0.63, P < 0.01) with the exception of HG%. These findings are independent of age, BMI, pulmonary function, and DH. Multiple-regression analysis revealed that ADD was the most significant predictor of all measures of skeletal muscle function except HG%. It was independently responsible for 54% of the variance in Pimax%, for 46% of the variance in Pemax%, for 45% of the variance in KE%, for 39% of the variance in KF%, and for 41% of the variance in EF%. Concomitant medications (e.g., theophylline) were shown to have no causative effect. Corticosteroids contribute to the skeletal muscle weakness seen in CF patients. The correlation of proximal muscle strength, but not HG strength, with steroid dosage further supports a cause-effect relationship.


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