scholarly journals Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

2007 ◽  
Vol 117 (1) ◽  
pp. 277-277
Author(s):  
Foteini Mourkioti ◽  
Paschalis Kratsios ◽  
Tom Luedde ◽  
Yao-Hua Song ◽  
Patrick Delafontaine ◽  
...  
2016 ◽  
Vol 17 (3) ◽  
pp. 497-510 ◽  
Author(s):  
Michael McLeod ◽  
Leigh Breen ◽  
D. Lee Hamilton ◽  
Andrew Philp

2011 ◽  
Vol 31 (2) ◽  
pp. 111-119 ◽  
Author(s):  
Jonathan Singer ◽  
Edward H. Yelin ◽  
Patricia P. Katz ◽  
Gabriela Sanchez ◽  
Carlos Iribarren ◽  
...  

2017 ◽  
Vol 15 (6) ◽  
pp. 434-439 ◽  
Author(s):  
Gao-feng Zhu ◽  
Zhi-fang Shen ◽  
Qing-he Shen ◽  
Yue-qin Jin ◽  
Zhi-yong Lou

2015 ◽  
Vol 100 (4) ◽  
pp. 1654-1663 ◽  
Author(s):  
Brian A. Irving ◽  
Ian R. Lanza ◽  
Gregory C. Henderson ◽  
Rajesh R. Rao ◽  
Bruce M. Spiegelman ◽  
...  

Context: Skeletal muscle from sedentary older adults exhibits reduced mitochondrial abundance and oxidative capacity. Objective: The primary objective was to determine whether 8 weeks of combined training (CT) has a more robust effect than endurance training (ET) or resistance training (RT) on mitochondrial physiology in healthy young (18–30 years) and older (≥65 years) adults. Intervention: Thirty-four young and 31 older adults were randomly assigned to 8 weeks of ET, RT, and control/CT. Control subjects completed 8 weeks of no exercise (control) followed by 8 weeks of CT. Body composition, skeletal muscle strength, and peak oxygen uptake were measured before and after the intervention. Vastus lateralis muscle biopsy samples were obtained before and 48 hours after the intervention. Mitochondrial physiology was evaluated by high-resolution respirometry and expression of mitochondrial proteins and transcription factors by quantitative PCR and immunoblotting. Results: ET and CT significantly increased oxidative capacity and expression of mitochondrial proteins and transcription factors. All training modalities improved body composition, cardiorespiratory fitness, and skeletal muscle strength. CT induced the most robust improvements in mitochondria-related outcomes and physical characteristics despite lower training volumes for the ET and RT components. Importantly, most of the adaptations to training occurred independent of age. Conclusion: Collectively, these results demonstrate that both ET and CT increase muscle mitochondrial abundance and capacity although CT induced the most robust improvements in the outcomes measured. In conclusion, CT provides a robust exercise regimen to improve muscle mitochondrial outcomes and physical characteristics independent of age.


Author(s):  
Rohit M. Sane ◽  
Pradeep R. Jadhav ◽  
Sanjana N. Subhedar

Abstract Background Caffeinated coffee, a psycho-stimulant, is widely consumed throughout the globe. However, its chronic consumption has deleterious effects on human health. Meanwhile, decaffeinated coffee has low content of caffeine and thus can be an alternative to caffeinated coffee. Therefore, the study was undertaken to explore and compare the acute effects of decaffeinated and caffeinated coffee on reaction time, mood and skeletal muscle strength in healthy volunteers. Methods This was a prospective, interventional, comparative type of study. The study included 70 healthy adults divided into two groups (Caffeinated coffee group and Decaffeinated coffee group). The following parameters were assessed: reaction time was assessed by digital display multiple-choice apparatus, mood by Visual Analogue Scale (VAS) and Profile of Mood States revised version (POMS) and skeletal muscle strength by hand dynamometer. All parameters in both groups were assessed pre-intervention (baseline) and 30 min post-intervention. Results In both groups (decaffeinated and caffeinated coffee) post-intervention, there was a statistically significant (p < 0.05) improvement in the reaction time (VRT) and mood (VAS, POMS) from the baseline. However, both groups did not show any significant effects on the skeletal muscle strength. Upon comparing the two groups, we found that caffeinated coffee showed higher and significant improvement of mood than decaffeinated coffee. Conclusions Decaffeinated coffee exerts an acute significant stimulatory effect on the reaction time and mood. However, these effects in comparison to caffeinated coffee are low. Further randomized control clinical trials are thus needed to validate these interesting findings.


2019 ◽  
Vol 35 (10) ◽  
pp. 1359-1365 ◽  
Author(s):  
Mike Pryzbek ◽  
Maureen MacDonald ◽  
Paul Stratford ◽  
Angelica McQuarrie ◽  
Julie Richardson ◽  
...  

2007 ◽  
Vol 104 (50) ◽  
pp. 20108-20113 ◽  
Author(s):  
O. Delbono ◽  
J. Xia ◽  
S. Treves ◽  
Z.-M. Wang ◽  
R. Jimenez-Moreno ◽  
...  

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