Probable role of induced lectins in capsule formation inSquilla mantis L.

BACKGROUND Scleroderma, when complicated with pulmonary hypertension (PHT), presents a worse prognosis; recently treatment with new drugs seems to offer good perspectives, especially in early diagnosis and treatment. The standard approach for diagnosing PHT consists in measurement of the pulmonary artery pressure (PAP) by means of echodoppler. AIM OF INVESTIGATION Aim of this work is evaluating the significance of the NT-proBNP parameter, matched to echodoppler, in diagnosing scleroderma PHT. MATERIALS AND METHODS Sixty (60) patients, who came to observation for progressive systemic sclerosis underwent echodoppler in order to measure the PAP (normal values up to 30 mmHg). NT-proBNP was determined on serum sample using ECLIA method by Modular E170 (Roche Diagnostics); manufacturer reference values for age and gender were used. Forty-three (43) patients underwent a further NT-proBNP sampling 5 days later in order to assess parameter stability. RESULTS PHT and non- PHT patients showed statistically different (p < 0,001) medians (126 vs 69 pg/ml). No pathologic values of NT-proBNP were measured in the group with PAP < 30 mmHg, while 27% of cases who had PAP between 30 and 40 showed pathologic concentrations. The positivity ratio increases to 57% in patients showing PAP > 40 mmHg. No relevant correlation (r = 0,2) was found between PAP and NT-proBNP. Mean average between the two sampling groups was 31%. CONCLUSIONS In scleroderma patients, combination of NT-proBNP and PAP seems to improve the diagnosis of pulmonary hypertension, especially in presence of borderline pulmonary pressure values. We therefore propose the biochemical observation of NT-proBNP when PAP is > 30 mmHg and in monitoring the evolution of the pathology.

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Spinal Tolerance and Dependence: Some Observations on the Role of SpinalN-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

Pain Research and Management ◽

10.1155/2000/514020 ◽

2000 ◽

Vol 5 (1) ◽

pp. 33-39

Author(s):

Tony L Yaksh ◽

Xiao-Ying Hua

Keyword(s):

Nmda Receptor ◽

Opioid Analgesic ◽

Dose Effect ◽

Concurrent Treatment ◽

Analgesic Effects ◽

Delta Opioids ◽

Probable Role ◽

Pkc Isozymes ◽

The Right

The continuous delivery of opiates can lead to a reduction in analgesic effects. In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component. Such loss of effect, deemed to be tolerance in the present article, can be readily demonstrated in animals with repeated bolus and continuous intrathecal infusion of mu and delta opioids and alpha-2 adrenergic agonists. Research has shown that this loss of effect can be diminished by concurrent treatment withN-methyl-D-aspartate (NMDA) receptor antagonists and by the suppression of the activity of spinal protein kinase C (PKC). This suggests in part the probable role of PKC-mediated phosphorylation in the right shift in the dose-effect curves observed with continuous opiate or adrenergic exposure. Importantly, this right shift is seen to occur in parallel with an increase in the phosphorylating activity in the dorsal horn and in the expression of several PKC isozymes. The target of this phosphorylation is not certain. Phosphorylation of the NMDA receptor enhances its functionality, while phosphorylation of the opioid receptor or associated channels seems to diminish their activity or to enhance internalization. While the focus is on several specific components, the accumulating data emphasize the biological complexity of these changes in spinal drug reactivity.

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STABILIZATION OF Bi(2223) SUPERCONDUCTING PHASE BY VANADIUM OXIDE ADDITION

International Journal of Modern Physics B ◽

10.1142/s0217979293000354 ◽

1993 ◽

Vol 07 (01n03) ◽

pp. 157-161 ◽

Cited By ~ 2

Author(s):

D. SURESH BABU ◽

G. NARSING RAO ◽

L. BROHAN ◽

M. GANNE

Keyword(s):

Critical Current Density ◽

Current Density ◽

Flux Pinning ◽

Volume Fraction ◽

Ac Susceptibility ◽

Superconducting Phase ◽

Nominal Composition ◽

Oxide Addition ◽

Probable Role

We report on the ac susceptibility, microwave absorption and dc magnetization of Bi 2− x V x Sr 2 Ca 2 Cu 3 O y (nominal composition). The low T c (2212) phase ( T c = 85 K ) dominates in the x = 0 sample with extremly weak flux pinning. In x = 0.4 sample, both flux pinning and volume fraction of the high T c (2223) phase ( T c = 105 K ) were increased. The intragrain critical current density of the sample with x = 0.4 was estimated and found to be comparable with that of Pb doped Bi 2 Sr 2 Ca 2 Cu 3 O y superconductor. The data suggest that addition of V 2 O 5 in Bi 2 Sr 2 Ca 2 Cu 3 O y system increases the volume fraction of the high T c phase. Probable role of vanadium in enhancing the high T c (2223) phase in Bi-V-Sr-Ca-Cu-O system is discussed.

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Genotype and within-pod bean position microenvironment effect on seed choice for raising cocoa (Theobroma cacao L.) seedlings

Acta agriculturae Slovenica ◽

10.14720/aas.2020.115.2.1345 ◽

2020 ◽

Vol 115 (2) ◽

pp. 247

Author(s):

Daniel B. ADEWALE ◽

Beatrice A. NDUKA

Keyword(s):

Biomass Yield ◽

Cocoa Bean ◽

Shoot Biomass ◽

Seedling Vigour ◽

Periodic Data ◽

Length Width ◽

Probable Role ◽

Number Of Leaves ◽

Theobroma Cacao L

<p>The probable role of within-pod microenvironment on seed sizes, seedling vigour and biomass yield of four cocoa genotypes was investigated for two years. The respective main, sub and sub-sub plots in the split-split plot experimental design were years, genotypes and within-pod bean positions. Data were taken on cocoa bean length, width and thickness after each pod was opened. Four weekly periodic data were obtained for plant height (PH), stem girth (SG) and number of leaves (NOL); root and shoot biomass yield were also recorded. Analysis of variance revealed significant (p ≤ 0.05) bean position, genotypes, years and some interaction on the studied traits. Means of the levels of the three factors differed significantly (p ≤ 0.05). Proximal, middle and distal positions were distinct within-pod microenvironments. The pod middle cavity housed the longest, widest and heaviest beans. Trend analysis of the growing sequences of NOL, PH and SG by the four genotypes differed with bean locations. For bean length, GGE biplot respectively identified CRIN Tc1, CRIN Tc2 and CRIN Tc3 as the best genotype for middle, proximal and the distal positions. The intra-locular space within the pod enhanced differential seed development and maturation; this was evident in the seedling vigour.</p>

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Epizootic Situation on Anaplasmosis of Small Ruminants in the Irkutsk Region

Acta biomedica scientifica ◽

10.29413/abs.2021-6.1.9 ◽

2021 ◽

Vol 6 (1) ◽

pp. 60-68

Author(s):

O. V. Suntsova ◽

V. A. Rar ◽

O. V. Lisak ◽

I. V. Meltsov ◽

E. K. Doroschenko ◽

...

Keyword(s):

Nucleotide Substitution ◽

Small Ruminants ◽

Wide Distribution ◽

Anaplasma Ovis ◽

Single Nucleotide ◽

Blood Samples ◽

Sheep Blood ◽

Irkutsk Region ◽

Probable Role

Anaplasmosis of ruminants is a group of natural focal infections caused by bacteria from the genus Anaplasma of the Anaplasmataceae family. The main etiological agent of anaplasmosis in sheep, goats, and wild ruminants is Anaplasma ovis, which parasitizes in the erythrocytes of these animals. The purpose of this study was the finding and identification of Anaplasma spp. in the blood of small ruminants using genetic methods and obtaining data on the distribution of anaplasmosis in the Irkutsk region. 20 goat blood samples, 611 sheep blood samples and 209 Dermacentor nuttalli ticks from 12 districts of the Irkutsk region were examined for the presence of Anaplasma spp. Only one type of anaplasma, A. ovis, was found among the genotyped samples. A. ovis was found in the blood of sheep and goats in all of the studied districts of the Irkutsk region. The proportion of sheep blood samples containing anaplasma DNA varied from 30 % to 85 %, in goats – from 10 % to 100 % in different districts, and averaged 57.8 % in sheep and 55,0 % in goats. Frequency of infection of D. nuttalli ticks with A. ovis was 5.7 %. The nucleotide sequences of the samples detected in the blood of small ruminants on the territory of the Irkutsk region differed from each other by a single nucleotide substitution and were identical to the sequences of the type strain Haibei, as well as the sequences of A. ovis previously found in the blood of sheep from Mongolia, deer from China, and Dermacentor niveus and Dermacentor nuttalli ticks from China. These sequences were also identical to the sequences previously found in the blood of sheep from Altai and in Dermacentor nuttalli ticks from Tuva, which indicates the wide distribution of these A. ovis genovariants in Siberia and the probable role of D. nuttalli as a carrier of the agent of anaplasmosis of small ruminants in the Irkutsk region.

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Epithelial—mesenchymal tissue interactions guiding otic capsule formation: the role of the otocyst

Development ◽

10.1242/dev.97.1.1 ◽

1986 ◽

Vol 97 (1) ◽

pp. 1-24

Author(s):

Joseph R. McPhee ◽

Thomas R. Van De Water

Keyword(s):

Mouse Embryo ◽

Mouse Embryos ◽

In Vitro Studies ◽

Otic Capsule ◽

Membranous Labyrinth ◽

Capsule Formation ◽

Tissue Interactions ◽

Mesenchymal Tissue

The otocyst is the epithelial anlage of the membranous labyrinth which interacts with surrounding cephalic mesenchyme to form an otic capsule. A series of in vitro studies was performed to gain a better understanding of the epithelial—mesenchymal interactions involved in this process. Parallel series of otocyst/mesenchyme (O/M) and isolated periotic mesenchyme (M) explants provided morphological and biochemical data to define the role of the otocyst in organizing and directing formation of its cartilaginous otic capsule. Explants were made from mouse embryos ranging in age from 10 to 14 days of gestation, and organ cultured under identical conditions until the chronological equivalent of 16 days of gestation. Expression of chrondrogenesis was determined by both histology and biochemistry. The in vitro behaviour of periotic mesenchyme explanted either with or without an otocyst supports several hypotheses that explain aspects of otic capsule development. The results indicate that (a) prior to embryonic day 12 the otocyst alone is not sufficient to stimulate chondrogenesis of the otic capsule within O/M explants; (b) the otocyst acts as an inductor of capsule chondrogenesis within O/M explants between embryonic days 12 to 13; (c) isolated mesenchyme within M explants taken from 13-day-old embryos are capable of initiating in vitro chondrogenesis, but without expressing capsule morphology in the absence of the otocyst; and (d) the isolated mesenchyme of M explants obtained from 14-day-old embryos expresses both chondrogenesis and otic capsule morphology in the absence of the otocyst. These findings suggest that the otocyst acts as an inductor of chondrogenesis of periotic mesenchyme tissue between embryonic days 11 to 13, and controls capsular morphogenesis between embryonic days 13 to 14 in the mouse embryo.

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The linguistic situation in the territory of Andalusia

Palaeohispanic Languages and Epigraphies ◽

10.1093/oso/9780198790822.003.0006 ◽

2019 ◽

pp. 138-159 ◽

Cited By ~ 1

Author(s):

J. de Hoz

Keyword(s):

Ethnic Groups ◽

Place Names ◽

Lingua Franca ◽

Personal Names ◽

Probable Role ◽

Cultural Role

In antiquity present-day Andalusia was occupied by several different peoples, among whom the main cultural role was taken by the Tartessians, subsequently the Turdetani. The first part of this chapter aims to define the limits and variety of the different ethnic groups. Thereafter, the material available to study the languages of the region is analysed: inscriptions, place names, and personal names. This material is limited and poses numerous problems, but it enables us to define linguistic zones, to emphasize the plurilingual nature of the area, to detect the probable role of Phoenician as a lingua franca, and to draw attention to certain features of Turdetanian, the most widely spoken of the vernacular languages of the region.

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A study of kidney lysosomal acid phosphatase during compensatory renal hyperplasia in rats

Canadian Journal of Zoology ◽

10.1139/z68-069 ◽

1968 ◽

Vol 46 (3) ◽

pp. 499-502 ◽

Cited By ~ 2

Author(s):

B. M. Hegdekar

Keyword(s):

Acid Phosphatase ◽

Lysosomal Enzymes ◽

Soluble Fraction ◽

Female Rats ◽

Enzyme Release ◽

Lysosomal Fraction ◽

Probable Role ◽

Long Evans ◽

Free Activity

Female rats of the Long-Evans hooded strain, 4–6 months old and weighing 275–300 grams, were subjected to unilateral nephrectomy and the acid phosphatase activity in the remaining kidney was studied at the end of 24, 48, 72 hours, and 8 days respectively. Most of the acid phosphatase was found in the particulate fraction in normal kidneys. The enzyme activity in the soluble fraction was found to have increased the second day after the operation, but decreased to the original level by the end of 72 hours. The free activity of the lysosomal fraction also increased by the end of second postoperative day. A change in the permeability of the lysosomal membrane before the enzyme release was observed. The probable role of lysosomal enzymes in the initiation of mitotic divisions during compensatory renal hyperplasia is discussed.

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ROLE OF THE THYROID GLAND IN REGULATION OF METABOLIC RATE IN AN AIR-BREATHING SILUROID FISH, HETEROPNEUSTES FOSSILIS (BLOCH)

Journal of Endocrinology ◽

10.1677/joe.0.0690421 ◽

1976 ◽

Vol 69 (3) ◽

pp. 421-425 ◽

Cited By ~ 8

Author(s):

B. N. PANDEY ◽

J. S. D. MUNSHI

Keyword(s):

Oxygen Consumption ◽

Thyroid Gland ◽

Metabolic Rate ◽

Seasonal Variations ◽

Heteropneustes Fossilis ◽

Cyclic Activity ◽

Experimental Conditions ◽

Probable Role ◽

Made In

SUMMARY Studies on cyclic activity of the thyroid and seasonal variations in oxygen consumption (V̇o2) under experimental conditions in which surfacing was either allowed or prevented were made in H. fossilis to try to establish a relationship between these measures and to ascertain the possible role of the thyroid in the regulation of metabolic rate. A good correlation was found between the activity of the thyroid and V̇o2 in this species. This finding was further confirmed by the administration of l-thyroxine or thiouracil to this fish. The thyroxine-and thiouracil-treated animals showed significantly higher (P < 0·05) and lower (P < 0·01) rates of V̇o2 respectively, thus indicating the probable role of the thyroid in the regulation of metabolic rate.

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