Bee bread attenuates high fat diet induced renal pathology in obese rats via modulation of oxidative stress, downregulation of NF-kB mediated inflammation and Bax signalling

2020 ◽  
pp. 1-17 ◽  
Author(s):  
Chinedum Eleazu ◽  
Joseph Bagi Suleiman ◽  
Zaidatul Akmal Othman ◽  
Zaida Zakaria ◽  
Victor Udo Nna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Renal Pathology ◽  
High Fat ◽  
Bee Bread ◽  
Obese Rats

scholarly journals Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats

Antioxidants ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 70 ◽  
Author(s):  
Cuauhtémoc Sandoval-Salazar ◽  
Cecilia Oviedo-Solís ◽  
Edmundo Lozoya-Gloria ◽  
Herlinda Aguilar-Zavala ◽  
Martha Solís-Ortiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Frontal Cortex ◽  
Protein Oxidation ◽  
High Fat Diet ◽  
High Fat ◽  
Gaba Concentration ◽  
Obese Rats ◽  
Lipid And Protein Oxidation

It has been proposed that there is a correlation between high-fat diet (HFD), oxidative stress and decreased γ-aminobutyric acid (GABA) levels, but this has not been thoroughly demonstrated. In the present study, we determined the effects of strawberry extract intake on the oxidative stress and GABA levels in the frontal cortex (FC) of obese rats. We observed that an HFD increased lipid and protein oxidation, and decreased GABA levels. Moreover, UV-irradiated strawberry extract (UViSE) decreased lipid peroxidation but not protein oxidation, whereas non-irradiated strawberry extract (NSE) reduced protein oxidation but not lipid peroxidation. Interestingly, NSE increased GABA concentration, whereas UViSE was not as effective. In conclusion, our results suggest that an HFD increases oxidative damage in the FC, whereas strawberry extract intake may ameliorate the disturbances associated with HFD-induced oxidative damage.

scholarly journals Cardiac tissue oxidative stress and inflammation after vitamin D administrations in high fat- diet induced obese rats

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Ghazaleh Nameni ◽  
Ghazaleh Hajiluian ◽  
Mehran Mesgari-Abbasi
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
High Fat Diet ◽  
Cardiac Tissue ◽  
High Fat ◽  
Obese Rats

scholarly journals Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats

2021 ◽  
Vol 2 (3) ◽  
pp. 39-50
Author(s):  
Abdel-Moniem A. Makhlouf ◽  
Atef M. Mahmoud ◽  
Rania G. Ibrahim ◽  
Yasmeen S. Abdel Aziz
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
High Fat Diet ◽  
Male Rats ◽  
Antioxidant Defenses ◽  
Control Group ◽  
High Fat ◽  
Stress Markers ◽  
Obese Rats ◽  
Markers Of Oxidative Stress

Purpose: This study was aimed to evaluate the antioxidant and anti-inflammatory effects of vitamin D and Simvastatin (SIM) on a high-fat diet (HFD) induced-obese rats. Methods: 40 adult male rats were divided into four groups: control group, HFD, HFD + vitamin D, and HFD + SIM for 14 weeks. Vitamin D or SIM supplementation was done for the last 6 weeks. Vitamin D dosage was 500 IU/kg, while SIM dosage was 10 mg/kg. Interleukin-6 (IL-6) concentration and markers of oxidative stress including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione(GSH) concentrations in serum were determined using ELISA kits and spectrophotometry methods, respectively. Results: Treatment with vitamin D or SIM could significantly reduce IL-6 and MDA and increases SOD, GPx activities, and GSH levels. Oxidative stress can result not only from increased ROS production but also from dysfunctional antioxidant defenses. Conclusion: From the experimental results, it was observed that SIM and vitamin D could attenuate oxidative stress and inflammation markers associated with obesity.

scholarly journals The Effects of Feeding Obese Rats by Bee Bread on IL-6 Expression in Rat Stomach

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1570
Author(s):  
Zuleyha Doganyigit ◽  
Birkan Yakan ◽  
Emin Kaymak
Keyword(s):  
Interleukin 6 ◽  
High Fat Diet ◽  
High Fat ◽  
Rat Stomach ◽  
Bee Bread ◽  
Obese Rats

The aim of this project was the determination of the effect of bee bread supplement in diets of obese rats on interleukin 6 immunreactivity. This study has been shown that bee bread against obesity with a high-fat diet reduces IL-6 expression in the stomach.

scholarly journals Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats

Antioxidants ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 33 ◽  
Author(s):  
Zaidatul Akmal Othman ◽  
Wan Syaheedah Wan Ghazali ◽  
Liza Noordin ◽  
Nurul Aiman Mohd. Yusof ◽  
Mahaneem Mohamed
Keyword(s):  
Phenolic Compounds ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Antioxidant Activities ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Sprague Dawley ◽  
High Fat ◽  
Bee Bread ◽  
Obese Rats

This study was undertaken to determine the phenolic compounds and the anti-atherogenic effect of bee bread in high-fat diet (HFD)-induced obese rats. The presence of phenolic compounds in bee bread was determined by liquid chromatography–mass spectrometry. Thirty-two male Sprague Dawley rats were divided into four groups, (n = 8/group); i.e., Normal (N), HFD (high-fat diet), HFD + BB (high-fat diet and 0.5 g/kg/day bee bread), and HFD + O (high-fat diet and 10 mg/kg/day orlistat) groups. After 6 weeks of the experiment, rats were sacrificed. Five phenolic compounds were identified in bee bread; namely, caffeic acid, ferulic acid, kaempferol, apigenin, and isorhamnetin. Bee bread significantly reduced Lee obesity index and levels of total cholesterol (TC), low-density lipoprotein (LDL), fatty acid synthase (FAS) activity, atherogenic index, oxidised-LDL (oxLDL), and malondialdehyde (MDA), and significantly increased aortic antioxidant activities, such as those of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Adipocyte sizes were found to be smaller in the HFD + BB group compared to the N group, and en face aortas showed an absence of atherosclerotic plaque in rats supplemented with bee bread. These changes might suggest an anti-atherogenic effect of bee bread in HFD-induced obese rats via its antioxidant and hypocholesterolaemic properties.

scholarly journals Anthocyanins from black wolfberry (Lycium ruthenicum Murr.) prevent inflammation and increase fecal fatty acid in diet-induced obese rats

RSC Advances ◽  
2017 ◽  
Vol 7 (75) ◽  
pp. 47848-47853 ◽  
Author(s):  
Jinjin Yin ◽  
Tao Wu
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
High Fat Diet ◽  
Sprague Dawley ◽  
High Fat ◽  
Sprague Dawley Rats ◽  
Lycium Ruthenicum ◽  
Obese Rats ◽  
Lycium Ruthenicum Murr ◽  
Obese Male

This study aimed to determine whether black wolfberry (Lycium ruthenicumMurr.) anthocyanin (BWA) consumption can alleviate oxidative stress and reduce inflammation in high-fat diet-induced obese male Sprague-Dawley rats.

scholarly journals Investigation of the relationship between oxidative stress andSCUBE1 levels in high fat diet-induced obese rats

2018 ◽  
Vol 48 ◽  
pp. 196-201
Author(s):  
Akın BODUR ◽  
Cemil KAHRAMAN ◽  
Diler US ALTAY ◽  
Taghi Ahmadi RENDI ◽  
Ahmet MENTEŞE ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats ◽  
The Relationship
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