The novel use of fertility quality of life (FertiQoL) treatment subscale to assess treatment acceptability in social egg freezing

2020 ◽  
pp. 1-9
Author(s):  
Benjamin Jones ◽  
Abirami Rajamanoharan ◽  
Lorraine Kasaven ◽  
Maria Jalmbrant ◽  
Joy Green ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Acceptability ◽  
The Novel ◽  
Egg Freezing ◽  
Social Egg Freezing

ДИАГНОСТИКА ХРОНИЧЕСКИХ ИНДУЦИРОВАННЫХ КРАПИВНИЦ

2019 ◽  
pp. 5-13
Author(s):  
E.Yu. Borzova
Keyword(s):  
Quality Of Life ◽  
Biological Therapy ◽  
Treatment Algorithm ◽  
The Novel ◽  
International Guidelines ◽  
Systemic Reactions ◽  
Significant Impairment ◽  
Challenge Tests

Хронические индуцированные крапивницы имеют важное социальноэкономическое значение вследствие риска развития системных реакций и значительного снижения качества жизни пациентов. Диагностика хронических индуцированных крапивниц основывается на анамнестических данных и проведении провокационных тестов. Современный протокол ведения больных хронической крапивницей включает применение неседативных антигистаминных препаратов. Международные согласительные документы по лечению крапивницы рекомендуют 4кратное увеличение суточной дозы неседативных антигистаминных препаратов при их неэффективности в стандартных дозах. Данные метаанализа указывают на эффективность омализумаба при хронических индуцированных крапивницах. В перспективе ожидается расширение арсенала генноинженерной биологической терапии хронических индуцированных крапивниц.Chronic inducible urticarias are characterized by the risks of systemic reactions and a significant impairment of patients quality of life. The diagnosis of chronic inducible urticarias relies on the patients history and the challenge tests. A treatment algorithm for the management of chronic inducible urticarias includes nonsedating antihistamines as a firstline treatment. The international guidelines for the management of chronic inducible urticarias recommend updosing of nonsedating antihistamines up to four fold if standard doses are not effective. The metaanalysis suggests the efficacy of omalizumab in chronic inducible urticarias. In the prospect, the novel options of biological therapy for chronic inducible urticarias are expected.

scholarly journals Development and Validation of a Questionnaire Evaluating the Impact of Prosthetic Dental Treatments on Patients’ Oral Health Quality of Life: A Prospective Pilot Study

2020 ◽  
Vol 17 (14) ◽  
pp. 5037 ◽  
Author(s):  
Eitan Mijiritsky ◽  
Yael Lerman ◽  
Ori Mijiritsky ◽  
Asaf Shely ◽  
Joseph Meyerson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Pilot Study ◽  
Post Treatment ◽  
Self Report ◽  
Measurement Tool ◽  
The Novel ◽  
Prospective Pilot Study ◽  
The Impact

Objectives: the aims of this study were the development of a novel questionnaire to assess the impact of prosthetic treatments on oral health-related quality of life (OHRQoL) and the performance of a prospective pilot study. Background: the currently preferred OHRQoL measurement tool is the oral health impact profile-49 (OHIP-49), a self-report questionnaire which mainly focuses on general effects related to oral health. Materials and methods: A total of 24 adult participants (9 females and 15 males) were recruited and asked to complete the novel questionnaire twice: once before the prosthetic treatment began and 4–6 weeks post-treatment. The assessment of the change in OHRQoL was based on the differences in participants’ answers before and after treatment. Data were analyzed using ANOVA with a repeated-measures method and t-tests. The reliability of the questionnaire was tested using Cronbach’s alpha and intraclass coefficient (ICC). Results: The questionnaire was found to be reliable (α ≥ 0.6), with “social disability” having the highest score (α = 0.868). All domains showed an improvement (α < 0.005) in OHRQoL scores after treatment. Conclusions: the novel questionnaire tested in this study was found to be reliable and convenient to use, and demonstrated that prosthetic treatments have a significant positive effect on OHRQoL post-treatment scores.

Emancipation on thin ice : Women’s autonomy, reproductive justice, and social egg freezing

2019 ◽  
Vol 22 (4) ◽  
pp. 357-371
Author(s):  
Michiel De Proost ◽  
Gily Coene
Keyword(s):  
Critical Analysis ◽  
Gender Inequalities ◽  
Reproductive Justice ◽  
Reproductive Autonomy ◽  
Quality Of Treatment ◽  
Intersectional Analysis ◽  
And Gender ◽  
Egg Freezing ◽  
Social Egg Freezing

Abstract A growing number of women in different countries are freezing their eggs as a way to preserve fertility not just for medical reasons, but for what have been referred to as ‘lifestyle’ or ‘social’ reasons. Ethical debates so far have often focused on reproductive autonomy and gender inequalities in society. Based on a critical analysis of the available studies that explore women’s experiences, we conclude that women’s choice to freeze their eggs is much more ambiguous than mainstream approaches to bioethics usually suggest. Furthermore, we point to a gap in the literature of social egg freezing regarding issues of reproductive justice, including the multiple and intersecting structural conditions that govern who has access to this technology, and tease out some issues that still need to be further explored, such as the outcomes and quality of treatment for non-normative users. Expanding the debate with an intersectional analysis makes visible, as we demonstrate, how techniques such as social egg freezing fit into, and contribute to the propagation of, neoliberal gendered, heteronormative, and racialised societies.

Hyperbaric oxygenation in the implementation of rehabilitation measures after COVID-19 pneumonia

2021 ◽  
pp. 7-11
Author(s):  
Tatyana Nikolaevna Kondratyeva ◽  
Natalya Alekseevna Kutalova
Keyword(s):  
Quality Of Life ◽  
Hyperbaric Oxygenation ◽  
The Body ◽  
The Novel ◽  
Complex Treatment ◽  
Coronavirus Infection ◽  
Rehabilitation Measures ◽  
Novel Coronavirus ◽  
The Impact

The aim of the study was to research the hyperbaric oxygenation effect on the condition of patients in the course of complex treatment aimed at rehabilitation after suffering from COVID-19 pneumonia. Results: the impact of hyperbaric oxygenation on the body of patients who have suffered from the novel coronavirus infection provides a positive dynamics and improves their quality of life. Conclusion: in the process of rehabilitating patients who have undergone the new coronavirus infection, it is necessary to use various physiotherapeutic measures, including hyperbaric oxygenation.

scholarly journals Novel strategies and therapeutic options for the management of primary biliary cholangitis

2017 ◽  
Vol 10 (10) ◽  
pp. 791-803 ◽  
Author(s):  
Amardeep Khanna ◽  
David E. Jones
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Review Article ◽  
Primary Biliary Cholangitis ◽  
Pharmaceutical Companies ◽  
The Novel ◽  
Aggressive Disease ◽  
Therapeutic Molecules ◽  
Novel Therapeutic

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. It has a varied course of progression ranging from being completely asymptomatic to aggressive disease leading to cirrhosis and resulting in liver transplantation. In addition, symptoms can be debilitating and can have a major impact on quality of life. For decades, there was only one anti-cholestatic agent available to target this disease and that was only effective in around half of patients, with little or no effect on symptoms. With increasing understanding of the pathogenic mechanisms of PBC and potential targets for drug treatment, pharmaceutical companies have shown a greater interest in this rare disease. A large number of novel therapeutic molecules have been developed and are currently being evaluated. In this review article all the novel molecules in use and in trials targeting cholestasis and symptoms in PBC are discussed.

Beyond individualisation: towards a more contextualised understanding of women’s social egg freezing experiences

2021 ◽  
pp. medethics-2020-107190
Author(s):  
Michiel De Proost ◽  
Gily Coene ◽  
Julie Nekkebroeck ◽  
Veerle Provoost
Keyword(s):  
Critical Discussion ◽  
Relationship Formation ◽  
Normative Claim ◽  
Quality Of Information ◽  
Ethical Concerns ◽  
Societal Challenges ◽  
Qualitative Interview Study ◽  
Egg Freezing ◽  
Social Egg Freezing

Recently, Petersen provided in this journal a critical discussion of individualisation arguments in the context of social egg freezing. This argument underlines the idea that it is morally problematic to use individual technological solutions to solve societal challenges that women face. So far, however, there is a lack of empirical data to contextualise his central normative claim that individualisation arguments are implausible. This article discusses an empirical study that supports a contextualised reading of the normative work of Petersen. Based on a qualitative interview study, we found that most women could make sense of this argument but addressed other concerns that are overlooked in the premises of moral individualisation arguments, for instance, the influence of relationship formation on the demand of egg freezing. Furthermore, women did not experience social egg freezing as morally problematic. Nonetheless, the interviewees pointed to a need of more societal solutions and even actively advocated for efforts to increase accessibility such as a partial reimbursement and better quality of information. The implications of these findings for empirical bioethics are discussed. While more research is needed, we argue that, in order to better address individualisation arguments and related ethical concerns, we need to contextualise normative evaluations within women’s moral reasoning.

scholarly journals Does coronavirus pose a challenge to the diagnoses of anxiety and depression? A view from psychiatry

2020 ◽  
pp. 1-3 ◽  
Author(s):  
Lynne M. Drummond
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Depressive Symptoms ◽  
Anxiety Disorder ◽  
Anxiety And Depression ◽  
The Novel ◽  
Novel Coronavirus ◽  
Pathological Anxiety

Some authors have suggested that the emergence of the novel coronavirus, SARS-CoV-2, and the subsequent pandemic has meant that the constructs of pathological anxiety and depression are meaningless owing to widespread anxiety and depressive symptoms. This paper examines what is required to make a diagnosis of a depressive or anxiety disorder and how this may differ from fleeting symptomatology in response to specific situations or stimuli. All people experience the emotions of both anxiety and depression, but far fewer have a persistent anxiety or depressive syndrome which interferes with their quality of life and functioning. The pandemic and its issues are then discussed, and existing studies examining the reactions of people living through the pandemic are presented. Finally, the paper examines possible ways to cope at times of increased stress and how we can try to protect ourselves from long-term mental health sequelae of chronic stress.

scholarly journals Comparing Mental Health During the COVID-19 Lockdown and 6 Months After the Lockdown in Austria: A Longitudinal Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Christoph Pieh ◽  
Sanja Budimir ◽  
Elke Humer ◽  
Thomas Probst
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Longitudinal Study ◽  
Perceived Stress ◽  
Well Being ◽  
Effect Sizes ◽  
The Novel ◽  
Novel Coronavirus ◽  
Insomnia Symptoms

The novel coronavirus disease (COVID-19) has repeatedly been reported to impair mental health. This longitudinal study evaluated mental health at the emergence of the COVID-19 pandemic (t1) and 6 months later (t2) in Austria. Indicators of mental health were depression (PHQ-9), anxiety (GAD-7), sleep quality (ISI), perceived stress (PSS-10), as well as quality of life (WHO-QOL BREF) and well-being (WHO-5). In total, N = 437 individuals participated in both surveys (52.9% women). The number of participants with clinically relevant depressive, anxiety, or insomnia symptoms did not differ statistically significantly between t1 and t2 (p ≥ 0.48). The prevalence of moderate or severe (clinically relevant) (1) depressive symptoms changed from 18.3% to 19.7% (p = 0.48), (2) anxiety symptoms from 16.5 to 15.6% (p = 0.67), and insomnia from 14.6 to 15.6% (p = 0.69) from t1 to t2. Bonferroni-corrected t-tests showed that the stress level (PSS-10) decreased, and well-being (WHO-5) increased. However, effect sizes do not seem to be clinically relevant (Cohen‘s d &lt; 0.2). Results suggest that detrimental health consequences of the COVID-19 pandemic persisted several months after its outbreak and the end of the lockdown measures, respectively. Regarding well-being and stress, there is a slight trend toward improvement.

Improvements in benign prostatic hyperplasia-specific quality of life with dutasteride, the novel dual 5α-reductase inhibitor

2003 ◽  
Vol 92 (3) ◽  
pp. 262-266 ◽  
Author(s):  
M.P. O'Leary ◽  
C. Roehrborn ◽  
G. Andriole ◽  
C. Nickel ◽  
P. Boyle ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Benign Prostatic Hyperplasia ◽  
Reductase Inhibitor ◽  
Prostatic Hyperplasia ◽  
The Novel

scholarly journals Measuring the Quality of Life of Visually Impaired Children: First Stage Psychometric Evaluation of the Novel VQoL_CYP Instrument

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0146225 ◽  
Author(s):  
Valerija Tadić ◽  
Andrew Cooper ◽  
Phillippa Cumberland ◽  
Gillian Lewando-Hundt ◽  
Jugnoo S. Rahi
Keyword(s):  
Quality Of Life ◽  
Visually Impaired ◽  
Psychometric Evaluation ◽  
The Novel ◽  
Children First ◽  
Impaired Children ◽  
Visually Impaired Children
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