Assessing health status quality of life in ALS: Comparison of the SIP/ALS-19 with the ALS Functional Rating Scale and the Short Form-12 Health Survey

Background: Despite the excess risk of mortality in young women following acute myocardial infarction (AMI), little effort has been made to describe their long-term outcomes, particularly with respect to their health status (symptoms, function and quality of life). Accordingly, we assessed gender differences in 1-year health status outcomes after AMI. Methods: Data was used from the VIRGO study, an observational cohort of patients aged ≤55 years with AMI in the US and Spain (n=3,501, 67% women). Clinical data was abstracted from medical records and health status was obtained through patient interviews at the time of hospitalization and at 1-year later [Short Form 12 (SF-12) and the Seattle Angina Questionnaire (SAQ)]. Patient scores were categorized as “bad” if they had below average scores on the SF-12 components, had a score below 100 on the SAQ physical limitations (PL) or the SAQ angina frequency (AF), or had a score below 75 on the SAQ quality of life (QOL) at either baseline or 1-year. Patients were classified as having a “poor” outcome for a measure if they had a “bad” score at both baseline and 1-year or had a “bad” score at 1-year. Logistic regression models were used to assess factors associated with having a “poor” outcome for each scale. Results: The median age was 48 years (IQR: 44, 52). Women were more likely to present with diabetes (39% vs. 27%), obesity (51% vs. 45%), stroke (5% vs. 2%), heart failure (5% vs. 2%), lung disease (13% vs. 5%), and depression (48% vs. 24%, all P values <0.0001). Women were more likely to have “poor outcomes” compared with men (SF-12 PCS 46% vs. 30%; SF-12 MCS 47% vs. 30%; SAQ AF 32% vs. 25%; SAQ PL 29% vs. 20%; SAQ QOL 42% vs. 28%, all p-values <0.001). Female gender, prior AMI/percutaneous coronary intervention/coronary artery bypass grafting, and smoking within 30 days were independent predictors of having a “poor” outcome for all health status measures. Specifically, women had an increased odds of having a “poor” outcome on the SF-12 PCS (OR=2.05; 95% CI 1.69, 2.48), MCS (OR=1.98; 95% CI 1.65, 2.39), SAQ AF (OR=1.39; 95% CI 1.15, 1.67), SAQ PL (OR=1.62; 95% CI 1.32, 1.99) and the SAQ QOL scale (OR=1.84; 95% CI 1.53, 2.22), as compared with men. Conclusion: Compared with men, young women are more likely to have “poor” health status outcomes after AMI. This information is critically important in developing targets for gender-specific interventions to improve young women’s recovery post AMI.

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Health-Related Quality of Life of Older Adults in Costa Rica as Measured by the Short-Form-36 Health Survey

Gerontology and Geriatric Medicine ◽

10.1177/2333721418782812 ◽

2018 ◽

Vol 4 ◽

pp. 233372141878281 ◽

Cited By ~ 1

Author(s):

Esmeralda Valdivieso-Mora ◽

Mirjana Ivanisevic ◽

Leslie A. Shaw ◽

Mauricio Garnier-Villarreal ◽

Zachary D. Green ◽

...

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Costa Rica ◽

Health Survey ◽

Short Form ◽

Health Related Quality ◽

Short Form 36 ◽

Related Quality ◽

Health Related

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Quality of life in individuals with cervical dystonia before botulinum toxin injection in a Brazilian tertiary care hospital

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2011000700010 ◽

2011 ◽

Vol 69 (6) ◽

pp. 900-904 ◽

Cited By ~ 9

Author(s):

Mariana Ribeiro Queiroz ◽

Hsin Fen Chien ◽

Egberto Reis Barbosa

Keyword(s):

Quality Of Life ◽

Botulinum Toxin ◽

Cervical Dystonia ◽

Rating Scale ◽

Short Form ◽

Tertiary Care ◽

Residual Effect ◽

Care Hospital ◽

Sf 36

OBJECTIVE: The purpose of this study was to evaluate quality of life (QoL) in a Brazilian population of individuals with cervical dystonia (CD) without effect of botulinum toxin (BTx) or with only residual effect of BTx, and identify possible physical and social aspects that affect their QoL. METHOD: Sixty five out of sixty seven consecutive patients with CD were assessed with two instruments: Short-form Health Survey with 36 questions (SF-36) and Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). RESULTS: Severity of CD (TWSTRS) correlated moderately with two SF-36 subscale: role-physical (r= -0.42) and body pain (r= -0.43). Women also scored worse in two subscale of SF-36: vitality (p<0.05) and mental-health (p<0.005). CONCLUSION: Severity of CD and gender (female) were the main factors related to a worse QoL perception. These findings may help health professionals to predict which characteristics could lead to worse QoL, and therefore, better target their interventions to lessen the burden caused by CD.

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The association between physical activity and menopause-related quality of life

International Journal of Therapy and Rehabilitation ◽

10.12968/ijtr.2020.0118 ◽

2021 ◽

Vol 28 (5) ◽

pp. 1-11

Author(s):

Cyanna Joseph D'souza ◽

Santhakumar Haripriya ◽

Harish Sreekantan Krishna

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Rating Scale ◽

Psychological Symptoms ◽

Short Form ◽

Hormone Replacement ◽

Menopausal Symptoms ◽

Activity Levels ◽

Cross Sectional

Background/aims Menopause can cause drastic changes that trigger severe symptoms in women and, in turn, influence their quality of life. Many women no longer prefer hormone replacement therapy because of its potential adverse effects. Hence, it is crucial to establish alternate interventions to alleviate menopausal symptoms. The aim of this study was to estimate the relationship between quality of life and level of physical activity in menopausal women. Methods A total of 260 postmenopausal women were recruited in this cross-sectional study. The Menopause Rating Scale and International Physical Activity Questionnaire – Short Form were used to assess quality of life and physical activity respectively. Results Women with higher levels of physical activity had fewer total menopausal, somato-vegetative and psychological symptoms (P<0.001); no differences were found in vasomotor and urogenital symptoms. Conclusions Women with low physical activity levels presented with greater menopausal symptoms. Regular physical activity can be recommended to alleviate symptoms following menopause, thereby improving quality of life.

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Health-related quality of life in Marfan syndrome: a 10-year follow-up

Health and Quality of Life Outcomes ◽

10.1186/s12955-020-01633-4 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Thy Thy Vanem ◽

Svend Rand-Hendriksen ◽

Cathrine Brunborg ◽

Odd Ragnar Geiran ◽

Cecilie Røe

Keyword(s):

Quality Of Life ◽

Marfan Syndrome ◽

Health Survey ◽

Short Form ◽

Physical Domain ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Background Marfan syndrome, a rare hereditary connective tissue disorder caused by mutations in fibrillin-1, can affect many organ systems, especially the cardiovascular system. Previous research has paid less attention to health-related quality of life and prospective studies on this topic are needed. The aim of this study was to assess changes in health-related quality of life after 10 years in a Norwegian Marfan syndrome cohort. Methods Forty-seven Marfan syndrome patients ≥ 18 years were investigated for all organ manifestations in the 1996 Ghent nosology and completed the self-reported questionnaire, Short-Form-36 Health Survey, at baseline in 2003–2004 and at follow-up in 2014–2015. Paired sample t tests were performed to compare means and multiple regression analyses were performed with age, sex, new cardiovascular and new non-cardiovascular pathology as predictors. Results At 10-year follow-up: a significant decline was found in the physical domain. The mental domain was unchanged. Older age predicted a larger decline in physical health-related quality of life. None of the chosen Marfan-related variables predicted changes in any of the subscales of the Short-Form 36 Health Survey or in the physical or the mental domain. Conclusion Knowledge of decline in the physical domain, not related to organ affections, may be important in the follow-up of Marfan syndrome patients.

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Effect of probiotics on nasal and intestinal microbiota in people with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study

Trials ◽

10.1186/s13063-020-04759-4 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Yongcan Wu ◽

Caixia Pei ◽

Xiaomin Wang ◽

Mingjie Wang ◽

Demei Huang ◽

...

Keyword(s):

Quality Of Life ◽

Intestinal Microbiota ◽

Rating Scale ◽

Short Form ◽

Controlled Trial ◽

High Exposure ◽

Gastrointestinal Symptom Rating Scale ◽

Probiotic Treatment ◽

High Concentrations

Abstract Background Extended exposure to high concentrations of PM2.5 changes the human microbiota profile, which in turn may increase morbidity and mortality due to respiratory system damage. A balanced microecosystem is crucial to human health, and certain health-related problems may be addressed by effective microecosystem regulation. Recent studies have confirmed that probiotics may reduce the incidence of respiratory diseases. However, few studies have investigated probiotic treatment outcomes in subjects exposed to high concentrations of PM2.5. Methods This study is designed as a prospective, randomized, participants- and assessor-blinded, placebo-controlled trial. One hundred and twenty eligible volunteers recruited from October 2019 to July 2020 in downtown Chengdu, China, will be treated with either probiotics or placebo over 4 consecutive weeks. The primary outcome will be 16SrRNA sequencing assay data from nasal and intestinal secretions. Secondary outcomes will be pulmonary function, score on a gastrointestinal symptom rating scale, COOP/WONCA charts, and the Short-Form Health Survey 36 for quality of life. Results will be analyzed to assess differences in clinical efficacy between groups. Six-month follow-up examinations will evaluate the long-term value of probiotics on cardiovascular and respiratory disease end-point events. Discussion We will explore the characteristics of nasal and intestinal microbiota in a population with high exposure to PM2.5. Probiotics and placebo interventions will be tested for efficacy in microbial balance regulation, effects on lung and physical functions, and quality of life improvement. This study is expected to provide reliable evidence to support the widespread promotion of probiotics in clinical practice for the protection of individuals with high exposure to PM2.5. Trial registration Chinese Clinical Trial Registry ChiCTR1900025469. Registered on 27 August 2019.

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A comparison of quality of life in adolescents with epilepsy or asthma using the Short-Form Health Survey (SF-36)

Epilepsy Research ◽

10.1016/j.eplepsyres.2012.03.017 ◽

2012 ◽

Vol 101 (1-2) ◽

pp. 157-165 ◽

Cited By ~ 25

Author(s):

Ji Wang ◽

Yi Wang ◽

Li Bo Wang ◽

Hui Xu ◽

Xiao-lei Zhang

Keyword(s):

Quality Of Life ◽

Health Survey ◽

Short Form ◽

Short Form Health Survey ◽

Form Health ◽

Sf 36 ◽

Short Form Health

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Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

Journal of Clinical Oncology ◽

10.1200/jco.18.00896 ◽

2019 ◽

Vol 37 (2) ◽

pp. 135-143 ◽

Cited By ~ 8

Author(s):

Jingru Jiang ◽

Yi Li ◽

Qingyu Shen ◽

Xiaoming Rong ◽

Xiaolong Huang ◽

...

Keyword(s):

Quality Of Life ◽

Adverse Event ◽

Neuropathic Pain ◽

Rating Scale ◽

Short Form ◽

Controlled Trial ◽

Numeric Rating Scale ◽

Mood States ◽

Numeric Rating

Purpose Neuropathic pain is an unavoidable treatment-related adverse event among patients with head and neck cancer who are undergoing radiotherapy. We aimed to test the efficacy and safety of pregabalin versus placebo in the treatment of radiotherapy-related neuropathic pain. Patients and Methods This randomized, double-blind, placebo-controlled trial was conducted in four centers in China. Eligible patients with a mean pain intensity score of 4 or more on an 11-point numeric rating scale were randomly assigned to receive either active treatment with a flexible dose of pregabalin or placebo for 16 weeks. The primary efficacy outcome was pain reduction measured on the numeric rating scale. Result There were 128 patients who received treatment as randomly assigned. Pain intensity reduction was 2.44 in the pregabalin arm and 1.58 in the placebo arm at week 16, yielding an adjusted mean difference of 0.87 (95% CI, 0.30 to 1.44; P = .003). In the pregabalin arm, 38 patients (59.4%) achieved at least 30% pain relief versus 21 (32.8%) in the placebo arm ( P = .006). Nineteen patients (29.7%) in the pregabalin group and five (7.8%) in the placebo group achieved 50% or greater pain relief ( P = .003). Total scores on the Profile of Mood States-Short Form, pain severity and functional interference of Brief Pain Inventory-Short Form, as well as the physiology and psychology domain of the WHO Quality of Life-BREF all were reduced significantly at week 16 in patients who received pregabalin compared with those who received placebo. There was no significant difference ( P = .29) in the incidence of experiencing at least one adverse event in the pregabalin arm (n = 35; 54.7%) versus the placebo arm (n = 29; 45.3%). Conclusion Patients treated with pregabalin with radiotherapy-related neuropathic pain had greater pain alleviation, better mood states, and higher quality of life compared with patients in the placebo group, with a good tolerability.

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