Changes of intestinal microbiota in early life

2018 ◽  
Vol 33 (6) ◽  
pp. 1036-1043 ◽  
Author(s):  
Monica Ficara ◽  
Elisa Pietrella ◽  
Caterina Spada ◽  
Elisa Della Casa Muttini ◽  
Laura Lucaccioni ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Early Life

scholarly journals Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Z. H. Miao ◽  
W. X. Zhou ◽  
R. Y. Cheng ◽  
H. J. Liang ◽  
F. L. Jiang ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Early Life ◽  
Fasting Blood Glucose ◽  
Fecal Microbiota ◽  
Long Term Effects ◽  
High Fat ◽  
Host Animal ◽  
Intestinal Microbes ◽  
Lipid Metabolism Disorders

Abstract Background Accumulating evidence have shown that the intestinal microbiota plays an important role in prevention of host obesity and metabolism disorders. Recent studies also demonstrate that early life is the key time for the colonization of intestinal microbes in host. However, there are few studies focusing on possible association between intestinal microbiota in the early life and metabolism in adulthood. Therefore the present study was conducted to examine whether the short term antibiotic and/or probiotic exposure in early life could affect intestinal microbes and their possible long term effects on host metabolism. Results A high-fat diet resulted in glucose and lipid metabolism disorders with higher levels of visceral fat rate, insulin-resistance indices, and leptin. Exposure to ceftriaxone in early life aggravated the negative influences of a high-fat diet on mouse physiology. Orally fed TMC3115 protected mice, especially those who had received treatment throughout the whole study, from damage due to a high-fat diet, such as increases in levels of fasting blood glucose and serum levels of insulin, leptin, and IR indices. Exposure to ceftriaxone during the first 2 weeks of life was linked to dysbiosis of the fecal microbiota with a significant decrease in the species richness and diversity. However, the influence of orally fed ceftriaxone on the fecal microbiota was limited to 12 weeks after the termination of treatment. Of note, at week 12 there were still some differences in the composition of intestinal microbiota between mice provided with high fat diet and antibiotic exposure and those only fed a high fat diet. Conclusions These results indicated that exposure to antibiotics, such as ceftriaxone, in early life may aggravate the negative influences of a high-fat diet on the physiology of the host animal. These results also suggest that the crosstalk between the host and their intestinal microbiota in early life may be more important than that in adulthood, even though the same intestinal microbes are present in adulthood.

scholarly journals Ratio of Klebsiella/Bifidobacterium in early life correlates with later development of paediatric allergy

2017 ◽  
Vol 8 (5) ◽  
pp. 681-695 ◽  
Author(s):  
J.S.Y. Low ◽  
S.-E. Soh ◽  
Y.K. Lee ◽  
K.Y.C. Kwek ◽  
J.D. Holbrook ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Allergic Disease ◽  
Early Life ◽  
16S Rrna Gene Sequencing ◽  
Early Infancy ◽  
Rrna Gene ◽  
Microbial Composition ◽  
Healthy Infants ◽  
Increased Risk ◽  
Paediatric Allergy

Several studies have reported that intestinal microbial colonisation patterns differ between non-allergic and allergic infants. However, the microbial signature underlying the pathogenesis of allergies remains unclear. We aim to gain insight into the development of the intestinal microbiota of healthy infants and infants who develop allergy in early life, and identify potential microbiota biomarkers of later allergic disease. Using a case-control design in a Chinese sub-cohort of a Singaporean birth cohort (GUSTO), we utilised 16S rRNA gene sequencing to assess intestinal microbial composition and diversity of 21 allergic and 18 healthy infants at 3 weeks, 3 months and 6 months of age, and correlated the microbiota with allergy at ages 18 and 36 months. Pronounced differences in intestinal microbiota composition between allergic and healthy infants were observed at 3 months of age. The intestine of healthy infants was colonised with higher abundance of commensal Bifidobacterium. Conversely, Klebsiella, an opportunistic pathogen, was significantly enriched in the allergic infants. Interestingly, infants with a high Klebsiella/Bifidobacterium (K/B) ratio (above the population median K/B ratio) at age 3 months had an odds ratio of developing allergy by 3 years of age of 9.00 (95% confidence interval 1.46-55.50) compared to those with low K/B ratio. This study demonstrated a relationship between the ratio of genera Klebsiella and Bifidobacterium during early infancy and development of paediatric allergy in childhood. Our study postulates that an elevated K/B ratio in early infancy could be a potential indicator of an increased risk of allergy development. This line of research might enable future intervention strategies in early life to prevent or treat allergy. Our study provides new insights into microbial signatures associated with childhood allergy, in particular, suggests that an elevated K/B ratio could be a potential early-life microbiota biomarker of allergic disease.

scholarly journals Multi-population cohort meta-analysis of human intestinal microbiota in early life reveals the existence of infant community state types (ICSTs)

2020 ◽  
Vol 18 ◽  
pp. 2480-2493
Author(s):  
Leonardo Mancabelli ◽  
Chiara Tarracchini ◽  
Christian Milani ◽  
Gabriele Andrea Lugli ◽  
Federico Fontana ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Early Life ◽  
Meta Analysis ◽  
Population Cohort ◽  
Human Intestinal Microbiota

Regulation of wheat germ polysaccharides in the immune response of mice from newborn to adulthood associated with intestinal microbiota

2020 ◽  
Vol 11 (11) ◽  
pp. 9662-9674
Author(s):  
Liyuan Yun ◽  
Wen Li ◽  
Yanan Liu ◽  
Tao Wu ◽  
Min Zhang
Keyword(s):  
Immune Response ◽  
Intestinal Microbiota ◽  
Early Life ◽  
Wheat Germ

The aim of this study was to determine the effects of wheat germ polysaccharides (WGPs), which are indigestible carbohydrate fibers, on mice in early life, and the changes leading to long-lasting consequences.

scholarly journals Intestinal Microbiota in Early Life and Its Implications on Childhood Health

2019 ◽  
Vol 17 (1) ◽  
pp. 13-25 ◽  
Author(s):  
Lu Zhuang ◽  
Haihua Chen ◽  
Sheng Zhang ◽  
Jiahui Zhuang ◽  
Qiuping Li ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Early Life ◽  
Childhood Health

Structural characteristics and succession of intestinal microbiota for Paralichthys olivaceus during the early life stage

2018 ◽  
Vol 50 (2) ◽  
pp. 529-540
Author(s):  
Yan Jiang ◽  
Zengxin Liu ◽  
Xuezhou Liu ◽  
Yongjiang Xu ◽  
Bao Shi ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Early Life ◽  
Structural Characteristics ◽  
Paralichthys Olivaceus ◽  
Life Stage ◽  
Early Life Stage

scholarly journals Impact of early-life feeding on local intestinal microbiota and digestive system development in piglets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
R. Choudhury ◽  
A. Middelkoop ◽  
J. G. de Souza ◽  
L. A. van Veen ◽  
W. J. J. Gerrits ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Early Life ◽  
Intestinal Tract ◽  
System Development ◽  
Jejunal Mucosa ◽  
Intestinal Development ◽  
Microbiota Composition ◽  
Early Feeding ◽  
Fermentation Products ◽  
The Impact

AbstractEarly-life gut microbial colonisation is known to influence host physiology and development, shaping its phenotype. The developing gastro-intestinal tract of neonatal piglets provides a “window of opportunity” for programming their intestinal microbiota composition and corresponding intestinal development. Here, we investigated the impact of early feeding on jejunum and colon microbiota composition, and intestinal maturation in suckling piglets. From two days of age, early-fed (EF; n = 6 litters) piglets had access to solid feed containing a mixture of fibres till weaning (day29) in addition to sow’s milk, whereas the control (CON; n = 6 litters) piglets exclusively fed on sow’s milk. Early feeding elicited a significant impact on the colon microbiota, whereas no such effect was seen in the jejunal and ileal microbiota. Quantified eating behavioural scores could significantly explain the variation in microbiota composition of EF piglets and support their classification into good, moderate, and bad eaters. Members of the Lachnospiraceae family, and the genera Eubacterium, Prevotella, and Ruminococcus were quantitatively associated with eating scores. EF piglets were found to have a decreased pH in caecum and colon, which coincided with increased short-chain fatty acid (SCFA) concentrations. Moreover, they also had increased weights and lengths of several intestinal tract segments, as well as a decreased villus-crypt ratio in jejunal mucosa and an increased abundance of proliferative cells in colon mucosa. The approaches in this study indicate that early feeding of a mixed-fibre (pre-weaning) diet changes the microbiota composition, pH, and fermentation products in the distal gut of piglets, while it also alters both macroscopic and microscopic intestinal measurements. These results exemplify the potential of early feeding to modulate intestinal development in young piglets.

scholarly journals Intestinal microbiota during early life – impact on health and disease

2014 ◽  
Vol 73 (4) ◽  
pp. 457-469 ◽  
Author(s):  
Lotta Nylund ◽  
Reetta Satokari ◽  
Seppo Salminen ◽  
Willem M. de Vos
Keyword(s):  
Intestinal Microbiota ◽  
Early Life ◽  
Later Life ◽  
Related Factors ◽  
Life Impact ◽  
Health And Disease ◽  
And Function ◽  
The Impact

In the first years after birth, the intestinal microbiota develops rapidly both in diversity and complexity while being relatively stable in healthy adults. Different life-style-related factors as well as medical practices have an influence on the early-life intestinal colonisation. We address the impact of some of these factors on the consecutive microbiota development and later health. An overview is presented of the microbial colonisation steps and the role of the host in that process. Moreover, new early biomarkers are discussed with examples that include the association of microbiota and atopic diseases, the correlation of colic and early development and the impact of the use of antibiotics in early life. Our understanding of the development and function of the intestinal microbiota is constantly improving but the long-term influence of early-life microbiota on later life health deserves careful clinical studies.

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