Differences of Legal Regulations Concerning Involuntary Psychiatric Hospitalization in Twelve European Countries: Implications for Clinical Practice

Genetic testing in children raises many important ethical, legal, and social issues. One of the main concerns is the ethically inappropriate genetic testing of minors. Various European countries established professional guidelines which reflect the different countries perspectives regarding the main ethical issues involved. In this paper, we analyze the Italian and the British guidelines by highlighting differences and similarities. We discuss presymptomatic, predictive, and carrier testing because we consider them to be the more ethically problematic types of genetic testing in minors. In our opinion, national guidelines should take into account the different needs in clinical practice. At the same time, in the case of genetic testing the national and supranational protection of minors could be strengthened by approving guidelines based on a common framework of principles and values. We suggest that the Oviedo Convention could represent an example of such a common framework or, at least, it could lead to articulate it.

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Biomarker testing and mutation prevalence in metastatic colorectal cancer patients in five European countries using a large oncology database

Future Oncology ◽

10.2217/fon-2020-0975 ◽

2021 ◽

Author(s):

George Kafatos ◽

Victoria Banks ◽

Peter Burdon ◽

David Neasham ◽

Caroline Anger ◽

...

Keyword(s):

Colorectal Cancer ◽

Clinical Practice ◽

Metastatic Colorectal Cancer ◽

Cancer Patients ◽

Braf Mutation ◽

European Countries ◽

High Prevalence ◽

Biomarker Testing ◽

Colorectal Cancer Patients ◽

Over Time

Background: The literature on biomarker testing for metastatic colorectal cancer (mCRC) in Europe is scarce. This study aimed to estimate the percentage of mCRC patients from five European countries tested for biomarkers over time. Materials & methods: An oncology database was retrospectively analyzed; evaluated biomarkers were RAS, BRAF and microsatellite instability (MSI). The patients were drug treated during 2018 and tested for relevant biomarkers in 2013–2018. Results: RAS testing was conducted in >90% of mCRC patients from 2014 onwards. BRAF testing increased from 31% of mCRC patients in 2013 to 67% in 2018. MSI testing increased from 10 to 41%. There was no notable trend over time for RAS and BRAF mutation or MSI-high prevalence. Conclusion: Biomarker testing among patients diagnosed with mCRC was increased over time. This study demonstrates the quick uptake of biomarker testing in clinical practice. These findings are significant as biomarker-based drugs are becoming more common.

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Obstacles in conducting clinical trials in the Saudi Arabia

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20174864 ◽

2017 ◽

Vol 4 (4) ◽

pp. 166

Author(s):

Salem D. Al Suwaidan ◽

Aseel S. Alsuwaidan

Keyword(s):

Clinical Trials ◽

Saudi Arabia ◽

Clinical Practice ◽

Clinical Research ◽

Strategic Plan ◽

Good Clinical Practice ◽

European Countries ◽

Regulatory Authorities ◽

Research Institution

Background: Conducting clinical research in accordance with the standards of regulatory authorities and within the guidelines of the good clinical practice (GCP) is a matter of concern. It has been noticed that some increment in the conduction of clinical trials outside USA and European countries in the last two decades. The main objective of this study is to identify the magnitude of some obstacles that affect the conduction of clinical trials in accordance with the GCP.Methods: Developing questionnaire in accordance with the criteria of the GCP would make assessment on how to buildup infrastructure including policy and procedures of the research institution. Recommendation of the study is to perform this questionnaire every other year to assess the progress and development of the research institution.Conclusions: To identify good clinical researchers, what sort of obstacle(s) regarding conducting clinical trials, and from these obstacles how to resolve it and build up infrastructure for the research institution and also to establish the strategic plan for the research institution.

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Adoption of the ADA/EASD guidelines in 10 Eastern and Southern European countries: physician survey and good clinical practice recommendations from an International Expert Panel

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2020.108535 ◽

2020 ◽

pp. 108535

Author(s):

South Expert Panel ◽

Maciej Banach ◽

Dan Gaita ◽

Martin Haluzik ◽

Andrej Janez ◽

...

Keyword(s):

Clinical Practice ◽

Expert Panel ◽

Good Clinical Practice ◽

European Countries ◽

Physician Survey ◽

International Expert ◽

Practice Recommendations ◽

Southern European Countries

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Infection Control and Hospital Hygiene in Belgium

Infection Control and Hospital Epidemiology ◽

10.1086/645994 ◽

1989 ◽

Vol 10 (4) ◽

pp. 170-174

Author(s):

Gerald Reybrouck ◽

Raf Mertens

Keyword(s):

Infection Control ◽

Nosocomial Infections ◽

European Countries ◽

Legal Regulations ◽

Hospital Hygiene ◽

Council Of Europe ◽

Member States ◽

Control Policies ◽

Western European ◽

Set Up

In 1972 the Council of Europe, in which most of the Western European countries are represented, adopted a resolution aimed at the improvement of hospital hygiene and the promotion of the prevention of nosocomial infections. The member states were invited to take the required measures, but each country was free to implement the resolution according to its own needs and particularities. In Belgium, the first legal regulations were issued in 1974—every hospital was obliged to set up a committee for hospital hygiene.Although similar regulations were issued in most other member states. the actual infection control policies adopted can vary. This article highlights some of the particularities for Belgium.

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