Pleural mesothelioma and lung cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes

ENGLISH SUMMARYLangseth H. Cancer risk in Norwegian pulp and paper workers. Nor J Epidemiol 2001; 11 (2): 187-192.Results from a historical prospective cohort study on Norwegian pulp and paper workers showed a significantincrease in risk of lung cancer, pleural mesothelioma, colon cancer and malignant melanomas amongmen, compared to the Norwegian population. The risk of lung cancer was highest among sulphite millworkers. The risk of pleural mesothelioma was highest among maintenance workers with asbestos exposure.Most of the increased risk in lung cancer can be explained by a combination of smoking habits andasbestos use, although an effect of other work-related exposures (sulfur and chloride compounds, wooddust) cannot be excluded. Among the female part of the cohort we found a significant excess in risk ofovarian cancer. The risk was highest among those younger than 55 years, and mostly among those workingin paper departments. Relatively little is known about the causes of ovarian cancer, but it is howeverknown that 5-7% can be explained by hereditary factors. Furthermore, fertility pattern plays a role.Asbestos and talc, which both have been used in the pulp and paper industry, are occupational and environmentalagents, discussed as possible carcinogens for ovarian cancer.

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118 The role of the lung cancer nurse specialist in providing legal advice to patients diagnosed with malignant pleural mesothelioma

Lung Cancer ◽

10.1016/s0169-5002(12)70119-8 ◽

2012 ◽

Vol 75 ◽

pp. S39

Author(s):

S. Bolton

Keyword(s):

Lung Cancer ◽

Malignant Pleural Mesothelioma ◽

Nurse Specialist ◽

Pleural Mesothelioma ◽

Legal Advice

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Screening for Malignant Pleural Mesothelioma and Lung Cancer in Individuals with a History of Asbestos Exposure

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e31819f2e0e ◽

2009 ◽

Vol 4 (5) ◽

pp. 620-628 ◽

Cited By ~ 46

Author(s):

Heidi C. Roberts ◽

Demetris A. Patsios ◽

Narinder S. Paul ◽

Marc dePerrot ◽

Warren Teel ◽

...

Keyword(s):

Lung Cancer ◽

Malignant Pleural Mesothelioma ◽

Asbestos Exposure ◽

Pleural Mesothelioma ◽

History Of

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Role of Selected Genetic Variants in Lung Cancer Risk in African Americans

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e318283da29 ◽

2013 ◽

Vol 8 (4) ◽

pp. 391-397 ◽

Cited By ~ 20

Author(s):

Margaret R. Spitz ◽

Christopher I. Amos ◽

Susan Land ◽

Xifeng Wu ◽

Qiong Dong ◽

...

Keyword(s):

Lung Cancer ◽

African Americans ◽

Cancer Risk ◽

Genetic Variants ◽

Lung Cancer Risk

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The role of iron in pulmonary pathology

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2015.337 ◽

2019 ◽

Vol 10 ◽

Author(s):

Heena Khiroya ◽

Alice M. Turner

Keyword(s):

Lung Cancer ◽

Pulmonary Disease ◽

Respiratory Disease ◽

Cigarette Smoke ◽

Iron Metabolism ◽

Iron Homeostasis ◽

Association Studies ◽

Regulatory Protein ◽

Chronic Obstructive

Respiratory disease accounts for a large proportion of emergency admissions to hospital and diseaseassociated mortality. Genetic association studies demonstrate a link between iron metabolism and pulmonary disease phenotypes. IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which has a key role in iron homeostasis. This review addresses pathways involved in iron metabolism, particularly focusing on the role of IREB2 . In addition to this, environmental factors also influence phenotypic variation in respiratory disease, for example inhaled iron from cigarette smoke is deposited in the lung and causes tissue damage by altering iron homeostasis. The effects of cigarette smoke are detailed in this article, particularly in relation to lung conditions that favour the upper lobes, such as emphysema and lung cancer. Clinical applications of iron homeostasis are also discussed in this review, especially looking at the pathophysiology of chronic obstructive pulmonary disease, lung cancer, pulmonary infections and acute respiratory distress syndrome. Promising new treatments involving iron are also covered.

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Comparison between Plasma and Serum Osteopontin Levels: Usefulness in Diagnosis of Epithelial Malignant Pleural Mesothelioma

The International Journal of Biological Markers ◽

10.1177/172460081002500307 ◽

2010 ◽

Vol 25 (3) ◽

pp. 164-170 ◽

Cited By ~ 24

Author(s):

Alfonso Cristaudo ◽

Rudy Foddis ◽

Alessandra Bonotti ◽

Silvia Simonini ◽

Agnese Vivaldi ◽

...

Keyword(s):

Malignant Pleural Mesothelioma ◽

Healthy Subjects ◽

Asbestos Exposure ◽

Control Group ◽

Pleural Mesothelioma ◽

Serum Samples ◽

Temperature Plasma ◽

Commercial Laboratory ◽

Different Temperatures

Background A potential role of serum osteopontin (OPN) and serum mesothelin-related peptide (SMRP) in the diagnosis of malignant pleural mesothelioma (MPM) has been recently reported. Although the most important data regarding the role of OPN in MPMs derive from the marker's measurement in serum samples, most commercial laboratory kits for OPN assay are suitable only for measuring plasma levels, as indicated by the manufacturers. Our study aimed to evaluate the influence of preanalytic variables on serum and plasma OPN, to compare serum and plasma OPN in the same population, and to assess whether OPN levels can aid in the diagnostic distinction of patients with MPM versus benign respiratory disease (BRD) and healthy subjects exposed to asbestos. Methods The influence of preanalytic variables such as the length of storage at different temperatures and the number of thawings of samples on serum and plasma OPN measurements were evaluated. We measured OPN in 239 plasma samples from 207 asbestos-exposed subjects including 94 healthy controls and 113 subjects with BRD, and 32 patients with epithelial MPM, employing a commercially available ELISA. Serum OPN was measured in 196 of the same 239 samples from 80 healthy subjects, 92 BRD patients and 24 MPM patients. Results We found that both serum and plasma OPN levels were influenced by storage at –80°C and by the number of thawings, while serum OPN was influenced also by storage at room temperature. Plasma and serum OPN levels were significantly higher (p<0.0001) in patients with epithelial MPM than in the healthy control group and the BRD group. The application of a ROC curve for plasma OPN resulted in an AUC value of 0.780 with a best cutoff of 878.65 ng/mL, with a sensitivity of 68.8% and a specificity of 84.5%. The AUC for sOPN was 0.725 with a best cutoff of 16.06 ng/mL, with a sensitivity of 62.5% and a specificity of 87.3%. Within the control group no significant correlation was observed between age, duration of asbestos exposure, pack-years in current smokers, lung function or imaging parameters and plasma or serum OPN. Conclusions These data suggest that plasm OPN and serum OPN are not influenced by confounding factors such as age, smoking habits and asbestos exposure. Plasma and serum OPN may be useful markers in the diagnosis of epithelial MPM in addition to traditional radiological exams. However, in our opinion plasma OPN is preferable to serum OPN because it is more stable and measurements of OPN in serum are less reliable.

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