scholarly journals TDP43 ribonucleoprotein granules: physiologic function to pathologic aggregates

RNA Biology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Giulia Ada Corbet ◽  
Joshua R. Wheeler ◽  
Roy Parker ◽  
Kaitlin Weskamp
Keyword(s):  
Physiologic Function

scholarly journals The SH2-Containing Inositol Polyphosphate 5-Phosphatase, Ship, Is Expressed During Hematopoiesis and Spermatogenesis

Blood ◽  
1998 ◽  
Vol 91 (8) ◽  
pp. 2753-2759 ◽  
Author(s):  
Qiurong Liu ◽  
Fouad Shalaby ◽  
Jamie Jones ◽  
Denis Bouchard ◽  
Daniel J. Dumont
Keyword(s):  
Primitive Streak ◽  
Inositol Polyphosphate ◽  
Mouse Development ◽  
Developmentally Regulated ◽  
Adult Mice ◽  
Expression Studies ◽  
Cell Culture Systems ◽  
Physiologic Function ◽  
T Cell Maturation

Ship is a recently identified SH2-containing inositol polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems. To understand the physiologic function of Ship in vivo, we performed expression studies of Ship during mouse development. Results of this study demonstrate the expression of ship to be in late primitive-streak stage embryos (7.5 days postcoitus [dpc]), when hematopoiesis is thought to begin, and the expression is restricted to the hematopoietic lineage in mouse embryo. In adult mice, Ship expression continues to be in the majority of cells from hematopoietic origin, including granulocytes, monocytes, and lymphocytes, and is also found in the spermatids of the testis. Furthermore, the level of Ship expression is developmentally regulated during T-cell maturation. These results suggest a possible role for Ship in the differentiation and maintenance of the hematopoietic lineages and in spermatogenesis.

The Endocrine System: Pituitary Gland

2017 ◽  
Author(s):  
Omer Doron ◽  
Jose E Cohen ◽  
Iddo Paldor
Keyword(s):  
Pituitary Gland ◽  
Human Body ◽  
Sella Turcica ◽  
Endocrine System ◽  
Portal System ◽  
Balance Growth ◽  
Sexual Drive ◽  
Pituitary Dysfunction ◽  
Physiologic Function ◽  
And Function

The pituitary gland is the main point where the neural and endocrine systems function in continuity, maintaining homeostasis of many functional elements of the human body. Located inside the sella turcica, it is separated from the rest of the central nervous system (CNS); however, it plays a crucial part in the regulation of the fundamental endocrine profile, inhibiting or promoting CNS signaling to the rest of the human body. Made up of two distinct tissue subtypes, this gland is fed by a complex vascular network, which enables communication beyond the blood-brain barrier. Lying in close proximity to both important neural and vascular structure, changes in gland size and function result in significant clinical impact. The pituitary gland controls many processes, among which are thermoregulation; metabolism and metabolic rate; glucose, solute, and water balance; growth and development; blood pressure; and sexual drive, pregnancy, childbearing, birth, and breast-feeding. The devastating effects of pituitary dysfunction underscore the importance of the pituitary gland in maintenance of the various functions that underlie normal everyday human activity. This review covers the basic aspects of pituitary gland development, anatomy, and physiologic function. This review contains 3 figures, and 38 references, Key words: adenohypophysis, neurohypophysis, pituitary-hypothalamic axis, pituitary portal system, sella turcica

scholarly journals The Effect of Green Space on the Physiologic Function of the Adult: A Systematic Review

2021 ◽  
Author(s):  
Brenna Franco
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Cohort Studies ◽  
Protective Factor ◽  
Green Space ◽  
Inclusion Criteria ◽  
Disease Awareness ◽  
Obesity And Diabetes ◽  
Physiologic Function ◽  
Cardiovascular Illness

Environmental greenness is often associated with improved psychological outcomes, but the use of green space as a protective factor for maintaining physiologic health is understudied. However, growing evidence exists on the benefit of greenness on physiologic health. The purpose of this systematic review was to evaluate the effect of green space on the physiologic function of the adult. Cohort studies were searched for that had all elements of inclusion criteria. Six final studies were included in this systematic review utilizing PRISMA guidelines and CASP tool for cohort studies. Data from the studies was collected and a cross study analysis was conducted to compare all studies and assess for themes in study outcomes. Results of this review demonstrate that green space has a protective effect on physiologic health. Areas with higher levels of greenness are associated with lower prevalence of central obesity, diabetes mellitus, and self-reported rates of cardiovascular disease and stroke as well as decreased rates of mortality from cancers, and kidney and respiratory diseases. Implications of this study include the importance in understanding risk factors for development of disease. Awareness of a patient’s environment that includes natural spaces should be identified as a potential risk factor for the development of cardiovascular illness, obesity, and diabetes mellitus.

scholarly journals Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 89
Author(s):  
Dang Wang ◽  
Ruixue Wang ◽  
Kui Li
Keyword(s):  
Antiviral Treatment ◽  
Interferon Α ◽  
Type I ◽  
Null Cell ◽  
Double Stranded Rna ◽  
Antiviral Responses ◽  
Bioactivity Assay ◽  
Physiologic Function ◽  
Vesicular Stomatitis ◽  
The Impact

The physiologic function of tripartite motif protein 56 (TRIM56), a ubiquitously expressed E3 ligase classified within the large TRIM protein family, remains elusive. Gene knockdown studies have suggested TRIM56 as a positive regulator of the type I interferon (IFN-I) antiviral response elicited via the Toll-like receptor 3 (TLR3) and cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathways, which detect and respond to danger signals—extracellular double-stranded (ds) RNA and cytosolic dsDNA, respectively. However, to what extent these pathways depend on TRIM56 in human cells is unclear. In addition, it is debatable whether TRIM56 plays a part in controlling the expression of IFN-stimulated genes (ISGs) resulting from IFN-I based antiviral treatment. In this study, we created HeLa-derived TRIM56 null cell lines by gene editing and used these cell models to comprehensively examine the impact of endogenous TRIM56 on innate antiviral responses. Our results showed that TRIM56 knockout severely undermined the upregulation of ISGs by extracellular dsRNA and that loss of TRIM56 weakened the response to cytosolic dsDNA. ISG induction and ISGylation following IFN-α stimulation, however, were not compromised by TRIM56 deletion. Using a vesicular stomatitis virus-based antiviral bioactivity assay, we demonstrated that IFN-α could efficiently establish an antiviral state in TRIM56 null cells, providing direct evidence that TRIM56 is not required for the general antiviral action of IFN-I. Altogether, these data ascertain the contributions of TRIM56 to TLR3- and cGAS–STING-dependent antiviral pathways in HeLa cells and add to our understanding of the roles this protein plays in innate immunity.

scholarly journals Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes.

1996 ◽  
Vol 184 (3) ◽  
pp. 811-819 ◽  
Author(s):  
L Biancone ◽  
M A Bowen ◽  
A Lim ◽  
A Aruffo ◽  
G Andres ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Divalent Cations ◽  
Membranous Glomerulonephritis ◽  
Murine Splenocytes ◽  
Cell Clones ◽  
Physiologic Function ◽  
Antigen Presenting

CD5 is a 67-kD glycoprotein that is expressed on most T lymphocytes and on a subset of mature B cells. Although its physiologic function is unknown, several lines of evidence suggest that CD5 may play a role in the regulation of T cell activation and in T cell-antigen presenting cell interactions. Using a CD5-immunoglobulin fusion protein (CD5Rg, for receptorglobulin) we have uncovered a new CD5 ligand (CD5L) expressed on the surface of activated splenocytes. Stimulation of murine splenocytes with anti-CD3 and anti-CD28 antibodies induce transient expression of CD5L on B lymphocytes that lasts for approximately 72 h. Binding of CD5Rg to activated splenocytes is trypsin resistant and independent of divalent cations. However, it is pronase sensitive and dependent on N-linked glycosylation of CD5, since treatment of CD5Rg with PNGaseF on N-glycanase completely abrogates its ability to bind activated splenocytes. It addition to splenocytes, CD5L is expressed on activated murine T cell clones. Immunoprecipitation, antibody, and recombinant protein blocking studies indicate that CD5L is distinct from CD72, which has been proposed to be a CD5 ligand. To determine whether CD5-CD5L interaction might play a role in vivo, we tested the effect of CD5Rg in a murine model of antibody-mediated membranous glomerulonephritis. Injection of CD5Rg was found to abrogate development of the disease. Taken together, our results help identify a novel ligand of CD5 and propose a role for CD5 in the regulation of immune responses.

scholarly journals Scaling Physiologic Function from Cell to Tissue in Asthma, Cancer, and Development

2018 ◽  
Vol 15 (Supplement_1) ◽  
pp. S35-S37
Author(s):  
Yasha Sharma ◽  
Lior Atia ◽  
Christalyn Sims Rhodes ◽  
Stephen J. DeCamp ◽  
Jennifer Mitchel ◽  
...  
Keyword(s):  
Physiologic Function

The Endocrine System: Pituitary Gland

2017 ◽  
Author(s):  
Omer Doron ◽  
Jose E Cohen ◽  
Iddo Paldor
Keyword(s):  
Pituitary Gland ◽  
Human Body ◽  
Sella Turcica ◽  
Endocrine System ◽  
Portal System ◽  
Balance Growth ◽  
Sexual Drive ◽  
Pituitary Dysfunction ◽  
Physiologic Function ◽  
And Function

The pituitary gland is the main point where the neural and endocrine systems function in continuity, maintaining homeostasis of many functional elements of the human body. Located inside the sella turcica, it is separated from the rest of the central nervous system (CNS); however, it plays a crucial part in the regulation of the fundamental endocrine profile, inhibiting or promoting CNS signaling to the rest of the human body. Made up of two distinct tissue subtypes, this gland is fed by a complex vascular network, which enables communication beyond the blood-brain barrier. Lying in close proximity to both important neural and vascular structure, changes in gland size and function result in significant clinical impact. The pituitary gland controls many processes, among which are thermoregulation; metabolism and metabolic rate; glucose, solute, and water balance; growth and development; blood pressure; and sexual drive, pregnancy, childbearing, birth, and breast-feeding. The devastating effects of pituitary dysfunction underscore the importance of the pituitary gland in maintenance of the various functions that underlie normal everyday human activity. This review covers the basic aspects of pituitary gland development, anatomy, and physiologic function. This review contains 3 figures, and 38 references, Key words: adenohypophysis, neurohypophysis, pituitary-hypothalamic axis, pituitary portal system, sella turcica

SERIOUS UNTOWARD REACTIONS TO THERAPY WITH CORTISONE AND ADRENOCORTICOTROPIN IN PEDIATRIC PRACTICE (PART I)

PEDIATRICS ◽  
1957 ◽  
Vol 19 (1) ◽  
pp. 95-118
Author(s):  
Robert A. Good ◽  
Robert L. Vernier ◽  
Richard T. Smith
Keyword(s):  
Experimental Approach ◽  
Clinical Medicine ◽  
Medical Center ◽  
Medical Science ◽  
Pediatric Practice ◽  
Beneficial Effects ◽  
Physiologic Function ◽  
The Common ◽  
Pharmacologic Agents ◽  
Toxic Reactions

THE INTRODUCTION of cortisone and adrenocorticotropin (ACTH) into clinical medicine by Hench et al. has profoundly influenced both medical practice and medical science. Voluminous literature which has collected during the 5 years since their introduction establishes securely the effectiveness of these hormonal agents in diseases previously refractory to medical management. In the laboratory these drugs have also opened whole fields to investigation with a new experimental approach. Data already available suggest that ultimate discovery of the basis of the action of cortisone and ACTH will carry broad inmplications concerning physiologic function and mechanisms of disease. A natural consequence of the introduction of such potent and versatile weapons into clinical medicine is that they should be widely used. In almost every human disease, ranging from the common cold to disseminated malignancy, the steroid hormones and ACTH have been tried. For example, it can be factually stated that few truly ill patients reach the diagnostic medical center without having had at least small amounts of cortisone or ACTH, and it is the extremely unusual patient who reaches the necropsy table without the "benefit" of ACTH, cortisone or one of its analogues. As these drugs have been studied, it has become ever more apparent that they are extraordinarily potent pharmacologic agents which effect or control mammalian physiology in multitudinous areas, perhaps in several different ways. More gradually it has been realized that their effects are not all beneficial. Because of enthusiasm engendered by the availability of potent new pharmacologic agents, reporting from most clinics to date has emphasized the dramatic beneficial effects and tended to minimize the untoward side effects, toxic reactions and potential hazards of hormone therapy. It is the purpose of this report to review some of the hazards of treatment with cortisone and ACTH in pediatric practice.

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