Recent advances in intraocular and novel drug delivery systems for the treatment of diabetic retinopathy

Bacteriophages (phages) are viruses that infect bacterial hosts, and since their discovery over a century ago they have been primarily exploited to control bacterial populations and to serve as tools in molecular biology. In this commentary, we highlight recent diverse advances in the field of phage research, going beyond bacterial control using whole phage, to areas including biocontrol using phage-derived enzybiotics, diagnostics, drug discovery, novel drug delivery systems and bionanotechnology.

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Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00303 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1014

Author(s):

Xiao-Hong HAO ◽

Cui-Miao ZHANG ◽

Xiao-Long LIU ◽

Xing-Jie LIANG ◽

Guang JIA ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Recent Advances ◽

Nano Drug Delivery

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Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

Current Pharmaceutical Design ◽

10.2174/1381612826666201021130146 ◽

2020 ◽

Vol 26 ◽

Author(s):

Ritu Mishra ◽

Swati Gupta

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Autoimmune Disease ◽

Drug Delivery Systems ◽

Clinical Manifestations ◽

Adaptive Immune Response ◽

Delivery Systems ◽

Current Therapy ◽

Genetic And Environmental Factors ◽

Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

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Provesicles as Novel Drug Delivery Systems

Current Pharmaceutical Biotechnology ◽

10.2174/1389201016666150206101443 ◽

2015 ◽

Vol 16 (4) ◽

pp. 344-364 ◽

Cited By ~ 6

Author(s):

Zerrin Bayindir ◽

Nilufer Yuksel

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Novel Drug

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Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review

Current Drug Targets ◽

10.2174/1389450117666160613103705 ◽

2017 ◽

Vol 18 (11) ◽

Cited By ~ 4

Author(s):

Rohit R. Bhosale ◽

H. V. Gangadharappa ◽

Umme Hani ◽

Riyaz Ali M. Osmani ◽

Rudra Vaghela ◽

...

Keyword(s):

Prostate Cancer ◽

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Novel Drug

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Novel Drug Delivery Systems for Releasing Growth Factors to the CNS: Focus on Alzheimer’s and Parkinson’s Diseases

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557514666140622205058 ◽

2014 ◽

Vol 14 (7) ◽

pp. 557-566

Author(s):

E. Herran ◽

M. Igartua ◽

J.L. Pedraz ◽

R.M. Hernandez

Keyword(s):

Drug Delivery ◽

Growth Factors ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Parkinson’S Diseases ◽

Novel Drug

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Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190904145355 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1001-1016

Author(s):

Sandra Ramírez-Rave ◽

María Josefa Bernad-Bernad ◽

Jesús Gracia-Mora ◽

Anatoly K. Yatsimirsky

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery Systems ◽

Mesoporous Silica Nanoparticles ◽

High Surface ◽

Delivery Systems ◽

Surface Reactivity ◽

External Stimulus ◽

Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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Role of novel drug delivery systems in coronavirus disease-2019 (covid-19): time to act now

Current Drug Delivery ◽

10.2174/1567201817666200916090710 ◽

2020 ◽

Vol 17 ◽

Author(s):

Neeraj Mittal ◽

Varun Garg ◽

Sanjay Kumar Bhadada ◽

O. P. Katare

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

World Health ◽

Ongoing Research ◽

Standard Drug ◽

Corona Virus ◽

Novel Drug

: The corona virus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel corona virus SARS-CoV2, previously named as 2019-nCoV. COVID-19 has spread across the globe and declared as pandemic by World health organization (WHO) on 11th March, 2020. Currently, there is no standard drug or vaccine available for the treatment, so repurposing of existing drugs is the only solution. Novel drug delivery systems (NDDS) will be boon for the repurposing of drugs. The role of various NDDS in repurposing of existing drugs for treatment of various viral diseases and their relevance in COVID-19 has discussed in this paper. It focuses on the currently ongoing research in the implementation of NDDS in COVID-19. Moreover it describes the role of NDDS in vaccine development for COVID-19. This paper also emphasizes how NDDS will help to develop the improved delivery systems (dosage forms) of existing therapeutic agents and also explore the new insights to find out the void spaces for a potential targeted delivery. So in these tough times, NDDS and nanotechnology can be a safeguard to humanity.

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