Occupational therapists (OTs) have a unique and valued role in the health and functional recovery of individuals with multiple sclerosis (MS). To maximize the benefit of occupational therapy by both health care professionals who refer patients and the patients who use the services, an understanding of the scope of services that OTs offer is essential. This article describes the breadth of the OT evaluation and intervention specific to the treatment of individuals who have MS. As an overriding goal, the OT assists clients in processing the implications of physical, cognitive, and emotional changes and creatively developing strategies to cope with and, when appropriate, minimize the effects of these changes. The occupational therapy process is described, beginning with evaluation and providing guidelines and resources for appropriate client-centered goal setting. The OT and client then discuss intervention that ensures optimal functional outcome and includes symptomatic management, according to the specific functional difficulties and implications and the particular symptoms of each patient. Through discussion, the OT helps each client achieve health and well-being with remedial and compensatory techniques that enable participation in meaningful activities and roles in the home, work, and community. OT services are essential to the appropriate and optimal delivery of comprehensive care and support to individuals with MS.