ABSTRACT Background: Complementary feeding practice is needed to be optimized to maximize children’s potential for growth and development. However, there are still many obstacles in provide complementary feeding practice. This study aimed to examine the determinants of complementary feeding practice. Subjects and Method: A cross sectional study was conducted in Gunungkidul, Yogyakarta, Indonesia, from October to November 2019. A sample of 200 mothers who had infants aged 6-24 months was selected by probability sampling. The dependent variable was complementary feeding practice. The independent variables were birthweight, child nutritional status, maternal knowledge toward complementary feeding, maternal education, and family income. The data were collected by infant weight scale, infantometer, and questionnaire. The data were analyzed by a multiple logistic regression run on Stata 13. Results: Complementary feeding practice increased with birthweight ≥2500 g (b= 2.67; 95% CI=0.59 to.89; p= 0.008), child nutritional status (WHZ) -2.0 to 2.0 SD (b= 2.72; 95% CI=o.75 to 4.61; p= 0.006), high maternal knowledge toward complementary feeding (b= 2.27; 95% CI= 0.27 to 3.79; p= 0.023), maternal education ≥Senior high school (b= 2.19; 95% CI= 0.23 to 4.25; p= 0.028), and family income ≥Rp 1,571,000 (b= 2.42; 95% CI= 0.39 to 3.77; p= 0.015). Conclusion: Complementary feeding practice increases with birthweight ≥2500 g, good child nutritional status, high maternal knowledge toward complementary feeding, high maternal education, and high family income. Keywords: complementary feeding, path analysis Correspondence: Renidya Asyura Muttabi’ Deya Fa’ni. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Mobile: +62 815 3934 0421. DOI: https://doi.org/10.26911/the7thicph.03.103