scholarly journals Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila

2021 ◽  
pp. 1-10
Author(s):  
Sang Hyuk Lee ◽  
Eun Young Kim
Keyword(s):  
Sleep Fragmentation ◽  
Short Term ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose ◽  
Term Maintenance

scholarly journals Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats

2002 ◽  
Vol 87 (4) ◽  
pp. 337-342 ◽  
Author(s):  
Jérôme Busserolles ◽  
Edmond Rock ◽  
Elyett Gueux ◽  
Andrzej Mazur ◽  
Pascal Grolier ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Tbars Level ◽  
Short Term ◽  
Antioxidant Defence ◽  
Sod Activity ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

The underlying mechanisms for the detrimental consequences of a high-fructose diet in animal models are not clear. However, the possibility exists that fructose feeding facilitates oxidative damage. Thus, the aim of the present study was to assess, in weaning rats, the effect of a high-sucrose diet v. starch diet for 2 weeks on oxidative stress variables. Plasma lipid levels were measured and lipid peroxidation was evaluated by urine and plasma thiobarbituric acid-reactive substances (TBARS). The susceptibilities of several tissues to peroxidation were determined in tissue homogenates after in vitro lipid peroxidation. Antioxidant defence variables were evaluated by measuring plasma and heart vitamin E levels, and heart superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities. Higher plasma triacylglycerol (P<0·01) and TBARS (P<0·01) levels were found in rats fed the sucrose diet as compared with the starch-fed group, whereas plasma α-tocopherol levels were significantly decreased in the sucrose-fed group compared with the starch-fed group (P<0·01). Higher urine TBARS (P<0·01) were found in the sucrose-fed group compared with the starch-fed group, suggesting increased production of these substances from lipid peroxidation in vivo. Higher susceptibility to peroxidation in heart, thymus and pancreas was also found in the sucrose-fed group v. the starch-fed group. No statistical differences were observed for liver TBARS level between the two groups. Heart SOD activity was significantly decreased (P<0·001) in the sucrose-fed group compared with the starch-fed group, whereas heart vitamin E level and GPX activity were not different between the groups. However, the in vitro generation of superoxide radical in heart homogenate, measured by electron spin resonance detection and spin trapping, was not increased in the sucrose-fed group compared with starch-fed rats. Altogether, the results indicate that a short-term consumption of a high-sucrose diet negatively affects the balance of free radical production and antioxidant defence in rats, leading to increased lipid susceptibility to peroxidation.

A short term high-fat high-sucrose diet in mice impairs optic nerve recovery after injury and this is not reversed by exercise

2017 ◽  
Vol 162 ◽  
pp. 104-109 ◽  
Author(s):  
Vicki Chrysostomou ◽  
Peter van Wijngaarden ◽  
Gregory R. Steinberg ◽  
Jonathan G. Crowston
Keyword(s):  
Optic Nerve ◽  
High Fat ◽  
Short Term ◽  
Sucrose Diet ◽  
Nerve Recovery ◽  
High Sucrose Diet ◽  
High Sucrose

Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1723-P
Author(s):  
IRENA MARKOVÁ ◽  
MARTINA HÜTTL ◽  
HANA MALINSKA ◽  
ONDREJ SEDA ◽  
LUDMILA KAZDOVA
Keyword(s):  
Metabolic Syndrome ◽  
Sucrose Diet ◽  
Transcriptomic Signature ◽  
High Sucrose Diet ◽  
High Sucrose

Motor learning impairment in rats under a high sucrose diet

2021 ◽  
Vol 234 ◽  
pp. 113384
Author(s):  
Nayely Flores-Fuentes ◽  
Carolina Hernandez-Cruz ◽  
Karina Bermeo ◽  
Antonio Barajas-Martinez ◽  
Valeria Nayely Hernandez-Serratos ◽  
...  
Keyword(s):  
Motor Learning ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Learning Impairment ◽  
High Sucrose

scholarly journals Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sang Hyuk Lee ◽  
Eunjoo Cho ◽  
Sung-Eun Yoon ◽  
Youngjoon Kim ◽  
Eun Young Kim
Keyword(s):  
Locomotor Behavior ◽  
Sensory Inputs ◽  
Sucrose Diet ◽  
High Nutrient ◽  
Intracellular Ca ◽  
High Sucrose Diet ◽  
Locomotor Activities ◽  
Locomotor Behaviors ◽  
High Sucrose ◽  
Over Time

AbstractMetabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca2+ levels in DN1ps suggesting an inhibitory connection. The contacts between DN1ps and DTk neurons increased gradually over time in flies fed a high-sucrose diet, consistent with the locomotor behavior. DN1ps have been implicated in integrating environmental sensory inputs (e.g., light and temperature) to control daily locomotor behavior. This study revealed that DN1ps also coordinated nutrient information through DTk signaling to shape daily locomotor behavior.

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