scholarly journals miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury

Bioengineered ◽  
2021 ◽  
Author(s):  
Yunguang Wang ◽  
Fangfang Feng ◽  
Wenfang He ◽  
Lifang Sun ◽  
Qiang He ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Type I Diabetes ◽  
Type I ◽  
Mitochondrial Injury

scholarly journals Modulation of TGF-β/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model

2010 ◽  
Vol 9 (1) ◽  
pp. 55 ◽  
Author(s):  
Peter E Westerweel ◽  
Cindy TJ van Velthoven ◽  
Tri Q Nguyen ◽  
Krista den Ouden ◽  
Dominique PV de Kleijn ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Mouse Model ◽  
Progenitor Cells ◽  
Type I Diabetes ◽  
Type I ◽  
Muscle Progenitor Cells ◽  
Diabetes Mouse

A Search for Association between the Polymorphic Markers of PON1 and PON2 Genes and Diabetic Nephropathy in Patients with Type I Diabetes Mellitus

2005 ◽  
Vol 41 (6) ◽  
pp. 688-692
Author(s):  
O. E. Voron’ko ◽  
N. Yu. Yakunina ◽  
M. V. Shestakova ◽  
E. V. Zotova ◽  
L. A. Chugunova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Polymorphic Markers

scholarly journals The C825T polymorphism in the human G-protein β3 subunit gene is not associated with diabetic nephropathy in Type I diabetes mellitus

Diabetologia ◽  
1998 ◽  
Vol 41 (11) ◽  
pp. 1304-1308 ◽  
Author(s):  
D. G. Fogarty ◽  
M. J. Zychma ◽  
L. J. Scott ◽  
J. H. Warram ◽  
A. S. Krolewski
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
G Protein ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Subunit Gene ◽  
C825t Polymorphism

scholarly journals Conjunctival blood flow after endovascular laser therapy in patients with diabetic nephropathy

1997 ◽  
Vol 43 (6) ◽  
pp. 17-20
Author(s):  
Yu. I. Grinshtein ◽  
S. V. Ivliev ◽  
N. B. Osetrova ◽  
S. S. Ilyenkov
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Renal Insufficiency ◽  
Laser Therapy ◽  
Chronic Renal Insufficiency ◽  
Vascular Tone ◽  
Type I Diabetes ◽  
Type I ◽  
Microcirculatory Disorders ◽  
Reliable Increase

The conjunctival bloodflow was examined in patients with diabetic nephropathy with different status of renal function and changes in the microcirculatory bed assessed after endovascular laser therapy. Twenty-five donors and twenty-one patients with medium-severe and grave type I diabetes complicated by diabetic nephropathy were followed up. Microcirculatory disorders in the eyeball conjunctiva progressed as renal function deteriorated, which was evident from a reliable increase of the total conjunctival index in parallel with the progress of chronic- renal insufficiency. A course of endovascular laser therapy reliably improved the microcirculation: the arterio-venular coefficient increased and the total conjunctival index decreased in patients with latent and conservatively curable stages of chronic renal insufficiency due to normalization of vascular tone, boosting of the bloodflow, and decrease of red cell sludging.

scholarly journals Clinical and laboratory characteristics of the renoretinal syndrome in diabetics

1996 ◽  
Vol 42 (3) ◽  
pp. 3-6
Author(s):  
M. I. Balabolkin ◽  
G. G. Mamayeva ◽  
V. Yu. Evgrafov ◽  
L. I. Lyudina ◽  
N. A. Bishele
Keyword(s):  
Diabetic Nephropathy ◽  
Type I Diabetes ◽  
Type I ◽  
Ophthalmological Examination ◽  
Type Ii ◽  
Pathological Changes ◽  
Clinical Methods ◽  
Microcirculatory Disorders ◽  
Lipid Spectrum ◽  
Fundus Oculi

A total of 107 diabetics were examined using general clinical methods, assessment of microalbuminemia, Rehbergs test for renal function, coagulogram, thromboelastogram, lipid spectrum of the serum, and ophthalmological examination. The stages of diabetic nephropathy and retinopathy and degree of the major pathological changes in the retina were found to be in direct correlation. Initial diabetic retinopathy was found to develop earlier than nephropathy in the majority of patients, and preproliferative and proliferative retinopathy was appreciably more incident in the presence of diabetic nephropathy. Changes in the fundus oculi were more expressed in patients with type I diabetes and nephropathy than in those with type II condition. At the same time, the development of diabetic nephropathy was associated with deterioration of the fundus oculi parameters only in diabetics with type II condition, whereas in those with type I disease it influenced only the number of microaneurysms. The progress of diabetic nephropathy with increase of proteinuria may be caused by such risk factors as microcirculatory disorders and changes in the lipid spectrum of the blood serum.

scholarly journals Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in Type I diabetes mellitus

Diabetologia ◽  
2000 ◽  
Vol 43 (12) ◽  
pp. 1540-1543 ◽  
Author(s):  
S. Araki ◽  
Y. Makita ◽  
L. Canani ◽  
D. Ng ◽  
J. H. Warram ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Paraoxonase 1 ◽  
Type I
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