Release Kinetics of Acyclovir from a Suspension of Acyclovir Incorporated in a Cubic Phase Delivery System

2001 ◽  
Vol 27 (10) ◽  
pp. 1073-1081 ◽  
Author(s):  
Lise Sylvest Nielsen ◽  
Lise Sylvest Helledi ◽  
Lene Schubert
1999 ◽  
Vol 25 (1) ◽  
pp. 15-20 ◽  
Author(s):  
R. Michael Kelly ◽  
Jeffrey D. Meyer ◽  
James E. Matsuura ◽  
Eli Shefter ◽  
Michael J. Hart ◽  
...  

2015 ◽  
Vol 132 (26) ◽  
pp. n/a-n/a ◽  
Author(s):  
Hui Yun Zhou ◽  
Pei Pei Cao ◽  
Jun Bo Li ◽  
Fa Liang Zhang ◽  
Pei Pei Ding

2014 ◽  
Vol 22 (2) ◽  
pp. 171-176
Author(s):  
Kan WANG ◽  
Zifang WANG ◽  
Ming GAO ◽  
Yaohua HUANG ◽  
Xiaofei HAN ◽  
...  

2021 ◽  
Vol 2 ◽  
pp. 100077
Author(s):  
Sudipta Das ◽  
Arnab Samanta ◽  
Shouvik Mondal ◽  
Debatri Roy ◽  
Amit Kumar Nayak

2021 ◽  
Vol 55 (6) ◽  
pp. 3676-3685
Author(s):  
Yu Wang ◽  
Fang Wang ◽  
Leilei Xiang ◽  
Chenggang Gu ◽  
Marc Redmile-Gordon ◽  
...  

Author(s):  
Lorenzo Lisuzzo ◽  
Giuseppe Cavallaro ◽  
Stefana Milioto ◽  
Giuseppe Lazzara

AbstractIn this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and $$\zeta$$ ζ -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.


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