scholarly journals Human Pathogenic Virus–Associated Pseudolymphomas and Lymphomas with Primary Cutaneous Manifestation in Humans and Animals

1998 ◽  
Vol 27 (5) ◽  
pp. 1299-1308 ◽  
Author(s):  
M. Wagner ◽  
V. A. Rose ◽  
R. Linder ◽  
H. J. Schulze ◽  
G. R. F. Krueger
Keyword(s):  
Cutaneous Manifestation ◽  
Pathogenic Virus ◽  
Human Pathogenic Virus

scholarly journals Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses

2020 ◽  
Vol 21 (23) ◽  
pp. 9289
Author(s):  
Dörthe Masemann ◽  
Stephan Ludwig ◽  
Yvonne Boergeling
Keyword(s):  
Transgenic Mice ◽  
Medical Research ◽  
Disease Pathogenesis ◽  
Pathogenic Virus ◽  
Precision Therapy ◽  
Pathogenic Viruses ◽  
Virus Research ◽  
And Control ◽  
Human Pathogenic Virus ◽  
Human Specific

Medical research is changing into direction of precision therapy, thus, sophisticated preclinical models are urgently needed. In human pathogenic virus research, the major technical hurdle is not only to translate discoveries from animals to treatments of humans, but also to overcome the problem of interspecies differences with regard to productive infections and comparable disease development. Transgenic mice provide a basis for research of disease pathogenesis after infection with human-specific viruses. Today, humanized mice can be found at the very heart of this forefront of medical research allowing for recapitulation of disease pathogenesis and drug mechanisms in humans. This review discusses progress in the development and use of transgenic mice for the study of virus-induced human diseases towards identification of new drug innovations to treat and control human pathogenic infectious diseases.

Coliphage Presence in Various Types of Potable Water in Thailand

1989 ◽  
Vol 24 (4) ◽  
pp. 583-588 ◽  
Author(s):  
Komol Sivaborvorn ◽  
B.J. Dutka
Keyword(s):  
Drinking Water ◽  
Potable Water ◽  
Tap Water ◽  
Total Coliform ◽  
Well Water ◽  
Paper Strip ◽  
Deep Well ◽  
Pathogenic Virus ◽  
Strip Test ◽  
Human Pathogenic Virus

Abstract Three types of drinking water used in Thailand, tap water, rain water and deep well water (200 m) were tested for bacteriological and coliphage content. 13.5% of the samples contained only coliphage and 13% contained both coliphage and total coliforms. The incidence of coliphage in these potable water supplies reflect the probability of human pathogenic virus also surviving in these waters. The H2S paper-strip test was found to be an equally sensitive indicator of coliform presence compared to MF and MPN total coliform procedures.

scholarly journals First detection of bat-borne Issyk-Kul virus in Europe

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Annika Brinkmann ◽  
Claudia Kohl ◽  
Aleksandar Radonić ◽  
Piotr Wojtek Dabrowski ◽  
Kristin Mühldorfer ◽  
...  
Keyword(s):  
Central Asia ◽  
Zoonotic Viruses ◽  
Pathogenic Virus ◽  
The Family ◽  
Potential Reservoir ◽  
Reservoir Hosts ◽  
First Time ◽  
Human Pathogenic Virus ◽  
Vespertilionid Bats

AbstractBats have been gaining attention as potential reservoir hosts of numerous viruses pathogenic to animals and man. Issyk-Kul virus, a member of the family Nairoviridae, was first isolated in the 1970s from vespertilionid bats in Central Asia. Issyk-Kul virus has been described as human-pathogenic virus, causing febrile outbreaks in humans with headaches, myalgia and nausea. Here we describe the detection of a novel strain of Issyk-Kul virus from Eptesicus nilssonii in Germany. This finding indicates for the first time the prevalence of these zoonotic viruses in Europe.

scholarly journals Parvovirus B19 Achievements and Challenges

ISRN Virology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-33 ◽  
Author(s):  
Giorgio Gallinella
Keyword(s):  
Immune System ◽  
Parvovirus B19 ◽  
Clinical Manifestations ◽  
Adaptive Immune System ◽  
Cell Physiology ◽  
Adaptive Immune ◽  
Pathogenic Virus ◽  
Human Pathogenic Virus ◽  
Replicative Cycle

Parvovirus B19 is a widespread human pathogenic virus, member of the Erythrovirus genus in the Parvoviridae family. Infection can be associated with an ample range of pathologies and clinical manifestations, whose characteristics and outcomes depend on the interplay between the pathogenetic potential of the virus, its adaptation to different cellular environments, and the physiological and immune status of the infected individuals. The scope of this review is the advances in knowledge on the biological characteristics of the virus and of virus-host relationships; in particular, the interactions of the virus with different cellular environments in terms of tropism and ability to achieve a productive replicative cycle, or, on the contrary, to establish persistence; the consequences of infection in terms of interference with the cell physiology; the process of recognition of the virus by the innate or adaptive immune system, hence the role of the immune system in controlling the infection or in the development of clinical manifestations. Linked to these issues is the continuous effort to develop better diagnostic algorithms and methods and the need for development of prophylactic and therapeutic options for B19V infections.

The Plummer-Vinson syndrome. A cutaneous manifestation of internal disease

1972 ◽  
Vol 105 (5) ◽  
pp. 720-721 ◽  
Author(s):  
D. Schetman
Keyword(s):  
Cutaneous Manifestation ◽  
Plummer Vinson Syndrome

The Changing Spectrum of the Cutaneous Manifestation of HIV Disease

1999 ◽  
Vol 135 (4) ◽  
pp. 471-471 ◽  
Author(s):  
R. Colebunders
Keyword(s):  
Cutaneous Manifestation ◽  
Hiv Disease

Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

2020 ◽  
Vol 20 ◽  
Author(s):  
Christine Ibrahim ◽  
Hanna Semaan ◽  
Marwan El-Sabban ◽  
Fadia Najjar ◽  
Aline Hamade
Keyword(s):  
Stem Cell ◽  
Drug Repositioning ◽  
World Health ◽  
Unknown Etiology ◽  
Cell Based Therapy ◽  
Pathogenic Virus ◽  
Lung Injuries ◽  
Healthcare Crisis ◽  
Health Organization ◽  
Potential Use

: Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

Therapeutic Exploitation of Viral Interference

2020 ◽  
Vol 20 (4) ◽  
pp. 423-432 ◽  
Author(s):  
Imre Kovesdi ◽  
Tibor Bakacs
Keyword(s):  
Broad Spectrum ◽  
Viral Infections ◽  
Viral Vector ◽  
Antiviral Treatment ◽  
Type I ◽  
Virus Infections ◽  
Emerging Viruses ◽  
Viral Interference ◽  
Pathogenic Virus ◽  
Hepatitis C Rna

: Viral interference, originally, referred to a state of temporary immunity, is a state whereby infection with a virus limits replication or production of a second infecting virus. However, replication of a second virus could also be dominant over the first virus. In fact, dominance can alternate between the two viruses. Expression of type I interferon genes is many times upregulated in infected epithelial cells. Since the interferon system can control most, if not all, virus infections in the absence of adaptive immunity, it was proposed that viral induction of a nonspecific localized temporary state of immunity may provide a strategy to control viral infections. Clinical observations also support such a theory, which gave credence to the development of superinfection therapy (SIT). SIT is an innovative therapeutic approach where a non-pathogenic virus is used to infect patients harboring a pathogenic virus. : For the functional cure of persistent viral infections and for the development of broad- spectrum antivirals against emerging viruses a paradigm shift was recently proposed. Instead of the virus, the therapy should be directed at the host. Such a host-directed-therapy (HDT) strategy could be the activation of endogenous innate immune response via toll-like receptors (TLRs). Superinfection therapy is such a host-directed-therapy, which has been validated in patients infected with two completely different viruses, the hepatitis B (DNA), and hepatitis C (RNA) viruses. SIT exerts post-infection interference via the constant presence of an attenuated non-pathogenic avian double- stranded (ds) RNA viral vector which boosts the endogenous innate (IFN) response. SIT could, therefore, be developed into a biological platform for a new “one drug, multiple bugs” broad-spectrum antiviral treatment approach.

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