Phytosome is a complex between natural active ingredient and a phospholipid.
Further, phytosomes been applied to many popular herbal extracts or active molecules for
augmenting oral dissolution. Therefore, in present investigation, orally administered Baicalein,
atype of flavanoids, is poorly absorbed, and shows suboptimal dissolution. The phytosomes
encapsulating baicalein (1:1 Mm) were prepared by reverse phase evaporation method followed
by lyophilization. Transmission electron microscopy (TEM) analysis revealed that phytosomes
were almost spherical in shape with particle size below 100 nm. The Powder ex-ray diffraction
(PXRD) and differential scanning calorimetry (DSC) demonstrated that Baicalein loaded
phytosomes were amorphous in nature. Amorphization of therapeutic moiety leads to
improvement in dissolution. In conclusion, epigallocatechin loaded phytosomes exhibited
promising results and warrant further in vitro andin vivo investigations under a set of stringent
parameters for transforming in to a clinically viable products.