Effects of laser acupoint irradiation on blood glucose and glycosylated hemoglobin in type 2 diabetes mellitus

Laser Physics ◽  
2016 ◽  
Vol 26 (6) ◽  
pp. 065604
Author(s):  
Liu Hui-Hui ◽  
Xiong Guo-Xin ◽  
Zhang Li-Ping
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin

scholarly journals A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Follow-Up

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Huiqin Li ◽  
Xiaohua Xu ◽  
Jie Wang ◽  
Xiaocen Kong ◽  
Maoyuan Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Oxidation Stress ◽  
Once Daily ◽  
Glucose Fluctuation ◽  
Significant Difference

Objective. To evaluate the effects of once-weekly dulaglutide injection and once-daily glimepiride on glucose fluctuation in patients with type 2 diabetes mellitus (T2DM) using the Continuous Glucose Monitoring System (CGMS). Methods. A total of 23 patients with T2DM were randomly assigned into two groups for 26 weeks: the dulaglutide group (n=13) and the glimepiride group (n=10). 72-hour CGMS was applied to all patients: before and after the treatment. General clinical data were collected and measured, such as fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), tumor necrosis factor-α (TNF-α), 8-iso-prostaglandin F2α (8-iso-PGF2α), and interleukin-6 (IL-6). Results. HbA1c of the dulaglutide group was reduced from 8.38±0.93% to 6.68±0.73% after the treatment (P<0.05); similarly, it was reduced from 7.91±0.98% to 6.67±0.74% (P<0.05) in the glimepiride group. The levels of serum 8-iso-PGF2α, TNF-α, and IL-6 all decreased significantly in both groups after treatment, and there was no significant difference found between the two groups (P>0.05). The Mean Blood Glucose (MBG) of the two groups declined significantly after therapy (P<0.05). However, the Standard Deviation of Blood Glucose (SDBG) decreased significantly only in the dulaglutide group (from 2.57±0.74 mmol/L to 1.98±0.74 mmol/L, P<0.05). There were no significant changes of Mean Amplitude of Glycemic Excursion (MAGE) and Absolute Means of Daily Difference (MODD) after treatment in both groups. Furthermore, no statistically significant difference was found between the two groups in MBG, SDBG, MAGE, and MODD (P>0.05). The percentage time (PT) (>10 mmol/L and 3.9-10 mmol/L) of the two groups was significantly changed after the treatment (P<0.05). However, this was not seen in the PT<3.9 mmol/L after the treatment (P>0.05). Conclusion. Once-weekly dulaglutide injection has the same effectiveness as daily glimepiride on lowering blood glucose and decreasing oxidation stress and inflammation and is more effective in controlling glucose fluctuation as compared with glimepiride. This trial is registered with ClinicalTrials.gov NCT01644500.

scholarly journals Fructus MumeFormula in the Treatment of Type 2 Diabetes Mellitus: A Randomized Controlled Pilot Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xiang Tu ◽  
ChunGuang Xie ◽  
Fei Wang ◽  
Qiu Chen ◽  
ZhiHuang Zuo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Pilot Study ◽  
Controlled Trial ◽  
Glycosylated Hemoglobin ◽  
Pilot Trial ◽  
Randomized Controlled

Background. “Fructus Mumeor Dark Plum” (pilule form) has been used for many years in Traditional Chinese Medicine (TCM) and may be a valid treatment for type 2 diabetes mellitus (T2DM).Aim. One aspect toward efficacy validation is the evaluation of the blood glucose-lowering effect ofFructus Mume(FM) with T2DM patients in a randomized controlled trial (RCT).Methods. This pilot study uses a RCT procedure to assess efficacy ofFMand Metformin. The trial was for 12 weeks, with 80 T2DM subjects. Both groups were standardized in their diet and exercise routine. Comparisons of several variables were analyzed.Results. No significant differences were found between groups in the fasting and postprandial glucose levels although both had significant decreases. The values of glycosylated hemoglobin were significantly reduced in both groups. For patients whose body mass index (BMI) was <23, neitherFMnor Metformin had an effect on BMI; for those with a BMI between 23 and 25 or the BMI was >25, bothFMand Metformin significantly reduce the BMI.Conclusions. In this pilot study, it was demonstrated thatFructus Mumeformula may reduce the levels of blood glucose in patients with type 2 diabetes.

scholarly journals Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Ganesh N. Dakhale ◽  
Harshal V. Chaudhari ◽  
Meena Shrivastava
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Ascorbic Acid ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Vitamin C ◽  
Glycosylated Hemoglobin ◽  
Double Blind ◽  
Type 2 Dm

No study has ever examined the effect of vitamin C with metformin on fasting (FBS) and postmeal blood glucose (PMBG) as well as glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). The goal was to examine the effect of oral vitamin C with metformin on FBS, PMBG, HbA1c, and plasma ascorbic acid level (PAA) with type 2 DM. Seventy patients with type 2 DM participated in a prospective, double-blind, placebo-controlled, 12-week study. The patients with type 2 DM were divided randomly into placebo and vitamin C group of 35 each. Both groups received the treatment for twelve weeks. Decreased PAA levels were found in patients with type 2 diabetes mellitus. This level was reversed significantly after treatment with vitamin C along with metformin compared to placebo with metformin. FBS, PMBG, and HbA1c levels showed significant improvement after 12 weeks of treatment with vitamin C. In conclusion, oral supplementation of vitamin C with metformin reverses ascorbic acid levels, reduces FBS, PMBG, and improves HbA1c. Hence, both the drugs in combination may be used in the treatment of type 2 DM to maintain good glycemic control.

scholarly journals A CROSS SECTIONAL STUDY OF TYPE 2 DIABETES MELLITUS COMPARING DIFFERENT FACTORS BETWEEN LEAN BODY WEIGHT, NON OBESE AND OBESE PATIENTS IN WESTERN UTTAR PRADESH

2020 ◽  
Vol 3 (01) ◽  
pp. 404-407
Author(s):  
Manish Shrivastav ◽  
Nihit Kharkwal ◽  
Alankar Tiwari ◽  
Keshav Kumar Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lean Body Mass ◽  
Body Mass ◽  
Glycosylated Hemoglobin ◽  
Uttar Pradesh ◽  
Lean Body Weight

Introduction- Incidence and prevalence of diabetes mellitus has been increased quite rapidly from last decade. It was thought previously that obesity is one of the major predisposing risk factor and complications of diabetes would be more common and fatal in obese persons with diabetes, but it has been shown in more recent studies that some of the factors and peculiarities are much more common in patients with lean body mass. Material and methods- This study was done in a tertiary care centre of western Uttar Pradesh over 240 cases of type 2 diabetes mellitus that were divided into three categories in equal proportion considering their body mass index (lean , non obese and obese ). Some of the factors like urine microscopy, fasting and post prandial glucose level, glycosylated hemoglobin, lipid profile and kidney functions were studied to find out the difference in level of above mentioned factors in these groups. Results- Fasting blood glucose, post prandial blood glucose, glycosylated hemoglobin level, and triglyceride level came to be signinifiacntly higher in lean body mass group as compared to other two groups. As far as renal status is concerned there was no significant variation in different groups of diabetes mellitus. Conclusion- Present study showed that lean body weight type of type 2 diabetes mellitus are definitely different subset of population of type 2 diabetes mellitus with clinical characteristics different from other subtype i.e. non obese and obese in this region of country.   Introduction- Incidence and prevalence of diabetes mellitus has been increased quite rapidly from last decade. It was thought previously that obesity is one of the major predisposing risk factor and complications of diabetes would be more common and fatal in obese persons with diabetes, but it has been shown in more recent studies that some of the factors and peculiarities are much more common in patients with lean body mass. Material and methods- This study was done in a tertiary care centre of western Uttar Pradesh over 240 cases of type 2 diabetes mellitus that were divided into three categories in equal proportion considering their body mass index (lean , non obese and obese ). Some of the factors like urine microscopy, fasting and post prandial glucose level, glycosylated hemoglobin, lipid profile and kidney functions were studied to find out the difference in level of above mentioned factors in these groups. Results- Fasting blood glucose, post prandial blood glucose, glycosylated hemoglobin level, and triglyceride level came to be signinifiacntly higher in lean body mass group as compared to other two groups. As far as renal status is concerned there was no significant variation in different groups of diabetes mellitus. Conclusion- Present study showed that lean body weight type of type 2 diabetes mellitus are definitely different subset of population of type 2 diabetes mellitus with clinical characteristics different from other subtype i.e. non obese and obese in this region of country.   Introduction- Incidence and prevalence of diabetes mellitus has been increased quite rapidly from last decade. It was thought previously that obesity is one of the major predisposing risk factor and complications of diabetes would be more common and fatal in obese persons with diabetes, but it has been shown in more recent studies that some of the factors and peculiarities are much more common in patients with lean body mass. Material and methods- This study was done in a tertiary care centre of western Uttar Pradesh over 240 cases of type 2 diabetes mellitus that were divided into three categories in equal proportion considering their body mass index (lean , non obese and obese ). Some of the factors like urine microscopy, fasting and post prandial glucose level, glycosylated hemoglobin, lipid profile and kidney functions were studied to find out the difference in level of above mentioned factors in these groups. Results- Fasting blood glucose, post prandial blood glucose, glycosylated hemoglobin level, and triglyceride level came to be signinifiacntly higher in lean body mass group as compared to other two groups. As far as renal status is concerned there was no significant variation in different groups of diabetes mellitus. Conclusion- Present study showed that lean body weight type of type 2 diabetes mellitus are definitely different subset of population of type 2 diabetes mellitus with clinical characteristics different from other subtype i.e. non obese and obese in this region of country.  

High HBA1C Level Is Associated With Low Heamoglobin Level

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Mafooza Rashid ◽  
B. K. Gupta, Vinay Bharat ◽  
Abhishek Gupta ◽  
Zubair Rashid
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Good Control ◽  
Diabetic Control ◽  
Medical College ◽  
High Hba1c ◽  
Normal Controls

Background: The aim of the study was to compare the hemoglobin levels among normal controls (patients) and patients of TypeII diabetes with HbA1c levels below 7 % & above 7 %.and secondly to identify the undetected cases of anemia in TypeII diabetes. Materials & Methods - 50 patients of type 2 diabetes mellitus with their glycosylated hemoglobin levels less than 7 %, 50 patients of type 2 diabetes mellitus with their glycosylated hemoglobin levels more than 7 % attending the Medicine outpatient department of Subharti Medical College and Hospital will be the subjects for the study.50 age and sex matched controls will be selected randomly from Subharti Medical College and Hospital. Informed written consent will be taken from all the subjects. The study will be conducted from January 2016 to January. Result - We studied 50 cases with HbA1C>7(poor control),50 cases with HbA1C 5.6 to7 (good control) and 50 controls with HbA1C ≤5.6, we observed in cases with HbA1C>7 (poorly control) ,the mean HbA1C is 9.9±2 and mean Hb is 9.8±1.3 as compared to cases with HbA1C 5.6 to 7(good control) where mean HbA1C is 6±0.4 and Hb is 13±0.5,this clearly indicates that in cases HbA1C is more Hb levels are low and when HbA1C is less Hb levels are higher. Conclusion - In the present study we found negative correlation between HbA1c & Hb levels. As the value of HbA1c increases, as in cases of HbA1c >7(poor diabetic control), we found low Hb levels as compared to the cases with HbA1c <7(5.6-7) (good control).

Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats

Epigenomics ◽  
2021 ◽  
Author(s):  
Marwa Matboli ◽  
Doaa Ibrahim ◽  
Amany H Hasanin ◽  
Mohamed Kamel Hassan ◽  
Eman K Habib ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Light And Electron Microscopy ◽  
Lipid Profiles ◽  
Mirna Regulation ◽  
Protein Levels

Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnetin (50 mg/kg/d) for 4 or 8 weeks. Fasting blood glucose, renal and lipid profiles were evaluated. Renal tissues were examined by light and electron microscopy. Autophagy genes ( FYCO1, ULK, TECPR1 and  WIPI2) and miR-15b, miR-34a and miR-633 were assessed by qRT-PCR, and LC3A/B by immunoblotting. Results: Isorhamnetin improved fasting blood glucose, renal and lipid profiles with increased autophagosomes in renal tissues. It suppressed miRNA regulation of autophagy genes Conclusion: We propose a molecular mechanism for the isorhamnetin renoprotective effect by modulation of autophagy epigenetic regulators.

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