scholarly journals Treatment Research on Mental Diseases of Brain Organic Mental Disorders Based on Big Data

2021 ◽  
Vol 1881 (4) ◽  
pp. 042037
Author(s):  
Dongning Zhang ◽  
Ke Men ◽  
Yonghong Ma ◽  
Mingjuan Shi ◽  
Jing Lei ◽  
...  
Keyword(s):  
Big Data ◽  
Mental Disorders ◽  
Mental Diseases ◽  
Organic Mental Disorders ◽  
Treatment Research

Targeting xanthine oxidase by natural products as a therapeutic approach for mental disorders

2020 ◽  
Vol 26 ◽  
Author(s):  
Miquel Martorell ◽  
Xavier Lucas ◽  
Pedro Alarcón-Zapata ◽  
Xavier Capó ◽  
Maria Magdalena Quetglas-Llabrés ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Small Molecules ◽  
Xanthine Oxidase ◽  
Cell Damage ◽  
Bipolar Affective Disorder ◽  
Oxidative Reaction ◽  
Mental Diseases ◽  
Potential Therapeutic Application ◽  
Increased Activity ◽  
Dietary Flavonoids

: Mental disorders comprise diverse human pathologies including depression, bipolar affective disorder, schizophrenia, and dementia that affect millions of people around the world. The causes of mental disorders are unclear but growing evidence suggests that oxidative stress and the purine/adenosine system play a key role in their development and progression. Xanthine oxidase (XO) is a flavoprotein enzyme essential for the catalysis of the oxidative hydroxylation of purines -hypoxanthine and xanthine- to generate uric acid. As a consequence of the oxidative reaction of XO, reactive oxygen species (ROS) such as superoxide and hydrogen peroxide are produced and, further, contribute to the pathogenesis of mental disorders. Altered XO activity has been associated with free radical-mediated neurotoxicity inducing cell damage and inflammation. Diverse studies reported a direct association between an increased activity of XO and diverse mental diseases including depression or schizophrenia. Small-molecule inhibitors, such as the well-known allopurinol, and dietary flavonoids, can modulate the XO activity and subsequent ROS production. In the present work, we review the available literature on XO inhibition by small molecules and their potential therapeutic application in mental disorders. In addition, we discuss the chemistry and molecular mechanism of XO inhibitors, as well as the use of structure-based and computational methods to design specific inhibitors with the capability of modulating XO activity.

The comparative analysis of clinical and social characteristics of patients with schizophrenia and organic mental disorders receiving care in partial inpatient units

2021 ◽  
pp. 394-403
Author(s):  
George Petrovich Kostyuk ◽  
Burygina Larisa Andreevna Burygina Larisa Andreevna ◽  
Andrey Yurevich Berezantsev ◽  
Valeriya Vasilyevna Surikova
Keyword(s):  
Comparative Analysis ◽  
Mental Disorders ◽  
Psychiatric Care ◽  
Psychiatric Inpatient ◽  
Inpatient Unit ◽  
Social Characteristics ◽  
Organic Mental Disorders ◽  
Spectrum Disorders ◽  
Day Hospitals ◽  
Inpatient Units

The article presents the results of a comparative analysis of the clinical and social characteristics of patients with schizophrenic spectrum disorders (SSD) and organic mental disorders (OMD) who received care in day hospitals and intensive psychiatric care units (Moscow). During the study, a random sample of 487 discharge epicrises was studied, of which 392 (80,49%) were patients with SSD and OMD, who were subjected to further analysis. The study revealed gender differences and low rates of labor and family adaptation in both nosological groups of patients. The highest percentage of patients observed on a long-term basis in neuropsychiatric dispensaries and the rate of hospitalization in a round-the-clock inpatient unit were among the patients with diagnoses of schizophrenic spectrum disorders who were treated in intensive psychiatric care units. There were significant differences in the routing of patients depending on the pathology: district psychiatrists more often refer patients with a diagnosis of schizophrenia to the intensive psychiatric care unit in order to prevent hospitalization and patients with organic mental disorders - to day hospitals for therapy selection and medical and social rehabilitation, while doctors of the round-theclock hospital – vice versa (in order to continue treatment or follow up in out-of-hospital conditions). There was also a circulation of patients between the intensive psychiatric care unit and the day hospitals. Isolated episodes of compliance violations were noted. Indicative indicators such as hospitalization in a round-the-clock psychiatric inpatient unit within a year after the discharge from partial inpatient units was low and was usually due to severe continuous forms of the disease and the formation of therapy resistance in patients. Day hospitals and departments (offices) of intensive psychiatric care in general effectively perform the functions of inpatient unit substitution.

Organic Mental Disorders

1987 ◽  
pp. 141-169
Author(s):  
Ralph E. Tarter ◽  
Andrea M. Hegedus
Keyword(s):  
Mental Disorders ◽  
Organic Mental Disorders

scholarly journals Remembering delirium

2002 ◽  
Vol 180 (1) ◽  
pp. 4-5 ◽  
Author(s):  
Simon Fleminger
Keyword(s):  
Mental Disorders ◽  
Visual Hallucinations ◽  
Organic Mental Disorders ◽  
Confusional States

Delirium is now the preferred term to describe acute confusional states and related organic mental disorders associated with acute impairment of consciousness (Gill & Mayou, 2000). No longer is delirium reserved for those states in which overactive behaviour, often with visual hallucinations, is dominant. To accommodate the broader usage, hypoactive states of delirium have been emphasised (Lipowski, 1990), particularly as these are the states most easily missed.

Mental Diseases in Peking Between 1933 and 1943

1960 ◽  
Vol 106 (442) ◽  
pp. 274-280 ◽  
Author(s):  
Liang-Wei Chu ◽  
Mei-Chen Liu
Keyword(s):  
Mental Disorders ◽  
Relative Frequency ◽  
Medical Profession ◽  
Chinese Patients ◽  
Mental Diseases

This report is based on a survey of 1,716 Chinese patients admitted to the Peking Municipal Psychopathic Hospital during the years 1933–1943. It is mainly concerned with a statistical presentation of the relative frequency of the various mental disorders and with certain other data which may be of interest to psychiatrists and other members of the medical profession.

Сellular and Molecular Mechanisms of Proinflammatory Monocytes Participation in the Pathogenesis of Mental Disorders. Part 3

Psychiatry ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 125-134
Author(s):  
E. F. Vasilyeva ◽  
O. S. Brusov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mental Disorders ◽  
Molecular Mechanisms ◽  
Microglial Cells ◽  
Inflammatory Reactions ◽  
Mental Diseases ◽  
The Central Nervous System ◽  
The Brain

Background: at present, the important role of the monocyte-macrophage link of immunity in the pathogenesis of mental diseases has been determined. In the first and second parts of our review, the cellular and molecular mechanisms of activation of monocytes/macrophages, which secreting proinflammatory CD16 receptors, cytokines, chemokines and receptors to them, in the development of systemic immune inflammation in the pathogenesis of somatic diseases and mental disorders, including schizophrenia, bipolar affective disorder (BAD) and depression were analyzed. The association of high levels of proinflammatory activity of monocytes/macrophages in patients with mental disorders with somatic comorbidity, including immune system diseases, is shown. It is known that proinflammatory monocytes of peripheral blood, as a result of violation of the integrity of the hematoencephalic barrier can migrate to the central nervous system and activate the resident brain cells — microglia, causing its activation. Activation of microglia can lead to the development of neuroinammation and neurodegenerative processes in the brain and, as a result, to cognitive disorders. The aim of review: to analyze the results of the main scientific studies concerning the role of cellular and molecular mechanisms of peripheral blood monocytes interaction with microglial cells and platelets in the development of neuroinflammation in the pathogenesis of mental disorders, including Alzheimer’s disease (AD). Material and methods: keywords “mental disorders, AD, proinflammatory monocytes, microglia, neuroinflammation, cytokines, chemokines, cell adhesion molecules, platelets, microvesicles” were used to search for articles of domestic and foreign authors published over the past 30 years in the databases PubMed, eLibrary, Science Direct and EMBASE. Conclusion: this review analyzes the results of studies which show that monocytes/macrophages and microglia have similar gene expression profiles in schizophrenia, BAD, depression, and AD and also perform similar functions: phagocytosis and inflammatory responses. Monocytes recruited to the central nervous system stimulate the increased production of proinflammatory cytokines IL-1, IL-6, tumor necrosis factor alpha (TNF-α), chemokines, for example, MCP-1 (Monocyte chemotactic protein-1) by microglial cells. This promotes the recruitment of microglial cells to the sites of neuronal damage, and also enhances the formation of the brain protein beta-amyloid (Aβ). The results of modern studies are presented, indicating that platelets are involved in systemic inflammatory reactions, where they interact with monocytes to form monocyte-platelet aggregates (MTA), which induce the activation of monocytes with a pro inflammatory phenotype. In the last decade, it has been established that activated platelets and other cells of the immune system, including monocytes, detached microvesicles (MV) from the membrane. It has been shown that MV are involved as messengers in the transport of biologically active lipids, cytokines, complement, and other molecules that can cause exacerbation of systemic inflammatory reactions. The presented review allows us to expand our knowledge about the cellular and molecular aspects of the interaction of monocytes/macrophages with microglial cells and platelets in the development of neuroinflammation and cognitive decline in the pathogenesis of mental diseases and in AD, and also helps in the search for specific biomarkers of the clinical severity of mental disorder in patients and the prospects for their response to treatment.

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