Optimization of binding B-lymphocytes in a microfluidic channel: surface modification, stasis time and shear response

2017 ◽  
Vol 10 (1) ◽  
pp. 014101 ◽  
Author(s):  
Scott McCormick ◽  
Ziqiu Tong ◽  
Angela Ivask ◽  
Mariana Morozesk ◽  
Nicolas H Voelcker ◽  
...  
Keyword(s):  
Surface Modification ◽  
B Lymphocytes ◽  
Microfluidic Channel ◽  
Shear Response ◽  
Channel Surface

scholarly journals Single-step fabrication of microfluidic channels filled with nanofibrous membrane using femtosecond laser irradiation

2021 ◽  
Author(s):  
Amirhossein Tavangar ◽  
Bo Tan ◽  
Krishnan Venkatakrishnan
Keyword(s):  
Femtosecond Laser ◽  
Laser Irradiation ◽  
Microfluidic Channel ◽  
Scanning Speed ◽  
Single Step ◽  
Femtosecond Laser Irradiation ◽  
Microfluidic Channels ◽  
Ambient Conditions ◽  
Nanofibrous Structure ◽  
Channel Surface

In this paper, we demonstrate a new method of fabricating silicon microfluidic channels filled with a porous nanofibrous structure utilizing a femtosecond laser. The nanofibrous structure can act as a membrane used for microfiltration. This method allows us to generate both the microfluidic channel and the fibrous nanostructure in a single step under ambient conditions. Due to laser irradiation, a large number of nanoparticles ablate from the channel surface, and then aggregate and grow into porous nanofibrous structures and fill the channels. Energy dispersive x-ray spectroscopy (EDS) analysis was conducted to examine the oxygen concentration in the membrane structure. Our results demonstrated that by controlling the laser parameters including pulse repetition, pulse width and scanning speed, different microfluidic channels with a variety of porosity could be obtained.

Pore channel surface modification for enhancing anti-fouling membrane distillation

2018 ◽  
Vol 443 ◽  
pp. 217-226 ◽  
Author(s):  
Haoran Qiu ◽  
Yuelian Peng ◽  
Lei Ge ◽  
Byron Villacorta Hernandez ◽  
Zhonghua Zhu
Keyword(s):  
Surface Modification ◽  
Membrane Distillation ◽  
Pore Channel ◽  
Channel Surface

scholarly journals Surface Modification of Parylene C Film via Buchwald–Hartwig Amination for Organic Solvent‐Compatible and Flexible Microfluidic Channel Bonding

2021 ◽  
Vol 42 (8) ◽  
pp. 2170024
Author(s):  
Chinnadurai Satheeshkumar ◽  
Bum‐Joon Jung ◽  
Hansol Jang ◽  
Wonhee Lee ◽  
Myungeun Seo
Keyword(s):  
Surface Modification ◽  
Organic Solvent ◽  
Microfluidic Channel ◽  
Parylene C ◽  
Channel Bonding

scholarly journals Single-step fabrication of microfluidic channels filled with nanofibrous membrane using femtosecond laser irradiation

2021 ◽  
Author(s):  
Amirhossein Tavangar ◽  
Bo Tan ◽  
Krishnan Venkatakrishnan
Keyword(s):  
Femtosecond Laser ◽  
Laser Irradiation ◽  
Microfluidic Channel ◽  
Scanning Speed ◽  
Single Step ◽  
Femtosecond Laser Irradiation ◽  
Microfluidic Channels ◽  
Ambient Conditions ◽  
Nanofibrous Structure ◽  
Channel Surface

In this paper, we demonstrate a new method of fabricating silicon microfluidic channels filled with a porous nanofibrous structure utilizing a femtosecond laser. The nanofibrous structure can act as a membrane used for microfiltration. This method allows us to generate both the microfluidic channel and the fibrous nanostructure in a single step under ambient conditions. Due to laser irradiation, a large number of nanoparticles ablate from the channel surface, and then aggregate and grow into porous nanofibrous structures and fill the channels. Energy dispersive x-ray spectroscopy (EDS) analysis was conducted to examine the oxygen concentration in the membrane structure. Our results demonstrated that by controlling the laser parameters including pulse repetition, pulse width and scanning speed, different microfluidic channels with a variety of porosity could be obtained.

Altered Fine Structure of B Lymphocytes Correlated with Defective Terminal Differentiation

1973 ◽  
Vol 31 ◽  
pp. 386-387
Author(s):  
Dale E. Bockman ◽  
L. Y. Frank Wu ◽  
Alexander R. Lawton ◽  
Max D. Cooper
Keyword(s):  
Immune Deficiency ◽  
B Lymphocytes ◽  
Plasma Cells ◽  
Present Report ◽  
Specific Antigen ◽  
Terminal Differentiation ◽  
Second Stage ◽  
Two Stages ◽  
Deficiency Diseases ◽  
Cell Line Generation

B-lymphocytes normally synthesize small amounts of immunoglobulin, some of which is incorporated into the cell membrane where it serves as receptor of antigen. These cells, on contact with specific antigen, proliferate and differentiate to plasma cells which synthesize and secrete large quantities of immunoglobulin. The two stages of differentiation of this cell line (generation of B-lymphocytes and antigen-driven maturation to plasma cells) are clearly separable during ontogeny and in some immune deficiency diseases. The present report describes morphologic aberrations of B-lymphocytes in two diseases in which second stage differentiation is defective.

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