Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-Acetylcarnitine: Insights Into the Mechanisms of Action of This Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress

Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. miltiorrhiza, including inflammation, fibrosis, oxidative stress, and apoptosis. The findings on multi-functional properties of S. miltiorrhiza discussed in this article support the efficacy of S. miltiorrhiza extract on various diseases, but also call for further research on the multiple mechanisms that mediate its therapeutic effects.

Download Full-text

Depolarization and cardiolipin depletion in aged rat brain mitochondria: Relationship with oxidative stress and electron transport chain activity

Neurochemistry International ◽

10.1016/j.neuint.2007.01.007 ◽

2007 ◽

Vol 50 (5) ◽

pp. 719-725 ◽

Cited By ~ 50

Author(s):

Tanusree Sen ◽

Nilkantha Sen ◽

Sirsendu Jana ◽

Firoj Hossain Khan ◽

Uttara Chatterjee ◽

...

Keyword(s):

Oxidative Stress ◽

Electron Transport ◽

Rat Brain ◽

Electron Transport Chain ◽

Brain Mitochondria ◽

Aged Rat ◽

Rat Brain Mitochondria ◽

Transport Chain

Download Full-text

Modification by vitamin E and exercise of oxidative stress in regions of aging rat brain: Studies on superoxide dismutase isoenzymes and protein oxidation status

Experimental Gerontology ◽

10.1016/j.exger.2006.04.007 ◽

2006 ◽

Vol 41 (8) ◽

pp. 753-763 ◽

Cited By ~ 64

Author(s):

A.B. Jolitha ◽

M.V.V. Subramanyam ◽

S. Asha Devi

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Vitamin E ◽

Rat Brain ◽

Protein Oxidation ◽

Aging Rat ◽

Oxidation Status

Download Full-text

Attenuated transcriptional responses to oxidative stress in the aged rat brain

Journal of Neuroscience Research ◽

10.1002/jnr.10428 ◽

2002 ◽

Vol 70 (3) ◽

pp. 318-326 ◽

Cited By ~ 12

Author(s):

LiQi Tong ◽

Tracy Toliver-Kinsky ◽

Michael Edwards ◽

David K. Rassin ◽

Karin Werrbach-Perez ◽

...

Keyword(s):

Oxidative Stress ◽

Rat Brain ◽

Transcriptional Responses ◽

Aged Rat

Download Full-text

Ellagic Acid: A Logical Lead for Drug Development?

Current Pharmaceutical Design ◽

10.2174/1381612823666171115094557 ◽

2018 ◽

Vol 24 (2) ◽

pp. 106-122 ◽

Cited By ~ 7

Author(s):

Abolfazl Shakeri ◽

Mohammad Reza Zirak ◽

Amirhossein Sahebkar

Keyword(s):

Oxidative Stress ◽

Ellagic Acid ◽

Therapeutic Agent ◽

Biological Activities ◽

Biological Properties ◽

Mechanisms Of Action ◽

Human Diseases ◽

Pharmacological Properties ◽

Naturally Occurring ◽

The Subject

Background: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid. Methods: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications. Results: EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins). EA exhibits many biological properties such as antioxidant, anti-diabetic, anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases. Conclusion: Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer.

Download Full-text