Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems

2021 ◽  
Author(s):  
Lingfei Wang ◽  
Feng Jin ◽  
Xiqian Jiang ◽  
Jianwei Chen ◽  
Meng C Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fluorescent Probes ◽  
Biological Systems

Real-Time Mass Spectrometry Measurements of Respiration Rates in Biological Systems

2020 ◽  
Author(s):  
Karl K. Weitz ◽  
Montana L. Smith ◽  
Kim K. Hixson ◽  
Eric A. Hill ◽  
Janet K. Jansson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Real Time ◽  
Biological Systems ◽  
Respiration Rates

scholarly journals Transformative opportunities for single-cell proteomics

2018 ◽  
Author(s):  
Harrison Specht ◽  
Nikolai Slavov
Keyword(s):  
Mass Spectrometry ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Single Cell ◽  
Single Cells ◽  
Biological Systems ◽  
Stem Cell Differentiation ◽  
New Age ◽  
Technological Developments

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to transcend these limitations by developing powerful methods to routinely quantify thousands of proteins and proteoforms across many thousands of single cells. We outline specific technological developments and ideas that can increase the sensitivity and throughput of single cell MS by orders of magnitude and usher in this new age. These advances will transform medicine and ultimately contribute to understanding biological systems on an entirely new level.

scholarly journals Global and site‐specific analysis of protein glycosylation in complex biological systems with Mass Spectrometry

2019 ◽  
Vol 38 (4-5) ◽  
pp. 356-379 ◽  
Author(s):  
Haopeng Xiao ◽  
Fangxu Sun ◽  
Suttipong Suttapitugsakul ◽  
Ronghu Wu
Keyword(s):  
Mass Spectrometry ◽  
Biological Systems ◽  
Protein Glycosylation ◽  
Site Specific ◽  
Specific Analysis

scholarly journals Identification of nanoparticles and their localization in algal biofilm by 3D-imaging secondary ion mass spectrometry

2019 ◽  
Vol 34 (6) ◽  
pp. 1098-1108 ◽  
Author(s):  
Pietro Benettoni ◽  
Hryhoriy Stryhanyuk ◽  
Stephan Wagner ◽  
Felix Kollmer ◽  
Jairo H. Moreno Osorio ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
3D Imaging ◽  
Secondary Ion Mass Spectrometry ◽  
Biological Systems ◽  
Chemical Imaging ◽  
Resolving Power ◽  
Tof Sims ◽  
Mass Resolving Power ◽  
Algal Biofilm ◽  
Secondary Ion

ToF-SIMS boundaries were pushed to enhance lateral resolution and mass resolving power for chemical imaging of nanoparticles in biological systems.

scholarly journals Rational design of small molecule fluorescent probes for biological applications

2020 ◽  
Vol 18 (30) ◽  
pp. 5747-5763 ◽  
Author(s):  
Joomyung V. Jun ◽  
David M. Chenoweth ◽  
E. James Petersson
Keyword(s):  
Energy Transfer ◽  
Small Molecule ◽  
Fluorescent Probes ◽  
Rational Design ◽  
Biological Systems ◽  
Biological Applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

scholarly journals Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

2020 ◽  
Vol 11 (20) ◽  
pp. 5127-5141 ◽  
Author(s):  
Mingwang Yang ◽  
Jiangli Fan ◽  
Jianjun Du ◽  
Xiaojun Peng
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Biological Systems ◽  
Design Principles ◽  
Signaling Molecules ◽  
Gaseous Signaling Molecules

This perspective article aims to introduce the design principles and recognition strategies of small-molecule fluorescent probes which are applied for the detection of gas signaling molecules including NO, CO and H2S in biological systems.

Metabolomics and proteomics technologies to explore the herbal preparation affecting metabolic disorders using high resolution mass spectrometry

2017 ◽  
Vol 13 (2) ◽  
pp. 320-329 ◽  
Author(s):  
Aihua Zhang ◽  
Xiaohang Zhou ◽  
Hongwei Zhao ◽  
Shiyu Zou ◽  
Chung Wah Ma ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Metabolic Disorders ◽  
High Resolution Mass Spectrometry ◽  
Biological Systems ◽  
Herbal Preparation ◽  
High Resolution Mass ◽  
Proteomics Approach ◽  
Resolution Mass

An integrative metabolomics and proteomics approach can provide novel insights in the understanding of biological systems.

Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems

2017 ◽  
Vol 90 (1) ◽  
pp. 533-555 ◽  
Author(s):  
Xiaoyun Jiao ◽  
Yong Li ◽  
Jinye Niu ◽  
Xilei Xie ◽  
Xu Wang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Biological Systems ◽  
Reactive Oxygen ◽  
Sulfur Species

scholarly journals Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Kyle L. Fort ◽  
Michiel van de Waterbeemd ◽  
Dmitriy Boll ◽  
Maria Reinhardt-Szyba ◽  
Mikhail E. Belov ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Structural Analysis ◽  
Mass Spectrometer ◽  
Biological Systems ◽  
Native Mass Spectrometry ◽  
Macromolecular Complexes ◽  
Insight Into

Native mass spectrometry can provide insight into the structure of macromolecular biological systems.

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