Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma

Background. Long noncoding RNAs (lncRNAs) have been shown to be involved in the mechanism of cisplatin resistance in lung adenocarcinoma (LAD). However, the roles of lncRNAs in cisplatin resistance in LAD are not well understood. Methods. We used a high-throughput microarray to compare the lncRNA and mRNA expression profiles in cisplatin resistance cell A549/DDP and cisplatin sensitive cell A549. Several candidate cisplatin resistance-associated lncRNAs were verified by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis. Results. We found that 1,543 lncRNAs and 1,713 mRNAs were differentially expressed in A549/DDP cell and A549 cell, hinting that many lncRNAs were irregular from cisplatin resistance in LAD. We also obtain the fact that 12 lncRNAs were aberrantly expressed in A549/DDP cell compared with A549 cell by quantitative PCR. Among these, UCA1 was the aberrantly expressed lncRNA and can significantly reduce the IC50 of cisplatin in A549/DDP cell after knockdown, while it can increase the IC50 of cisplatin after UCA1 was overexpressed in NCI-H1299. Conclusions. We obtained patterns of irregular lncRNAs and they may play a key role in cisplatin resistance of LAD.

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Expression profiles of long noncoding RNAs in lung adenocarcinoma

OncoTargets and Therapy ◽

10.2147/ott.s167633 ◽

2018 ◽

Vol Volume 11 ◽

pp. 5383-5390 ◽

Cited By ~ 10

Author(s):

Bing Zhao ◽

Hang Xu ◽

Xiaoye Ai ◽

Yasheng Adalat ◽

Ying Tong ◽

...

Keyword(s):

Lung Adenocarcinoma ◽

Expression Profiles ◽

Noncoding Rnas ◽

Long Noncoding Rnas

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Current Research Progress on Long Noncoding RNAs Associated with Hepatocellular Carcinoma

Analytical Cellular Pathology ◽

10.1155/2019/1534607 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Haihong Shi ◽

Yuxin Xu ◽

Xin Yi ◽

Dandan Fang ◽

Xia Hou

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Proliferation ◽

Liver Cancer ◽

Biological Activities ◽

Noncoding Rnas ◽

Long Noncoding Rnas ◽

Research Progress ◽

Invasion And Metastasis ◽

Complex Processes ◽

And Function

Hepatocellular carcinoma (HCC) is the second leading cause of mortality among cancers. It has been found that long noncoding RNAs (lncRNAs) are involved in many human cancers, including liver cancer. It has been identified that carcinogenic and tumor-suppressing lncRNAs are associated with complex processes in liver cancer. These lncRNAs may participate in a variety of pathological and biological activities, such as cell proliferation, apoptosis, invasion, and metastasis. Here, we review the regulation and function of lncRNA in liver cancer and evaluate the potential of lncRNA as a new goal for liver cancer.

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A Prognostic Signature of Glycolysis-Related Long Noncoding RNAs for Molecular Subtypes in the Tumor Immune Microenvironment of Lung Adenocarcinoma

International Journal of General Medicine ◽

10.2147/ijgm.s340615 ◽

2021 ◽

Vol Volume 14 ◽

pp. 8955-8974

Author(s):

Na Li ◽

Mu Su ◽

Louyin Zhu ◽

Li Wang ◽

Yonggang Peng ◽

...

Keyword(s):

Lung Adenocarcinoma ◽

Molecular Subtypes ◽

Noncoding Rnas ◽

Long Noncoding Rnas ◽

Prognostic Signature ◽

Immune Microenvironment ◽

Tumor Immune Microenvironment

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Detection of the long noncoding RNAs nuclear-enriched autosomal transcript 1 (NEAT1) and metastasis associated lung adenocarcinoma transcript 1 in the peripheral blood of HIV-1-infected patients

HIV Medicine ◽

10.1111/hiv.12276 ◽

2015 ◽

Vol 17 (1) ◽

pp. 68-72 ◽

Cited By ~ 23

Author(s):

C Jin ◽

X Peng ◽

T Xie ◽

X Lu ◽

F Liu ◽

...

Keyword(s):

Lung Adenocarcinoma ◽

Peripheral Blood ◽

Noncoding Rnas ◽

Long Noncoding Rnas ◽

Hiv 1

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E2F1-Induced lncRNA BAIAP2-AS1 Overexpression Contributes to the Malignant Progression of Hepatocellular Carcinoma via miR-361-3p/SOX4 Axis

Disease Markers ◽

10.1155/2021/6256369 ◽

2021 ◽

Vol 2021 ◽

pp. 1-18

Author(s):

Yan Yang ◽

Hong Ge ◽

De-qing Li ◽

Ai-xia Xu

Keyword(s):

Hepatocellular Carcinoma ◽

Therapeutic Target ◽

Antisense Rna ◽

Noncoding Rnas ◽

Malignant Progression ◽

Long Noncoding Rnas ◽

Positive Interaction ◽

Potential Therapeutic Target ◽

Proliferation And Metastasis ◽

Hcc Cells

Currently, plenty of researches have revealed that long noncoding RNAs (lncRNAs) can act as crucial roles during the progression of various tumors, including hepatocellular carcinoma (HCC). Here, we measured the expression of lncRNA BAIAP2 antisense RNA 1(BAIAP2-AS1) as well as its contribution to the developments of HCC. In this study, the expressions of BAIAP2-AS1 and SOX4 were distinctly upregulated in HCC cells and tissues, and high BAIAP2-AS1 may be a novel biomarker for HCC. E2F1 activated BAIAP2-AS1 expression. The silence of BAIAP2-AS1 inhibited the proliferation and metastasis of HepG2 and PLC5 cells. Assays for relationship verification showed that BAIAP2-AS1 regulated the expression of SOX4 and miR-361-3p. Rescue experiments further confirmed the positive interaction between miR-361-3p and BAIAP2-AS1 as well as between miR-361-3p and SOX4. Overall, BAIAP2-AS1 modulated the miR-361-3p/SOX4 axis to promote the development of HCC. Thus, our study offers a potential therapeutic target for treating HCC.

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