Dosage Predictions in High-Dose Methotrexate Infusions Part 2: Bayesian Estimation of Methotrexate Clearance

1985 ◽  
Vol 2 (4) ◽  
pp. 277-283 ◽  
Author(s):  
R. BRUNO ◽  
A. ILIADIS ◽  
R. FAVRE ◽  
N. LENA ◽  
A.M. IMBERT ◽  
...  
Keyword(s):  
Bayesian Estimation ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

Bayesian estimation and prediction of clearance in high-dose methotrexate infusions

1985 ◽  
Vol 13 (1) ◽  
pp. 101-115 ◽  
Author(s):  
Athanassios Iliadis ◽  
Maachou Bachir-Raho ◽  
René Bruno ◽  
Roger Favre
Keyword(s):  
Bayesian Estimation ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Estimation And Prediction ◽  
Dose Methotrexate

Dosage Adjustment of High-Dose Methotrexate Using Bayesian Estimation

1995 ◽  
Vol 17 (5) ◽  
pp. 471-478 ◽  
Author(s):  
Thierry Pignon ◽  
Bruno Lacarelle ◽  
Florence Duffaud ◽  
Pierre Guillet ◽  
Jacques Catalin ◽  
...  
Keyword(s):  
Bayesian Estimation ◽  
Dosage Adjustment ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

High-dose methotrexate-induced reversible grade 4 hyperbilirubinaemia and transaminitis in an adolescent with Burkitt Leukaemia

2021 ◽  
Vol 14 (1) ◽  
pp. e237512
Author(s):  
Sanjeev Khera ◽  
Randhir Ranjan ◽  
Sateesh Ramachandran ◽  
Ajay Beriwal
Keyword(s):  
Liver Injury ◽  
Clinical Significance ◽  
Short Latency ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Drug Induced ◽  
Common Cause ◽  
Drug Induced Liver Injury ◽  
Dose Methotrexate

Symptomatic drug-induced liver injury (DILI) is an uncommon problem. Direct DILI is dose-related, predictable with short latency (hour to days) and is generally associated with transient and reversible transaminitis without jaundice. Antimetabolites including methotrexate are a common cause for direct DILI. Hepatotoxicity associated with high-dose methotrexate (HD-MTX) is generally transient and includes reversible elevation of transaminase in up to 60% and associated hyperbilirubinaemia (≤grade 2) in 25% of courses and therefore is of no clinical significance. Severe grades of DILI with HD-MTX (grade ≥4) are extremely rare. We describe an adolescent with Burkitt leukaemia who had reversible grade 4 DILI including hyperbilirubinaemia postfirst course of HD-MTX. Rechallenge with two-third dose of HD-MTX in subsequent chemotherapeutic cycle did not cause recurrence of DILI.

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