scholarly journals Article Commentary: Sex- and Gender-Based Medicine: The Need for Precise Terminology

2017 ◽  
Vol 1 (3) ◽  
pp. 122-128 ◽  
Author(s):  
Tracy E. Madsen ◽  
Ghada Bourjeily ◽  
Memoona Hasnain ◽  
Marjorie Jenkins ◽  
Mary F. Morrison ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Health Professions ◽  
Sex And Gender ◽  
Medical Specialties ◽  
Health And Disease ◽  
Gender Based ◽  
And Gender ◽  
Based Medicine ◽  
The Impact ◽  
Sex And Gender Differences

As our knowledge of sex- and gender-based medicine (SGBM) continues to grow, attention to precision in the use of related terminology is critical. Unfortunately, the terms sex and gender are often used interchangeably and incorrectly, both within and outside of the typical binary construct. On behalf of the Sex and Gender Women's Health Collaborative (SGWHC), a national organization whose mission is the integration of SGBM into research, health professions education, and clinical practice, our objective was to develop recommendations for the accurate use of SGBM terminology in research and clinical practice across medical specialties and across health professions. In addition, we reviewed the origins and evolution of SGBM terminology and described terms used when referring to individuals outside the typical binary categorization of sex and gender. Standardization and precision in the use of sex and gender terminology will lead to a greater understanding and appropriate translation of sex and gender evidence to patient care along with an accurate assessment of the impact sex and gender have on patient outcomes. In addition, it is critical to acknowledge that SGBM terminology will continue to evolve and become more precise as our knowledge of sex and gender differences in health and disease progresses.

Sex and gender differences in Alzheimer’s disease: current challenges and implications for clinical practice

2020 ◽  
Vol 27 (6) ◽  
pp. 928-943 ◽  
Author(s):  
M. T. Ferretti ◽  
J. Martinkova ◽  
E. Biskup ◽  
T. Benke ◽  
G. Gialdini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Differences ◽  
Clinical Practice ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences

scholarly journals Gender-specific aspects of epidemiology, molecular genetics and outcome: lung cancer

ESMO Open ◽  
2020 ◽  
Vol 5 (Suppl 4) ◽  
pp. e000796
Author(s):  
Nuria Mederos ◽  
Alex Friedlaender ◽  
Solange Peters ◽  
Alfredo Addeo
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Lung Cancer ◽  
Gender Differences ◽  
Sex And Gender ◽  
Never Smokers ◽  
And Gender ◽  
The Impact ◽  
Gender Specific ◽  
Sex And Gender Differences

Lung cancer remains the leading cause of cancer-related deaths worldwide in women and men. In incidence, lung cancer ranks second, surpassed by breast cancer in women and prostate cancer in men. However, the historical differences in mortality and incidence rate between both sexes have changed in the last years. In the last decades, we have also witnessed an increased number of lung cancer in female never-smokers. These disparities have grown our interest in studying the impact of the gender and sex in the presentation of lung cancer. The aetiology is yet to be fully elucidated, but the data are clear so far: there is a growing divide between lung cancer presentation in women and men that will change our management and study of lung cancer. This article aims to review the sex and gender differences in lung cancer.

The Impact of Sex and Gender on Heart-Brain Axis Dysfunction: Current Concepts and Novel Perspectives

2020 ◽  
Author(s):  
Carlotta Baroni ◽  
Vincenzo Lionetti
Keyword(s):  
Age Of Onset ◽  
Treatment Strategies ◽  
Organ Injury ◽  
Sex And Gender ◽  
Male Population ◽  
Female Population ◽  
Determining Factors ◽  
Gender Based ◽  
And Gender ◽  
The Impact

The Heart-Brain Axis (HBA) recapitulates all the circuits that regulate bidirectional flow of communication between heart and brain. Several mechanisms may underlie the interdependent relationship involving heterogeneous tissues at rest and during specific target organ injury, such as myocardial infarction, heart failure, arrhythmia, stroke, mood disorders or dementia. In-depth translational studies of the HBA dysfunction under single-organ injury should include both male and female animals to develop sex/gender-oriented prevention, diagnosis and treatment strategies. Indeed, sex and gender are determining factors since females and males exhibit significant differences in terms of susceptibility to risk factors, age of onset, severity of symptoms and outcome. Despite most studies have focused on the male population, we have conducted a careful appraisal of the literature investigating HBA in females. In particular, we have i) analysed sex-related heart and brain illnesses, ii) recapitulated the most significant studies simultaneously conducted on cardio- and cerebrovascular systems in female population, iii) hypothesised future perspectives for the development of gender-based approach to HBA dysfunction. Although sex/gender-oriented research is at its infancy, the impact of sex on HBA dysfunction is opening unexpected new avenues for managing health of female subjects exposed to risk of lifestyle multi-organ disease.

scholarly journals Engaging Emergency Medicine Influencers in Sex‐ and Gender‐based Medicine: Lessons Learned from the Sex and Gender Interest Group in Emergency Medicine and the SAEM Jeopardy Game

2019 ◽  
Vol 4 (2) ◽  
pp. 161-165
Author(s):  
Jeannette Wolfe ◽  
Basmah Safdar ◽  
Kinjal N. Sethuraman ◽  
Marna R. Greenberg ◽  
Tracy E. Madsen ◽  
...  
Keyword(s):  
Emergency Medicine ◽  
Interest Group ◽  
Lessons Learned ◽  
Sex And Gender ◽  
Gender Based ◽  
And Gender ◽  
Based Medicine

scholarly journals Stratification by Sex and Hormone Level When Contrasting Men and Women in Schizophrenia Trials Will Improve Personalized Treatment

2021 ◽  
Vol 11 (9) ◽  
pp. 929
Author(s):  
Mary V. Seeman ◽  
Alexandre González-Rodríguez
Keyword(s):  
Small Samples ◽  
Sexually Dimorphic ◽  
Sex And Gender ◽  
Female Hormone ◽  
Hormone Levels ◽  
Epidemiologic Evidence ◽  
Improved Outcomes ◽  
And Gender ◽  
The Impact ◽  
Sex And Gender Differences

Background: Sex and gender differences have been reported in the prevalence, expression, treatment response, and outcome of schizophrenia, but most reports are based on relatively small samples that have not been stratified for the impact of sex hormone levels. This literature review aims to show how women’s hormone levels can impact the results of male/female comparisons. Methods: This is a narrative review of data from publications of the last decade. Results: Epidemiologic evidence, reports of the impact of hormones on cognition, results of sexually dimorphic responses to treatment, and male/female trajectories of illness over time all suggest that female hormone fluctuations exert major effects on male/female differences in schizophrenia. Conclusions: Information on hormonal status in women participants is rarely available in clinical studies in schizophrenia, which makes male/female comparisons largely uninterpretable. These are the current challenges. Opportunities for individualized treatment are growing, however, and will undoubtedly result in improved outcomes for both women and men in the future.

scholarly journals Still Blurred: Sex and Gender Based Medicine Approach

2019 ◽  
Vol 17 (3) ◽  
pp. 350-361
Author(s):  
Yesim YASİN ◽  
Erkin AYDEMİR ◽  
İrem ŞEVİK ◽  
Ezgi ÖZYALÇIN
Keyword(s):  
Sex And Gender ◽  
Gender Based ◽  
And Gender ◽  
Based Medicine
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