Preclinical safety evaluation of a recombinant plasmid vector encoding mature human neutrophil peptide-1 by repeated local administrations in nonhuman primates

2021 ◽  
Author(s):  
DAN LI ◽  
Fuchun Guo ◽  
Ke Chen ◽  
Xunning Yang ◽  
Yongsheng Wang
Keyword(s):  
Human Neutrophil ◽  
Recombinant Plasmid ◽  
Nonhuman Primates ◽  
Safety Evaluation ◽  
Plasmid Vector ◽  
Preclinical Safety ◽  
Human Neutrophil Peptide

Preclinical safety evaluation of nafithromycin (WCK 4873) with emphasis on liver safety in rat and dog

2021 ◽  
Vol 122 ◽  
pp. 104889
Author(s):  
Manohar Nandanwar ◽  
Rajesh Chavan ◽  
Atul Kansagara ◽  
Muftedar Ahmed Patel ◽  
Anasuya Patel ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Liver Safety ◽  
Preclinical Safety

scholarly journals Placental Mesenchymal Stromal Cells: Preclinical Safety Evaluation for Fetal Myelomeningocele Repair

2021 ◽  
Vol 267 ◽  
pp. 660-668
Author(s):  
Jordan E Jackson ◽  
Christopher Pivetti ◽  
Sarah C Stokes ◽  
Christina M Theodorou ◽  
Priyadarsini Kumar ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Safety Evaluation ◽  
Myelomeningocele Repair ◽  
Preclinical Safety

scholarly journals Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1

2014 ◽  
Vol 193 (12) ◽  
pp. 6144-6151 ◽  
Author(s):  
Linda A. Stevens ◽  
Joseph T. Barbieri ◽  
Grzegorz Piszczek ◽  
Amy N. Otuonye ◽  
Rodney L. Levine ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Biological Activities ◽  
Human Neutrophil Peptide

scholarly journals BIPOLAR MULTI-ELECTRODE BALLOON CATHETER RADIOFREQUENCY RENAL DENERVATION WITH THE VESSIX SYSTEM: PRECLINICAL SAFETY EVALUATION

2014 ◽  
Vol 63 (12) ◽  
pp. A2085
Author(s):  
Gregory J. Wilson ◽  
Dawn Winsor-Hines ◽  
Radhika Tunstall ◽  
Barbara Huibregtse ◽  
Liza Davis ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Balloon Catheter ◽  
Safety Evaluation ◽  
Preclinical Safety

Preclinical safety evaluation of human platelets treated with antimicrobial peptides in severe combined immunodeficient mice

Transfusion ◽  
2013 ◽  
Vol 54 (3) ◽  
pp. 569-576 ◽  
Author(s):  
Marta Bosch-Marcé ◽  
Ketha V.K. Mohan ◽  
Monique P. Gelderman ◽  
Patricia L. Ryan ◽  
Estelle Russek-Cohen ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Safety Evaluation ◽  
Human Platelets ◽  
Immunodeficient Mice ◽  
Preclinical Safety

scholarly journals Therapeutic Potential of Human Neutrophil Peptide 1 against Experimental Tuberculosis

2001 ◽  
Vol 45 (2) ◽  
pp. 639-640 ◽  
Author(s):  
Sudhir Sharma ◽  
Indu Verma ◽  
G. K. Khuller
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Human Neutrophil ◽  
Therapeutic Efficacy ◽  
Therapeutic Potential ◽  
Therapeutic Activity ◽  
Experimental Tuberculosis ◽  
Dose Dependent ◽  
Different Doses ◽  
Human Neutrophil Peptide

ABSTRACT The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against experimental tuberculosis in mice on the basis of numbers of CFU has been examined. Mice infected with 1.5 × 104CFU of Mycobacterium tuberculosisH37Rv and treated with different doses of HNP-1 injected subcutaneously exhibited significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, livers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic activity of HNP-1 against tuberculosis.

Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats

2018 ◽  
Vol 118 ◽  
pp. 1-12 ◽  
Author(s):  
Gustavo Roberto Villas Boas ◽  
Ariany Carvalho dos Santos ◽  
Roosevelt Isaias Carvalho Souza ◽  
Flávio Henrique Souza de Araújo ◽  
Giseli Karenina Traesel ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Ethanolic Extract ◽  
Experimental Models ◽  
Short Term ◽  
Preclinical Safety

scholarly journals Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shady Kotb ◽  
Joao Piraquive ◽  
Franck Lamberton ◽  
François Lux ◽  
Michael Verset ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Safety Evaluation ◽  
Imaging Properties
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