Therapeutic Potential of Human Neutrophil Peptide 1 against Experimental Tuberculosis
2001 ◽
Vol 45
(2)
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pp. 639-640
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Keyword(s):
ABSTRACT The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against experimental tuberculosis in mice on the basis of numbers of CFU has been examined. Mice infected with 1.5 × 104CFU of Mycobacterium tuberculosisH37Rv and treated with different doses of HNP-1 injected subcutaneously exhibited significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, livers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic activity of HNP-1 against tuberculosis.
2000 ◽
Vol 16
(1)
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pp. 112
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1993 ◽
Vol 69
(02)
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pp. 157-163
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Keyword(s):
2019 ◽
Vol 20
(9)
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pp. 885-892