A Canola Oil-Supplemented Diet Prevents Type I Diabetes-Caused Lipotoxicity and Renal Dysfunction in a Rat Model

2016 ◽  
Vol 19 (11) ◽  
pp. 1041-1047 ◽  
Author(s):  
Edgar Cano-Europa ◽  
Rocio Ortiz-Butron ◽  
Estela Melendez Camargo ◽  
María Miriam Esteves-Carmona ◽  
Rosa Maria Oliart-Ros ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Rat Model ◽  
Canola Oil ◽  
Type I Diabetes ◽  
Type I

scholarly journals Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Saad Mohamed Asseri ◽  
Nehal M. Elsherbiny ◽  
Mohamed El-Sherbiny ◽  
Iman O. Sherif ◽  
Alsamman M. Alsamman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Glycyrrhizic Acid ◽  
Type I Diabetes ◽  
Vascular Dysfunction ◽  
Type I ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Ameliorative Effect ◽  
Related Proteins

AbstractThe burden of diabetes mellitus (DM) and associated complications is increasing worldwide, affecting many organ functionalities including submandibular glands (SMG). The present study aims to investigate the potential ameliorative effect of glycyrrhizic acid (GA) on diabetes-induced SMG damage. Experimental evaluation of GA treatment was conducted on a rat model of type I diabetes. Animals were assigned to three groups; control, diabetic and GA treated diabetic groups. After 8 weeks, the SMG was processed for assessment of oxidative stress markers, autophagy related proteins; LC3, Beclin-1 and P62, vascular regulator ET-1, aquaporins (AQPs 1.4 and 5), SIRT1 protein expressions in addition to LC3 and AQP5 mRNA expressions. Also, parenchymal structures of the SMG were examined. GA alleviated the diabetes-induced SMG damage via restoring the SMG levels of oxidative stress markers and ET-1 almost near to the normal levels most probably via regulation of SIRT1, AQPs and accordingly LC-3, P62 and Beclin-1levels. GA could be a promising candidate for the treatment of diabetes-induced SMG damage via regulating oxidative stress, autophagy and angiogenesis.

Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model

2020 ◽  
Vol 227 ◽  
pp. 151419
Author(s):  
Elisa J. Campos ◽  
João Martins ◽  
Dan Brudzewsky ◽  
David P.D. Woldbye ◽  
António F. Ambrósio
Keyword(s):  
Neuropeptide Y ◽  
Mrna Expression ◽  
Rat Model ◽  
Type I Diabetes ◽  
Type I

scholarly journals Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Min Xie ◽  
Meijian Wang ◽  
Wei Liu ◽  
Min Xu ◽  
Pan Shang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Rat Model ◽  
Type I Diabetes ◽  
Type I ◽  
Protective Effects ◽  
Diabetic Encephalopathy ◽  
Neuroprotective Effects ◽  
Lim Kinase ◽  
Ca1 Region

Diabetic encephalopathy is a type of central diabetic neuropathy resulting from diabetes mainly manifested as cognitive impairments. However, its underlying pathogenesis and effective treatment strategies remain unclear. In the present study, we investigated the effect of Lipin1, a phosphatidic acid phosphatase enzyme, on the pathogenesis of diabetic encephalopathy. We found that in vitro, Lipin1 exerts protective effects on high glucose-induced reductions of PC12 cell viability, while in vivo, Lipin1 is downregulated within the CA1 hippocampal region in a type I diabetes rat model. Increased levels of Lipin1 within the CA1 region are accompanied with protective effects including amelioration of dendritic spine and synaptic deficiencies, phosphorylation of the synaptic plasticity-related proteins, LIM kinase 1 (p-limk1) and cofilin, as well as increases in the synthesis of diacylglycerol (DAG), and the expression of phosphorylated protein kinase D (p-PKD). These effects are associated with the rescue of cognitive disorders as shown in this rat model of diabetes. In contrast, knockdown of Lipin1 within the CA1 region enhanced neuronal abnormalities and the genesis of cognitive impairment in rats. These results suggest that Lipin1 may exert neuroprotective effects involving the PKD/Limk/Cofilin signaling pathway and may serve as a potential therapeutic target for diabetic encephalopathy.

Evaluation of the Effects of Photobiomodulation on Biomechanical Properties and Hounsfield Unit of Partial Osteotomy Healing in an Experimental Rat Model of Type I Diabetes and Osteoporosis

2017 ◽  
Vol 35 (10) ◽  
pp. 520-529 ◽  
Author(s):  
Ataroalsadat Mostafavinia ◽  
Reza Ahadi ◽  
Mohammadamin Abdollahifar ◽  
Seyed Kamran Ghorishi ◽  
Ali Jalalifirouzkouhi ◽  
...  
Keyword(s):  
Rat Model ◽  
Type I Diabetes ◽  
Hounsfield Unit ◽  
Biomechanical Properties ◽  
Type I ◽  
Experimental Rat Model

scholarly journals 118Dysfunction of the pacemaker of the heart in the rat model of streptozotocin-induced type I diabetes mellitus

EP Europace ◽  
2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii12-iii12
Author(s):  
Y. Zhang ◽  
YW. Wang ◽  
J. Yanni ◽  
X. Cai ◽  
MA. Qureshi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Rat Model ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I

scholarly journals Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes

2012 ◽  
Vol 109 (28) ◽  
pp. 11390-11395 ◽  
Author(s):  
B. Inceoglu ◽  
K. M. Wagner ◽  
J. Yang ◽  
A. Bettaieb ◽  
N. H. Schebb ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Rat Model ◽  
Type I Diabetes ◽  
Type I
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