scholarly journals Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model

2014 ◽  
Vol 20 (1-2) ◽  
pp. 225-238 ◽  
Author(s):  
Samantha L. Wilson ◽  
Ying Yang ◽  
Alicia J. El Haj
Keyword(s):  
Stromal Cell ◽  
Three Dimensional ◽  
Cell Interactions ◽  
Cell Phenotype ◽  
Dimensional Model ◽  
Cell Plasticity ◽  
Three Dimensional Model ◽  
Cell Cell

Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis

2020 ◽  
Vol 20 (4) ◽  
pp. 484-490
Author(s):  
Mohammad Rasool Khazaei ◽  
Zahra Rashidi ◽  
Farzaneh Chobsaz ◽  
Elham Niromand ◽  
Mozafar Khazaei
Keyword(s):  
Three Dimensional ◽  
Inhibitory Effect ◽  
Endometrial Tissue ◽  
Dimensional Model ◽  
Three Dimensional Model

scholarly journals Physical confinement signals regulate the organization of stem cells in three dimensions

2016 ◽  
Vol 13 (123) ◽  
pp. 20160613 ◽  
Author(s):  
Sebastian V. Hadjiantoniou ◽  
David Sean ◽  
Maxime Ignacio ◽  
Michel Godin ◽  
Gary W. Slater ◽  
...  
Keyword(s):  
Stem Cells ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Three Dimensional ◽  
Embryonic Stem ◽  
Cell Interactions ◽  
Three Dimensions ◽  
Cell Substrate ◽  
Cell Cell

During embryogenesis, the spherical inner cell mass (ICM) proliferates in the confined environment of a blastocyst. Embryonic stem cells (ESCs) are derived from the ICM, and mimicking embryogenesis in vitro , mouse ESCs (mESCs) are often cultured in hanging droplets. This promotes the formation of a spheroid as the cells sediment and aggregate owing to increased physical confinement and cell–cell interactions. In contrast, mESCs form two-dimensional monolayers on flat substrates and it remains unclear if the difference in organization is owing to a lack of physical confinement or increased cell–substrate versus cell–cell interactions. Employing microfabricated substrates, we demonstrate that a single geometric degree of physical confinement on a surface can also initiate spherogenesis. Experiment and computation reveal that a balance between cell–cell and cell–substrate interactions finely controls the morphology and organization of mESC aggregates. Physical confinement is thus an important regulatory cue in the three-dimensional organization and morphogenesis of developing cells.

scholarly journals Mutagenesis and Molecular Modeling Reveal Three Key Extracellular Loops of the Membrane Receptor HasR That Are Involved in Hemophore HasA Binding

2007 ◽  
Vol 189 (14) ◽  
pp. 5379-5382 ◽  
Author(s):  
Clément Barjon ◽  
Karine Wecker ◽  
Nadia Izadi-Pruneyre ◽  
Philippe Delepelaire
Keyword(s):  
Molecular Modeling ◽  
Outer Membrane ◽  
Three Dimensional ◽  
Membrane Receptor ◽  
Dimensional Model ◽  
Outer Membrane Receptor ◽  
Three Dimensional Model ◽  
Extracellular Loops

ABSTRACT On the basis of the three-dimensional model of the heme/hemophore TonB-dependent outer membrane receptor HasR, mutants with six-residue deletions in the 11 putative extracellular loops were generated. Although all mutants continued to be active TonB-dependent heme transporters, mutations in three loops abolished hemophore HasA binding both in vivo and in vitro.

An in vitro self-organized three-dimensional model of the blood-brain barrier microvasculature

2020 ◽  
Vol 16 (1) ◽  
pp. 015006 ◽  
Author(s):  
Figarol Agathe ◽  
Naka Yasuhiro ◽  
Shigemoto-Mogami Yukari ◽  
Furihata Tomomi ◽  
Sato Kaoru ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Three Dimensional ◽  
Brain Barrier ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Self Organized ◽  
Blood Brain

scholarly journals The Organotypic Multicellular Spheroid Is a Relevant Three-Dimensional Model to Study Adenovirus Replication and Penetration in Human Tumors in Vitro

2002 ◽  
Vol 6 (5) ◽  
pp. 609-614 ◽  
Author(s):  
Jacques Grill ◽  
Martine L.M. Lamfers ◽  
Victor W. van Beusechem ◽  
Clemens M. Dirven ◽  
D.Shareen Pherai ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Human Tumors ◽  
Multicellular Spheroid ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Adenovirus Replication
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