scholarly journals Unraveling the mysteries of centriolar satellites: time to rewrite the textbooks about the centrosome/cilium complex

2020 ◽  
Vol 31 (9) ◽  
pp. 866-872 ◽  
Author(s):  
Ezgi Odabasi ◽  
Umut Batman ◽  
Elif Nur Firat-Karalar
Keyword(s):  
Mechanism Of Action ◽  
Loss Of Function ◽  
The Third ◽  
The Past ◽  
Wide Range ◽  
Compositional Diversity ◽  
The Way

Centriolar satellites are membraneless granules that localize and move around centrosomes and cilia. Once referred to as structures with no obvious function, research in the past decade has identified satellites as key regulators of a wide range of cellular and organismal processes. Importantly, these studies have revealed a substantial overlap between functions, proteomes, and disease links of satellites with centrosomes and cilia. Therefore, satellites are now accepted as the “third component” of the vertebrate centrosome/cilium complex, which profoundly changes the way we think about the assembly, maintenance, and remodeling of the complex at the cellular and organismal levels. In this perspective, we first provide an overview of the cellular and structural complexities of centriolar satellites. We then describe the progress in the identification of the satellite interactome, which have paved the way to a molecular understanding of their mechanism of action and assembly mechanisms. After exploring current insights into their functions as recently described by loss-of-function studies and comparative evolutionary approaches, we discuss major unanswered questions regarding their functional and compositional diversity and their functions outside centrosomes and cilia.

Univocality within Multivocality

2010 ◽  
Vol 2 (2) ◽  
pp. 46-62 ◽  
Author(s):  
Elie Podeh
Keyword(s):  
Jewish History ◽  
Linear Process ◽  
History Textbooks ◽  
The Other ◽  
Fourth Generation ◽  
Third Generation ◽  
Gradual Improvement ◽  
The Third ◽  
The Past ◽  
The Way

Previous research on the way in which the Arab-Israeli conflict and the image of the Arab have been presented in Jewish history and civics textbooks established that there have been three phases, each typified by its own distinctive textbooks. The shift from the first to the third generation of textbooks saw a gradual improvement in the way the Other has been described, with the elimination of many biases, distortions and omissions. This article explores whether new history textbooks, published from 2000 to 2010, have entrenched or reversed this trend. With the escalation of the Israeli-Palestinian conflict since the early 2000s, one might have expected that the past linear process of improvement would be reversed. However, textbooks written over the last decade do not substantially differ from those written in the 1990s, during the heyday of the peace process. The overall picture is, therefore, that the current textbooks do not constitute a fourth generation.

Memory and the Cityscape: The German Architectural Debate about Postmodernism

1999 ◽  
Vol 17 (3) ◽  
pp. 71-84 ◽  
Author(s):  
Kathleen James-Chakraborty
Keyword(s):  
Personal Experience ◽  
Third Reich ◽  
Nazi Regime ◽  
National Community ◽  
The Third ◽  
The Past ◽  
The Future ◽  
The Third Reich ◽  
The Way ◽  
At Home

Few tools of Nazi propaganda were as potent or as permanent asarchitecture. At the instigation of Hitler, who had once aspired to bean architect, the Nazi regime placed unusual importance on thedesign of environments—whether cities, buildings, parade grounds, orhighways—that would glorify the Third Reich and express its dynamicrelationship to both the past and the future. Architecture and urbandesign were integral to the way the regime presented itself at homeand abroad. Newsreels supplemented direct personal experience ofmonumental buildings. Designed to last a thousand years, these edificesappeared to offer concrete testimony of the regime’s enduringcharacter. A more subtle integration of modern functions and vernacularforms, especially in suburban housing, suggested that technologicalprogress could coexist with an “organic” national communityrooted in a quasi-sacred understanding of the landscape.

The News Media

2017 ◽  
Author(s):  
C.W. Anderson ◽  
Leonard Downie ◽  
Michael Schudson
Keyword(s):  
News Media ◽  
New Technologies ◽  
Citizen Journalism ◽  
Social Rules ◽  
Non Profit ◽  
The Past ◽  
Private Interests ◽  
Wide Range ◽  
Advocacy Journalism ◽  
The Way

The business of journalism has an extensive, storied, and often romanticized history. Newspaper reporting has long shaped the way that we see the world, played key roles in exposing scandals, and has even been alleged to influence international policy. The past several years have seen the newspaper industry in a state of crisis, with Twitter and Facebook ushering in the rise of citizen journalism and a deprofessionalization of the industry, plummeting readership and revenue, and municipal and regional papers shuttering or being absorbed into corporate behemoths. Now billionaires, most with no journalism experience but lots of power and strong views, are stepping in to purchase newspapers, both large and small. This addition to the What Everyone Needs to Know® series looks at the past, present and future of journalism, considering how the development of the industry has shaped the present and how we can expect the future to roll out. It addresses a wide range of questions, from whether objectivity was only a conceit of late twentieth century reporting, largely behind us now; how digital technology has disrupted journalism; whether newspapers are already dead to the role of non-profit journalism; the meaning of “transparency” in reporting; the way that private interests and governments have created their own advocacy journalism; whether social media is changing journalism; the new social rules of old media outlets; how franchised media is addressing the problem of disappearing local papers; and the rise of citizen journalism and hacker journalism. It will even look at the ways in which new technologies potentially threaten to replace journalists.

The Public Secret

2017 ◽  
Author(s):  
Robert Eaglestone
Keyword(s):  
Subjective Experience ◽  
Third Reich ◽  
The Public ◽  
The Third ◽  
The Past ◽  
The Holocaust ◽  
The Third Reich ◽  
The Way

The knowledge of the murder of the European Jews was a public secret in the Third Reich. What is a ‘public secret’? How does it shape or reshape a society? The answers to these questions are key to understanding the Holocaust and other genocides. However, the public secret is elusive because of its nature: when it is at its most powerful, it cannot be explicitly discussed; when it no longer holds such power, people deny their knowledge of it and complicity in its concealment. Both the ‘subjective experience’ of the public secret and its wider meaning are beyond the limits of the discipline of history and are better elucidated obliquely through a work of fiction: in this case Kazuo Ishiguro’s Never Let Me Go, a novel which reflects on the past in the way historians cannot. Significantly, the public secret and the consequences of complicity are important concepts for understanding the post-Holocaust world.

Noise, narration and nose-pegs: Adapting Shakespeare for radio

2021 ◽  
Vol 19 (1) ◽  
pp. 41-58
Author(s):  
Andrea Smith
Keyword(s):  
Good Deal ◽  
Director General ◽  
Past Century ◽  
The Past ◽  
Sound Effects ◽  
Wide Range ◽  
The Way

The BBC’s first director general, John Reith, believed the plays of Shakespeare were perfect for radio, with ‘little in the way of setting and scenery’ and relying chiefly on plot and acting. However, a closer look at the texts reveals that many require a good deal of adaptation to work in sound only. That has not stopped BBC radio producers creating hundreds of productions over the past century. Instead, it has spurred many of them on to greater creativity. Initially reliant on narration, producers began to devise a wide range of techniques to make Shakespeare comprehensible without visuals. These include specially devised sound effects, soundscapes and music, as well as distorting the actors’ voices in various ways, including using nose-pegs and the assistance of the Radiophonic Workshop. This article uses audio and written evidence to uncover those techniques and examines how successful they have been deemed to be.

scholarly journals Independent Publisher in the Networks of Translation

2007 ◽  
Vol 19 (1) ◽  
pp. 135-173 ◽  
Author(s):  
Hélène Buzelin
Keyword(s):  
Research Programme ◽  
The Third ◽  
The Past ◽  
Ethnographic Approach ◽  
First Case ◽  
Translation Rights ◽  
Book Selling ◽  
Publishing Houses ◽  
The Way

Abstract Over the past ten years, the publishing and book selling industries (in Canada and elsewhere) have undergone a process of hyper-concentration that seems to threaten the future of independent publishing. How might this changing environment reflect on the attitudes of independent publishers toward translation and on the way they handle translation projects? This is the question this article seeks to examine. It is based on the first case study of a research programme that consists in following, by use of an ethnographic approach, the production process of literary translations in three independent Montréal-based publishing houses: from negotiations over the acquisition of translation rights to the launch of the translation. The article is divided into three parts. The first explains the rationale, methodology and ethics underlying this research; the second part tells the story of the title under study in a way that highlights the range of actors involved in the production of this translation, their own constraints and concerns, as well as the way publishing, editorial and linguistic/stylistic decisions intertwine. Based on this particular case, the third part discusses some of the strategies a publisher and his collaborators may devise in order to produce literary translations in an independent but network-based, competitive way. Particular emphasis is placed on strategies of cooperation such as co-translation and co-edition publishing, as well as on the role played by literary agents in the allocation of translation rights.

Robert Jenson and the spirit of it all: or, you (sometimes) wonder where everything else went

2007 ◽  
Vol 60 (2) ◽  
pp. 161-179
Author(s):  
Paul Cumin
Keyword(s):  
The Third ◽  
The Past ◽  
The Way

Three aspects of Robert Jenson's theology are investigated and then related according to their common pneumatological implications. First Jenson's neo-Barthian doctrine of revelation is considered as it leads him to an immediate or near-immediate relation of the being and act of God. This puts particular tensions on how he maintains the ontological distinction between creator and creation. Second, the same tension is found repeated in the way Jenson rejects the notion of divine timelessness. In bringing the being of God into history, and time into the being of God, he eventually calls the Father, Son and Spirit the ‘past’, ‘present’ and ‘future’ of the triune life. These tensions are heightened even further in the third section. With his characteristic concept of ‘narrative causality’ Jenson attempts a constructive recovery of Hegelian categories by suggesting the ‘End’ – as brought about by the Spirit-‘Outcome’ of God – is that ‘sublation which is itself not sublated’. The article concludes without entering the specifically Hegelian controversy, rather with more simple questions about the doctrinal integrity of Jenson's eschatology.

The Fifth Scenario: Identity Expansion in Organizational Psychology

2010 ◽  
Vol 3 (3) ◽  
pp. 281-285
Author(s):  
David P. Costanza ◽  
Jaclyn M. Jensen
Keyword(s):  
Professional Identity ◽  
Organizational Psychology ◽  
Tipping Point ◽  
Potential Outcomes ◽  
Multiple Perspectives ◽  
The Past ◽  
Wide Range ◽  
History Of ◽  
The Way

Ryan and Ford (2010) have argued that organizational psychology is at a tipping point in terms of its distinctiveness from other fields. Although the four scenarios they propose for organizational psychology's future cover a wide range of potential outcomes, we propose that there is another, more expansive, more optimistic scenario for our field: our identity needs to continue to evolve, expand, and extend itself to accommodate the evolving and expanding nature of the modern organizations we study. We suggest that the way forward for organizational psychology is to continue what we have done in the past: integrate theories from multiple disciplines, adopt multiple perspectives to the questions we face, and embrace the ambiguity inherent in the organizations we study. This additional scenario, which we term identity expansion, follows both from the history of the field and from research on professional identity. Below, we argue that both historically and theoretically such a future for our professional identity makes the most sense. Furthermore, we believe that organizational psychologists are in an excellent position to both shape and benefit from this expansion in identity.

scholarly journals Identity of Ao-Naga and Sümi-Naga Women as Gleaned from Folklores

2018 ◽  
Vol 10 (3) ◽  
pp. 94
Author(s):  
Resenmenla Longchar ◽  
H. Salome Kinny
Keyword(s):  
Oral Tradition ◽  
Cultural Practices ◽  
Striking Feature ◽  
Traditional Beliefs ◽  
The Third ◽  
The Past ◽  
Construction Of Identity ◽  
The Village ◽  
The Way

The word identity has drawn a lot of attention to itself more so in the present age where everyone seems to be in a quest to establish their own identity. This quest for identity is not an alien concept to Naga society which comprises of sixteen officially recognized communities. These communities rely upon their own set of folklores to glean their past. Folklores are a strong medium through which most of the traditional beliefs and cultural practices are embodied. It is a reflection of the past through which the identity of the community can be gleaned. Folklores are not mere spinning of tales to glorify one’s own community, but are narratives of the communities who follow oral-tradition. This paper attempts to glean the identity of Ao-Naga and Sümi-Naga women through their respective folklores. Ao-Naga and Sümi-Naga are two strong communities residing in Nagaland. Both the communities have rich folklores falling into different genres. A striking feature of most folktales is the way details are presented- the name of the village, location and presence of evidence in the present times suggesting the validity of the events in the folktales. After the construction of identity is done, this paper will compare the identity of women of these two communities. Women of both these communities have come a long way from what they were in the past. As the third and final component of this paper, it will analyse whether women are still under grip of their past identity or whether they have moved away from it to build a new identity for themselves in the 21<sup>st</sup> Century. This paper will further examine the identity of women in the 21<sup>st</sup> Century in the light of their past as constructed from the folklores.

Spinoza, Leibniz or a World ‘less exquisitely organized’

2018 ◽  
pp. 220-264
Author(s):  
Anthony Cordingley
Keyword(s):  
Final Part ◽  
Symbolic Language ◽  
The Third ◽  
Wide Range ◽  
The Way

This chapter concludes the investigation by detailing the way that Beckett’s narrator/narrator weighs up a philosophy of imminence (Spinoza) against a philosophy of transcendence (Leibniz). A new reading of Beckett’s relationship to these preeminent Rationalists is sustained through an examination of the Comment c’est notebooks and Beckett’s “Philosophy Notes”, and other works, such as, Endgame. A deep affinity is discovered between Beckett’s work and Spinoza’s uncompromising attack on the Judeo-Christian transcendentalism and anthropomorphism, which complicates the interpretation of Beckett’s most Leibnizian passages in the third and final Part of How It Is, when Beckett’s “I” attempts unsuccessfully to give a Rationalist account of his own cosmology. The dialectic Beckett fashions between Spinoza Leibniz amplifies the wide range of philosophical concerns detailed over the preceding chapters of this book. His novel use of Leibniz’s mathematics, in particular the calculus of infinitesimals, is revealed as source of a number of philosophical images that interact with other philosophical tropes to interrogate the nature of reality and the divine, and the claim to represent with reason the relationships between each. Mathematics emerges, in Beckett’s text, as a symbolic language transformed into an original, poetic order that expresses the complex and often paradoxical aesthetic questions of authorship, character and textuality.

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