Following the Second World Congress of the International Trade UnionConfederation (ITUC) held from June 21 to 25, 2010in Vancouver, this articleexamines the changes undergone by international trade unionism in recent years.The increasing power of multinational corporations,as a result of globalization,has led to a transformation in international tradeunionism which has produced areorganization of its structures and the emergenceof new forms of action toensure the protection of workers’ rights worldwide.The key argument of thisarticle is that the evolution of the structures andpractices of international tradeunion organizations over the last two decades has been characterized by theimplementation of strategies aimed, on the one hand, at reinforcing trade unionunity and, on the other hand, at targeting multinational corporations. Lastly,although the transformation of international tradeunionism has given rise toimportant structural changes, international trade union organizations continue toface formidable challenges in their efforts to effectively contribute to theregulation of the global economy.