scholarly journals 07 Examination of Reliability and Validity of Index of Postural Stability for Patients with Neurological Diseases

2019 ◽  
Vol 48 (Supplement_4) ◽  
pp. iv1-iv2
Author(s):  
Hisashi Mochizuki

Abstract Purpose The purpose of this study was to examine the reliability and validity of the Index of Postural Stability for patients with neurological disease. Methods The Index of postural stability (IPS) is a logarithmic value of the ratio between the stability limit and the area of centre of pressure (COP) in standing position, and is based on a probabilistic idea. Subjects were 75 patients with neurological disease (mean age; 63±12 years, 47 with Parkinson's disease, 9 with multiple sclerosis, 8 with Parkinsonism and others 11). Balance ability of subjects were assessed using IPS, Berg balance scale (BBS), Timed Up and Go Test(TUG), Functional Reach Test(FR), and gait ability of subjects were assessed using Functional Gait Category(FAC). IPS was assessed twice at intervals of about 30 minutes. Reliability of IPS was examined using Intraclass correlation coefficient (ICC), Bland-Altman plot and minimal detectable change (MDC). Validity of IPS was examined using correlation coefficients with BBS, TUG, FRT, and FAC. Results IPS showed significant and moderate correlation with BBS (r = 0.54), FR (r = 0.36), TUG (r =-0.43). IPS and FAC showed strong correlation (rs= 0.64). ICC of 2 separate measurements was 0.96. From the results of Bland-Altman plot, IPS had no additional error or proportional error (95%CI:-0.048~0.034, r=-0.0088, p=0.94). The MDC of IPS was 0.34. Discussion Since IPS has high reproducibility and does not have additional errors or proportional errors, and is also significantly related to other evaluation indexes of balance ability, it is considered that IPS may be a useful evaluation index of balance ability for patients with neurological diseases.

Author(s):  
Aparajita Dasgupta ◽  
Foulisa Pyrbot ◽  
Bobby Paul ◽  
Soumit Roy ◽  
Pritam Ghosh ◽  
...  

Introduction: Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases. Thus, regular and accurate measurement of Blood Pressure (BP) is essential for its early diagnosis and follow-up. There is a surge in popularity of digital sphygmomanometer due to its convenience of use and functionality. In contrast, the traditional universally accepted sphygmomanometer is aneroid type, hence there arise a need for comparison of digital and universally accepted Aneroid Sphygmomanometer in terms of agreement and correlation. Aim: To evaluate the agreement and correlation between blood pressure measurement by digital and aneroid sphygmomanometer. Materials and Methods: The clinic based cross-sectional study was conducted in the Out Patient Department (OPD) of Urban Heath Centre, All India Institute of Hygiene and Public Health, Kolkata, West Bengal, India. Adults visiting the OPD on two chosen days of the week, between June 2019 to July 2019 were selected using systematic random sampling. A total of 400 participants were included. Agreement and correlation between BP measurements by digital and aneroid sphygmomanometer was analysed by Cohen’s Kappa, Bland Altman Plot along with sensitivity, specificity and predictive values using Microsoft Excel and Statistical Package for the Social Sciences (SPSS) version 16.0. the p-value <0.05 was considered significant for the statistical test in the analysis. Results: Cohen’s Kappa value (0.59) revealed these two tools had moderate agreement in diagnosing hypertension. Sensitivity and specificity of digital sphygmomanometer taking aneroid sphygmomanometer as gold standard is 86% and 83.1% respectively. The BP readings of these two-tools showed moderate correlation as Intraclass Correlation Coefficient (ICC) for Systolic BP (SBP) and Diastolic BP (DBP) were 0.804 and 0.624, respectively. Bland Altman plot showed gross disagreement of SBP findings and disagreement between DBP findings was also noted. Conclusion: Digital device was found to be less accurate in detecting hypertension. Therefore, more similar research work is solicited to verify the accuracy of the very easy to use, the Digital BP monitor.


2020 ◽  
Author(s):  
shuai fu ◽  
Min Yang ◽  
Si Xu ◽  
Sha Wu ◽  
Xiao Xiao ◽  
...  

Abstract Background We aimed to assess the performance of revised MDRD, CKD-EPI, BIS, FAS and XiangYa equation in Chinese adults Methods We collected blood biochemical data of 623 chinese adult hospitalised patients within 48 hours before they underwent 99m Tc-DTPA GFR measurement. We computed the bias (mGFR-eGFR), the precision (IQR) ,the accuray (P30)and root mean square error (RMSE) relative to mGFR of each equation to evaluate performance. The ROC curves, Kappa value of McNemar test, Bland-Altman plot and the Intraclass correlation coefficient (ICC) were used to evaluate diagnostic accuracy and concordance. Results Totally, the FAS combined Scr and cysC equation performed supreme accuracy(P30=57.5%, RMSE=19.26), the cysC-based equation performed superior to Scr-based equation. Detailed P30 of the CKD-EPI cysC , FAS cysC , MDRD, CKD-EPI Scr-cysC , CKD-EPI Scr , FAS Scr , XiangYa was 56.7%, 56.0%, 53.5%, 52.2%, 48.8%, 51.4%, 43.0%. The CKD-EPI cysC equation showed the lowest bias and the highest accuracy(bias=-2.23, P30=57.4%) in GFR<60ml/min/1.73m 2 , followed by the FASscr-cysC equation(bias=-6.89, P30=55.4%). The XiangYa equation perfomed best in GFR≥60ml/min/1.73m 2 while worst in GFR<60 ml/min/1.73m 2 with bias(-5.79 vs -19.05), IQR(18.21 vs 10.85), P30(86.2% vs 21.1%), RMSE(16.68 vs 21.34). The CKD-EPI cysC equation had the lowest bias and the best accuracy(bias=-2.23, P30=59.4%) in age ≥70 years adults, followed by the FAS Scr-cysC equation equivalented to BIS-2 Scr-cysC equation(bias -5.33 vs -4.90, P30=57.3%), while the XiangYa equation performed worstly (bias=-20.39, P30=26.6%). Best ROC AUC was gaven by the FAS Scr-cysC equation(0.951),so was it had the highest Kappa value(0.364). The lowest Bias showed in Bland-Altman plot was the CKD-EPI cysC equation(bias=7.46). The highest ICC value was gaven by the FAS Scr-cysC equation(0.921). Secondly, it was the XiangYa equation with the ICC of 0.912. Conclusions The FAS Scr-cysC equation is verified most suitable and simpler applied to Chinese population. The CKD-EPI cysC equation is appropriate used in moderately and severely injured GFR(CKD3-5stage) and Seniors over 70 years old. The XiangYa equation performed perfectly in slightly injured GFR (CKD1-2stage), while further verification of XiangYa equation in multiple region need to carried out especially in moderately and severely injured GFR and older adults.


2019 ◽  
Vol 48 (Supplement_4) ◽  
pp. iv18-iv27 ◽  
Author(s):  
Kitima Rongsawad ◽  
Laddawon Worawan ◽  
Karnsiree Jirarojprapa ◽  
Sararat Kaewkham ◽  
Sarawut Khattiwong

Abstract Introduction Static postural stability is the ability to maintain the posture with minimum sway. Increasing postural sway during standing in different sensory conditions is associated with aging due to decline in sensory and motor functions. Sway area measured by using sway meter is usually simple method for assessing postural stability in elderly subjects. Like many biological measurements, sway area has an intrinsic variability that affects their test-retest reliability and responsiveness of postural stability assessment. The minimal detectable change (MDC) is ability to detect smallest change beyond measurement error that reflects a reliable change. Therefore, the MDC value could provide information of clinical relevance on postural stability. The aims of this study were to determine test-retest reliability and MDC of sway area obtained from sway meter in elderly subjects. Methods Twelve healthy elderly subjects aged 60 years and above were participated in this study. The test and retest repeatability of postural sway measurements were performed twice with a 1-hour interval. For each subject was assess postural sway using Lord’s sway meter during standing on 4 sensory conditions for 30 seconds of each condition. The test-retest reliability of sway area was calculated using intraclass correlation coefficient. The MDC for each sway area was calculated to quantify clinical relevance. Results The test-retest reliability of sway area revealed good to excellent reliability ranged from 0.85 to 0.94. Standard error of measurement (SEM) and MDC ranged from 75 to 205 mm2 and 209 to 568 mm2, respectively. Discussion and Conclusion Our findings reveal that sway area in different sensory conditions could be used in assessment of postural stability in elderly subjects. SEM and MDC of sway area increased when subjects were asked to close their eyes and on foam surface. The sway meter is a reliable tool for assessing postural stability in clinical setting.


2018 ◽  
Vol 38 (02) ◽  
pp. 115-123
Author(s):  
Preeti Baghel ◽  
Shefali Walia ◽  
Majumi M Noohu

Background: Transfers are very important in functional activities of subjects with spinal cord injury (SCI). The transfer assessment instrument (TAI) was the first tool to standardize the assessment of transfer technique. Objective: The purpose of this study was to establish the reliability and validity of TAI 3.0 in people with SCI in early rehabilitation phase. Methods: Thirty subjects with acute traumatic SCI were recruited from a tertiary care center for SCI management. Four raters assessed the quality of transfer using TAI 3.0 and a fifth rater used global assessment of transfer scale (VAS). TAI 3.0’s intraclass correlation coefficient (ICC) for intrarater and interrater reliability, standard error of measurement (SEM), minimal detectable change (MDC), limits of agreement and concurrent validity was determined. Results: The intrarater ICC was 0.93 to 0.98 and interrater ICC was 0.99, indicating high levels of reliability. The SEMs among the raters for TAI 3.0 total was from 0.23 to 0.28. The MDC among the raters TAI 3.0 total was from 0.54 to 0.86. Correlation for different raters between the TAI 3.0 and VAS ranged between 0.88 and 0.90. Conclusion: TAI 3.0 is a reliable and valid tool to assess the transfer skill in individuals with SCI in early rehabilitation phase.


2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0003
Author(s):  
Kalpesh Shah ◽  
Kumar Kaushik Dash

Category: Radiology Introduction/Purpose: There is growing evidence suggesting that the alignment of the leg (hip-knee-ankle or HKA axis) should be considered when planning an ankle replacement and alignment of the hindfoot (tibio-calcaneal or TC axis) should be considered when planning a knee replacement. The alignment of the HKA axis is assessed from standard long-leg radiographs, while the hindfoot alignment requires special views like Saltzman’s or Coetzee’s or similar. However we have discovered that by making minor adjustments to the way a standard long-leg radiograph is taken, it is possible to measure both the HKA as well as the TC axis from the same radiograph. The aim of our study was to compare the hindfoot alignment between a Saltzman’s view and the modified long-leg view. Methods: Approval was obtained for a prospective observational study on 65 consecutive patients referred to our hospital for a knee replacement. Patients with multiple joint arthritis, previous lower-limb surgery, or limb length discrepancy requiring shoe- raise were excluded. All patients had a preoperative modified long-leg view as part of our routine for radiographic assessment of a knee replacement; as well as a Saltzman’s view which served as a standard for hindfoot alignment. The long-leg alignment was measured using the standard HKA (hip-knee-ankle) axis, and the alignment of the hindfoot (tibio-calcaneal angle) was measured using the method described by Van Dijk et all. A difference of 3 degrees between the two observations was agreed to be considered as significant. Results were recorded by two Surgeons independently and analysed using the Bland-Altman Plot. The Intraclass Correlation Coefficient was used for inter-observer variation. Results: 48 patients were eligible for the study. The hindfoot angle measured in the modified long-leg view (mean 9.29 degrees, SD 4.26 degrees) was similar to that in the Saltzman’s view (mean 8.99 degrees, SD 4.16 degrees). The Scatter Plot showed a linear distribution, with Spearmann Correlation Coefficient of 0.892. Bland Altman Plot showed the differences in the measurements residing within the agreed difference of 3 degrees. Intraclass Correlation Coefficient was 0.94 for the modified long-leg view and 0.87 for the Saltzman’s view, suggesting excellent interobserver agreement. Conclusion: Our study shows that the position of the hindfoot can be reliably measured from the modified long-leg view, and this removes the need for additional radiographs for hindfoot alignment. As the entire femur, tibia and the hindfoot is accessible in the same long-leg view, this creates a platform for further research in to the mechanical axis of the entire lower limb as opposed to the HKA axis, and the effects of malalignment of the lower extremity in patients undergoing knee or ankle replacements.


2020 ◽  
Vol 4 (3) ◽  
pp. 109-122
Author(s):  
Gabriela M. Stegmann ◽  
Shira Hahn ◽  
Julie Liss ◽  
Jeremy Shefner ◽  
Seward B. Rutkove ◽  
...  

<b><i>Introduction:</i></b> Changes in speech have the potential to provide important information on the diagnosis and progression of various neurological diseases. Many researchers have relied on open-source speech features to develop algorithms for measuring speech changes in clinical populations as they are convenient and easy to use. However, the repeatability of open-source features in the context of neurological diseases has not been studied. <b><i>Methods:</i></b> We used a longitudinal sample of healthy controls, individuals with amyotrophic lateral sclerosis, and individuals with suspected frontotemporal dementia, and we evaluated the repeatability of acoustic and language features separately on these 3 data sets. <b><i>Results:</i></b> Repeatability was evaluated using intraclass correlation (ICC) and the within-subjects coefficient of variation (WSCV). In 3 sets of tasks, the median ICC were between 0.02 and 0.55, and the median WSCV were between 29 and 79%. <b><i>Conclusion:</i></b> Our results demonstrate that the repeatability of speech features extracted using open-source tool kits is low. Researchers should exercise caution when developing digital health models with open-source speech features. We provide a detailed summary of feature-by-feature repeatability results (ICC, WSCV, SE of measurement, limits of agreement for WSCV, and minimal detectable change) in the online supplementary material so that researchers may incorporate repeatability information into the models they develop.


2019 ◽  
pp. 1357633X1989078 ◽  
Author(s):  
Jodie E Chapman ◽  
Dominique A Cadilhac ◽  
Betina Gardner ◽  
Jennie Ponsford ◽  
Ruchi Bhalla ◽  
...  

Introduction Videoconferencing may help address barriers associated with poor access to post-stroke cognitive screening. However, the equivalence of videoconference and face-to-face administrations of appropriate cognitive screening tools needs to be established. We compared face-to-face and videoconference administrations of the Montreal Cognitive Assessment (MoCA) in community-based survivors of stroke. We also evaluated whether participant characteristics (e.g. age) influenced equivalence. Methods We used a randomised crossover design (two-week interval). Participants were recruited through community advertising and use of a stroke-specific database. Both sessions were conducted by the same researcher in the same location. Videoconference sessions were conducted using Zoom. A repeated-measures t-test, intraclass correlation coefficient (ICC), Bland–Altman plot and multivariate regression modelling were used to establish equivalence. Results Forty-eight participants (26 men, Mage = 64.6 years, standard deviation ( SD) = 10.1; Mtime since stroke = 5.2 years, SD = 4.0) completed the MoCA face-to-face and via videoconference on average 15.8 ( SD = 9.7) days apart. Participants did not perform systematically better in a particular condition, and no participant variable predicted difference in MoCA performance. However, the ICC was low (0.615), and the Bland–Altman plot indicated wide limits of agreement, indicating variability between sessions. Discussion Our findings provide preliminary evidence to support the use of videoconference to administer the MoCA following stroke. However, further research into the test–retest reliability of scores derived from the MoCA is needed in this population. Administering the MoCA via videoconference holds potential to ensure that all stroke survivors undergo cognitive screening, in line with recommended clinical practice.


2017 ◽  
Vol 52 (9) ◽  
pp. 809-819 ◽  
Author(s):  
Jaqueline Martins ◽  
Janaina Rodrigues da Silva ◽  
Marcelo Rodrigues Barbosa da Silva; ◽  
Débora Bevilaqua-Grossi

Context:  The belt-stabilized handheld dynamometer (HHD) has been used to assess the strength of knee- and hip-muscle groups. However, few researchers have examined its reliability and validity for assessing the strength of these muscles. Objective:  To evaluate the intra-examiner reliability of the belt-stabilized HHD and its validity and agreement with the isokinetic dynamometer for assessing the strength of knee- and hip-muscle groups. Design:  Cross-sectional study. Setting:  University laboratory. Patients or Other Participants:  We evaluated 26 healthy participants (13 men, 13 women; age = 23.5 ± 2.8 years, height = 1.7 ± 0.1 m, mass = 68.6 ± 12.4 kg) in 2 sessions using the belt-stabilized HHD and an isokinetic dynamometer for maximum strength of the hip adductors, abductors, flexors, extensors, internal rotators, and external rotators and the knee flexors and extensors. Main Outcome Measure(s):  We used reliability values provided by the intraclass correlation coefficient (2,3), standard error of measurement (SEM and percentage SEM), and minimal detectable change; correlation values comparing the belt-stabilized HHD and the isokinetic instrument using the Pearson correlation coefficient (r); and the mean difference in values comparing the 2 instruments using the Bland-Altman method. Results:  The intrarater HHD reliability was excellent for most measurements (range = 0.80–0.96; SEM = 1.3–5.3 kilograms of force or 4.8−18.9 Nm, percentage SEM = 7.0%–22.0%, minimal detectable change = 3.6–18.8 kilograms of force or 13.2−52.4 Nm) and was moderate only for bilateral knee flexion and left hip internal rotation (intraclass correlation coefficient [2,3] = 0.62–0.66 and 0.70, respectively). Correlation with the isokinetic dynamometer was moderate to high (r = 0.60–0.90), but the absolute values did not demonstrate concordance between results using the Bland-Altman method. Conclusions:  The belt-stabilized HHD measurements were reliable, and although they did not agree with those from the isokinetic dynamometer, the values were correlated for the hip- and knee-muscle groups.


Author(s):  
José Pino-Ortega ◽  
Markel Rico-González ◽  
Petrus Gantois ◽  
Fabio Y Nakamura

Heart rate variability (HRV) is becoming one of the most commonly used tools for tracking the time course of training adaptation/maladaptation of athletes and setting optimal training loads, leading to improved performance. The aim of this study was to compare Realtrack Systems manufacturer software (sPRO) with the Kubios HRV Standard. R-R intervals were recorded from 48 athletes using a chest strap synchronized to WIMU PRO™ device for 10 min to analyze time-domain HRV indices, located between the scapulae. Time-domain HRV indices analyzed included the square root of the mean squared differences of successive R-R intervals (RMSSD), standard deviation of normal R-R intervals (SDNN), and percentage of adjacent R-R intervals that differ from each other by more than 50 ms (pNN50). The intraclass correlation test and Bland-Altman plot were used to verify the agreement between the sPRO and the Kubios HRV Standard software for examining time-domain HRV indices. The intraclass correlation coefficient showed high values of agreement of R-R intervals and time-domain HRV indices between the two software options (RMSSD, SDNN, and pNN50; ICC > 0.951). The Bland-Altman plot showed low bias for all the HRV indices analyzed (bias = −0.11 to −1.08). In addition, no systematic bias was found between the residual of the mean difference and the average values of the two software packages ( p > 0.05). Therefore, both software options can be used interchangeably for analyzing time-domain HRV records.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Guihua Xu ◽  
Yijun Hu ◽  
Shanqing Zhu ◽  
Yunxiang Guo ◽  
Lu Xiong ◽  
...  

AbstractIt is essential to know the normal range of the interocular symmetry of the cornea (ISC) for keratoconus diagnosis and corneal substitutes design. In the present study we investigated the interocular symmetry of corneal biometrics in 6,644 Chinese myopic patients from multiple ophthalmic centers. Corneal biometrics of both eyes were exported from the Pentacam instrument. Interocular symmetry of the corneal biometrics was analyzed by Spearman’s correlation test, intraclass correlation coefficient (ICC) analysis and Bland–Altman plot. Significantly strong interocular correlations were found in anterior and posterior corneal curvatures, corneal diameter, corneal thickness, corneal volume, corneal eccentricity, and corneal asphericity (r = 0.87–0.98, all P < 0.001). Moderate interocular correlations were observed in whole corneal astigmatism (r = 0.78) and posterior corneal astigmatism (r = 0.73). ICC between the right and left eyes was 0.94–0.98 for anterior and posterior corneal curvatures, corneal diameter, corneal thickness and corneal volume, 0.80–0.88 for corneal eccentricity and asphericity, and 0.73–0.79 for corneal astigmatism (all P < 0.001). Bland–Altman plot showed that the 95% limit of agreement between both eyes was narrow and symmetric in most of the corneal biometrics, suggesting strong interocular agreements in these corneal biometrics. In conclusion, significant interocular symmetry of corneal biometrics is observed in Chinese myopia patients. Extra attention should be paid to patients with interocular corneal asymmetry.


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