scholarly journals Comparisons of Five Equations Used for Estimating the Glomerular Filtrations Rate in Chinese Adults

2020 ◽  
Author(s):  
shuai fu ◽  
Min Yang ◽  
Si Xu ◽  
Sha Wu ◽  
Xiao Xiao ◽  
...  

Abstract Background We aimed to assess the performance of revised MDRD, CKD-EPI, BIS, FAS and XiangYa equation in Chinese adults Methods We collected blood biochemical data of 623 chinese adult hospitalised patients within 48 hours before they underwent 99m Tc-DTPA GFR measurement. We computed the bias (mGFR-eGFR), the precision (IQR) ,the accuray (P30)and root mean square error (RMSE) relative to mGFR of each equation to evaluate performance. The ROC curves, Kappa value of McNemar test, Bland-Altman plot and the Intraclass correlation coefficient (ICC) were used to evaluate diagnostic accuracy and concordance. Results Totally, the FAS combined Scr and cysC equation performed supreme accuracy(P30=57.5%, RMSE=19.26), the cysC-based equation performed superior to Scr-based equation. Detailed P30 of the CKD-EPI cysC , FAS cysC , MDRD, CKD-EPI Scr-cysC , CKD-EPI Scr , FAS Scr , XiangYa was 56.7%, 56.0%, 53.5%, 52.2%, 48.8%, 51.4%, 43.0%. The CKD-EPI cysC equation showed the lowest bias and the highest accuracy(bias=-2.23, P30=57.4%) in GFR<60ml/min/1.73m 2 , followed by the FASscr-cysC equation(bias=-6.89, P30=55.4%). The XiangYa equation perfomed best in GFR≥60ml/min/1.73m 2 while worst in GFR<60 ml/min/1.73m 2 with bias(-5.79 vs -19.05), IQR(18.21 vs 10.85), P30(86.2% vs 21.1%), RMSE(16.68 vs 21.34). The CKD-EPI cysC equation had the lowest bias and the best accuracy(bias=-2.23, P30=59.4%) in age ≥70 years adults, followed by the FAS Scr-cysC equation equivalented to BIS-2 Scr-cysC equation(bias -5.33 vs -4.90, P30=57.3%), while the XiangYa equation performed worstly (bias=-20.39, P30=26.6%). Best ROC AUC was gaven by the FAS Scr-cysC equation(0.951),so was it had the highest Kappa value(0.364). The lowest Bias showed in Bland-Altman plot was the CKD-EPI cysC equation(bias=7.46). The highest ICC value was gaven by the FAS Scr-cysC equation(0.921). Secondly, it was the XiangYa equation with the ICC of 0.912. Conclusions The FAS Scr-cysC equation is verified most suitable and simpler applied to Chinese population. The CKD-EPI cysC equation is appropriate used in moderately and severely injured GFR(CKD3-5stage) and Seniors over 70 years old. The XiangYa equation performed perfectly in slightly injured GFR (CKD1-2stage), while further verification of XiangYa equation in multiple region need to carried out especially in moderately and severely injured GFR and older adults.

Author(s):  
Aparajita Dasgupta ◽  
Foulisa Pyrbot ◽  
Bobby Paul ◽  
Soumit Roy ◽  
Pritam Ghosh ◽  
...  

Introduction: Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases. Thus, regular and accurate measurement of Blood Pressure (BP) is essential for its early diagnosis and follow-up. There is a surge in popularity of digital sphygmomanometer due to its convenience of use and functionality. In contrast, the traditional universally accepted sphygmomanometer is aneroid type, hence there arise a need for comparison of digital and universally accepted Aneroid Sphygmomanometer in terms of agreement and correlation. Aim: To evaluate the agreement and correlation between blood pressure measurement by digital and aneroid sphygmomanometer. Materials and Methods: The clinic based cross-sectional study was conducted in the Out Patient Department (OPD) of Urban Heath Centre, All India Institute of Hygiene and Public Health, Kolkata, West Bengal, India. Adults visiting the OPD on two chosen days of the week, between June 2019 to July 2019 were selected using systematic random sampling. A total of 400 participants were included. Agreement and correlation between BP measurements by digital and aneroid sphygmomanometer was analysed by Cohen’s Kappa, Bland Altman Plot along with sensitivity, specificity and predictive values using Microsoft Excel and Statistical Package for the Social Sciences (SPSS) version 16.0. the p-value <0.05 was considered significant for the statistical test in the analysis. Results: Cohen’s Kappa value (0.59) revealed these two tools had moderate agreement in diagnosing hypertension. Sensitivity and specificity of digital sphygmomanometer taking aneroid sphygmomanometer as gold standard is 86% and 83.1% respectively. The BP readings of these two-tools showed moderate correlation as Intraclass Correlation Coefficient (ICC) for Systolic BP (SBP) and Diastolic BP (DBP) were 0.804 and 0.624, respectively. Bland Altman plot showed gross disagreement of SBP findings and disagreement between DBP findings was also noted. Conclusion: Digital device was found to be less accurate in detecting hypertension. Therefore, more similar research work is solicited to verify the accuracy of the very easy to use, the Digital BP monitor.


2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0003
Author(s):  
Kalpesh Shah ◽  
Kumar Kaushik Dash

Category: Radiology Introduction/Purpose: There is growing evidence suggesting that the alignment of the leg (hip-knee-ankle or HKA axis) should be considered when planning an ankle replacement and alignment of the hindfoot (tibio-calcaneal or TC axis) should be considered when planning a knee replacement. The alignment of the HKA axis is assessed from standard long-leg radiographs, while the hindfoot alignment requires special views like Saltzman’s or Coetzee’s or similar. However we have discovered that by making minor adjustments to the way a standard long-leg radiograph is taken, it is possible to measure both the HKA as well as the TC axis from the same radiograph. The aim of our study was to compare the hindfoot alignment between a Saltzman’s view and the modified long-leg view. Methods: Approval was obtained for a prospective observational study on 65 consecutive patients referred to our hospital for a knee replacement. Patients with multiple joint arthritis, previous lower-limb surgery, or limb length discrepancy requiring shoe- raise were excluded. All patients had a preoperative modified long-leg view as part of our routine for radiographic assessment of a knee replacement; as well as a Saltzman’s view which served as a standard for hindfoot alignment. The long-leg alignment was measured using the standard HKA (hip-knee-ankle) axis, and the alignment of the hindfoot (tibio-calcaneal angle) was measured using the method described by Van Dijk et all. A difference of 3 degrees between the two observations was agreed to be considered as significant. Results were recorded by two Surgeons independently and analysed using the Bland-Altman Plot. The Intraclass Correlation Coefficient was used for inter-observer variation. Results: 48 patients were eligible for the study. The hindfoot angle measured in the modified long-leg view (mean 9.29 degrees, SD 4.26 degrees) was similar to that in the Saltzman’s view (mean 8.99 degrees, SD 4.16 degrees). The Scatter Plot showed a linear distribution, with Spearmann Correlation Coefficient of 0.892. Bland Altman Plot showed the differences in the measurements residing within the agreed difference of 3 degrees. Intraclass Correlation Coefficient was 0.94 for the modified long-leg view and 0.87 for the Saltzman’s view, suggesting excellent interobserver agreement. Conclusion: Our study shows that the position of the hindfoot can be reliably measured from the modified long-leg view, and this removes the need for additional radiographs for hindfoot alignment. As the entire femur, tibia and the hindfoot is accessible in the same long-leg view, this creates a platform for further research in to the mechanical axis of the entire lower limb as opposed to the HKA axis, and the effects of malalignment of the lower extremity in patients undergoing knee or ankle replacements.


2019 ◽  
Vol 48 (Supplement_4) ◽  
pp. iv1-iv2
Author(s):  
Hisashi Mochizuki

Abstract Purpose The purpose of this study was to examine the reliability and validity of the Index of Postural Stability for patients with neurological disease. Methods The Index of postural stability (IPS) is a logarithmic value of the ratio between the stability limit and the area of centre of pressure (COP) in standing position, and is based on a probabilistic idea. Subjects were 75 patients with neurological disease (mean age; 63±12 years, 47 with Parkinson's disease, 9 with multiple sclerosis, 8 with Parkinsonism and others 11). Balance ability of subjects were assessed using IPS, Berg balance scale (BBS), Timed Up and Go Test(TUG), Functional Reach Test(FR), and gait ability of subjects were assessed using Functional Gait Category(FAC). IPS was assessed twice at intervals of about 30 minutes. Reliability of IPS was examined using Intraclass correlation coefficient (ICC), Bland-Altman plot and minimal detectable change (MDC). Validity of IPS was examined using correlation coefficients with BBS, TUG, FRT, and FAC. Results IPS showed significant and moderate correlation with BBS (r = 0.54), FR (r = 0.36), TUG (r =-0.43). IPS and FAC showed strong correlation (rs= 0.64). ICC of 2 separate measurements was 0.96. From the results of Bland-Altman plot, IPS had no additional error or proportional error (95%CI:-0.048~0.034, r=-0.0088, p=0.94). The MDC of IPS was 0.34. Discussion Since IPS has high reproducibility and does not have additional errors or proportional errors, and is also significantly related to other evaluation indexes of balance ability, it is considered that IPS may be a useful evaluation index of balance ability for patients with neurological diseases.


BMC Nursing ◽  
2021 ◽  
Vol 20 (1) ◽  
Author(s):  
M. Gbareen ◽  
S. Barnoy ◽  
M. Theilla

Abstract Background Even though the nutritional assessment of chronically ill patients has a significant effect on outcomes, nurses’ time constraints in clinical encounters may make the process impractical. Also, cultural background has an effect on nutritional assessment. Patient nutritional self-assessment can ease some of the nurses’ workload. Objectives: To compare tools for subjective and objective nutritional assessment and to examine cultural differences in nutritional assessment between Jews and Arabs living in Israel. Methods The research design was cross-sectional; data were collected from Jews and Arabs with chronic illnesses living in the community during their visit to a public health clinic. The admitting nurse performed an objective nutritional assessment (Mini Nutritional Assessment (MNA)) after the patients completed the Subjective Nutritional Assessment (SANS). The data were analyzed using descriptive statistics, Pearson’s correlation coefficients were calculated to test the relationships between the variables, and independent student t-tests were used to compare the means and differences between groups. The diagnostic accuracy of the MNA and of the SANS was determined using the area under the curve (AUC) analysis of receiver operating characteristic (ROC) curves. The agreement between the MNA and SANS measurements was estimated by a Bland Altman plot. The level of significance employed throughout the analysis was 0.05. Results The sample was a convenience sample of 228 chronically ill patients, consisting of 121 Arabs and 107 Jews. A significant correlation was found between the subjective and objective nutritional assessments. The Bland–Altman plot demonstrated that the SANS and the MNA have a high level of agreement. Using the area under the curve (AUC) analysis of receiver operating characteristic (ROC) curves, showed an moderate diagnostic accuracy (73 % sensitivity and 30 % specificity). Conclusions Since the patient-completed nutritional assessment requires minimal time investment by nurses and we found a significant correlation and evidence for the accuracy and agreement of the objective and subjective assessments, further studies should assess and validate the possibility of replacing the objective nutritional assessment by the subjective assessment. Cultural background has a significant effect on patients’ nutritional self-assessment; hence, culture should be considered as part of the nutritional assessment.


2019 ◽  
pp. 1357633X1989078 ◽  
Author(s):  
Jodie E Chapman ◽  
Dominique A Cadilhac ◽  
Betina Gardner ◽  
Jennie Ponsford ◽  
Ruchi Bhalla ◽  
...  

Introduction Videoconferencing may help address barriers associated with poor access to post-stroke cognitive screening. However, the equivalence of videoconference and face-to-face administrations of appropriate cognitive screening tools needs to be established. We compared face-to-face and videoconference administrations of the Montreal Cognitive Assessment (MoCA) in community-based survivors of stroke. We also evaluated whether participant characteristics (e.g. age) influenced equivalence. Methods We used a randomised crossover design (two-week interval). Participants were recruited through community advertising and use of a stroke-specific database. Both sessions were conducted by the same researcher in the same location. Videoconference sessions were conducted using Zoom. A repeated-measures t-test, intraclass correlation coefficient (ICC), Bland–Altman plot and multivariate regression modelling were used to establish equivalence. Results Forty-eight participants (26 men, Mage = 64.6 years, standard deviation ( SD) = 10.1; Mtime since stroke = 5.2 years, SD = 4.0) completed the MoCA face-to-face and via videoconference on average 15.8 ( SD = 9.7) days apart. Participants did not perform systematically better in a particular condition, and no participant variable predicted difference in MoCA performance. However, the ICC was low (0.615), and the Bland–Altman plot indicated wide limits of agreement, indicating variability between sessions. Discussion Our findings provide preliminary evidence to support the use of videoconference to administer the MoCA following stroke. However, further research into the test–retest reliability of scores derived from the MoCA is needed in this population. Administering the MoCA via videoconference holds potential to ensure that all stroke survivors undergo cognitive screening, in line with recommended clinical practice.


Author(s):  
José Pino-Ortega ◽  
Markel Rico-González ◽  
Petrus Gantois ◽  
Fabio Y Nakamura

Heart rate variability (HRV) is becoming one of the most commonly used tools for tracking the time course of training adaptation/maladaptation of athletes and setting optimal training loads, leading to improved performance. The aim of this study was to compare Realtrack Systems manufacturer software (sPRO) with the Kubios HRV Standard. R-R intervals were recorded from 48 athletes using a chest strap synchronized to WIMU PRO™ device for 10 min to analyze time-domain HRV indices, located between the scapulae. Time-domain HRV indices analyzed included the square root of the mean squared differences of successive R-R intervals (RMSSD), standard deviation of normal R-R intervals (SDNN), and percentage of adjacent R-R intervals that differ from each other by more than 50 ms (pNN50). The intraclass correlation test and Bland-Altman plot were used to verify the agreement between the sPRO and the Kubios HRV Standard software for examining time-domain HRV indices. The intraclass correlation coefficient showed high values of agreement of R-R intervals and time-domain HRV indices between the two software options (RMSSD, SDNN, and pNN50; ICC > 0.951). The Bland-Altman plot showed low bias for all the HRV indices analyzed (bias = −0.11 to −1.08). In addition, no systematic bias was found between the residual of the mean difference and the average values of the two software packages ( p > 0.05). Therefore, both software options can be used interchangeably for analyzing time-domain HRV records.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Guihua Xu ◽  
Yijun Hu ◽  
Shanqing Zhu ◽  
Yunxiang Guo ◽  
Lu Xiong ◽  
...  

AbstractIt is essential to know the normal range of the interocular symmetry of the cornea (ISC) for keratoconus diagnosis and corneal substitutes design. In the present study we investigated the interocular symmetry of corneal biometrics in 6,644 Chinese myopic patients from multiple ophthalmic centers. Corneal biometrics of both eyes were exported from the Pentacam instrument. Interocular symmetry of the corneal biometrics was analyzed by Spearman’s correlation test, intraclass correlation coefficient (ICC) analysis and Bland–Altman plot. Significantly strong interocular correlations were found in anterior and posterior corneal curvatures, corneal diameter, corneal thickness, corneal volume, corneal eccentricity, and corneal asphericity (r = 0.87–0.98, all P < 0.001). Moderate interocular correlations were observed in whole corneal astigmatism (r = 0.78) and posterior corneal astigmatism (r = 0.73). ICC between the right and left eyes was 0.94–0.98 for anterior and posterior corneal curvatures, corneal diameter, corneal thickness and corneal volume, 0.80–0.88 for corneal eccentricity and asphericity, and 0.73–0.79 for corneal astigmatism (all P < 0.001). Bland–Altman plot showed that the 95% limit of agreement between both eyes was narrow and symmetric in most of the corneal biometrics, suggesting strong interocular agreements in these corneal biometrics. In conclusion, significant interocular symmetry of corneal biometrics is observed in Chinese myopia patients. Extra attention should be paid to patients with interocular corneal asymmetry.


2009 ◽  
Vol 12 (8) ◽  
pp. 1078-1084 ◽  
Author(s):  
Yuna He ◽  
Fengying Zhai ◽  
Guansheng Ma ◽  
Edith JM Feskens ◽  
Jian Zhang ◽  
...  

AbstractObjectiveTo assess the association of indicators of general and abdominal obesity with the prevalence of type 2 diabetes (T2DM) and intermediate hyperglycaemia (IHG) in the Chinese population.MethodsWe used data of 50 905 adults aged 18–79 years in the 2002 China National Nutrition and Health Survey. Recommended Chinese cut-off values were used for BMI (24 kg/m2) and waist circumference (WC; 85 cm in men, 80 cm in women). Optimal cut-offs for waist:height ratio (WHtR) were determined from analyses of receiver-operating characteristic (ROC) curves.ResultsThe prevalence of T2DM and IHG was 2·6 % and 1·9 % respectively. ROC curve analyses indicated 0·5 as the optimal cut-off value for WHtR in both sexes. High BMI, WC and WHtR were all associated with the prevalence of glucose tolerance abnormalities, with the highest prevalence ratio (PR) for high WHtR (men: PR = 2·85, 95 % CI 2·54, 3·21; women: PR = 3·10, 95 % CI 2·74, 3·51). When combining BMI and WHtR, in men either a high BMI or a high WHtR alone was associated with increased risk. Among women, a high BMI without a concomitant high WHtR was not associated with increased glucose tolerance abnormalities risk, whereas a high WHtR was associated with risk irrespective of BMI.ConclusionsAmong the Chinese adult population measures of central obesity are better predictors of glucose tolerance abnormalities prevalence than BMI. A WHtR cut-off point of 0·5 for both men and women can be considered as optimum for predicting (pre-) diabetes and may be a useful tool for screening and health education.


2012 ◽  
Vol 27 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Melanie Kleynen ◽  
Susy M Braun ◽  
Anna JHM Beurskens ◽  
Jeanine A Verbunt ◽  
Rob A de Bie ◽  
...  

Objective: Reinvestment is a phenomenon in which conscious control of movements that are best controlled automatically disrupts performance. The propensity for reinvestment may therefore play an important role in the movement rehabilitation process. The Movement-Specific Reinvestment Scale measures an individual’s propensity for reinvestment. The aim of this study was to translate the scale for use with Dutch participants with stroke and to assess its reliability. Design: A test–retest design. Setting: In community after discharge from rehabilitation centre. Subjects: Forty-five people with stroke. Measures: Reliability of the translated scale was assessed using intraclass correlation coefficients (ICC) and Bland–Altman plot. Results: The ICC was 0.85 (95% confidence interval (CI) 0.74–0.91). Limits of agreement ranged from −2.38 to 3.10. Conclusion: The Dutch Movement-Specific Reinvestment Scale appears to be a reliable tool with which to assess the propensity for movement-specific reinvestment by people with stroke.


2021 ◽  
Vol 34 ◽  
Author(s):  
Maria Luiza Freitas ANNES ◽  
Fernanda Beck TABAJARA ◽  
Rosane Dias da ROSA ◽  
Rita MATTIELLO ◽  
Ana Luisa Sant’Anna ALVES ◽  
...  

ABSTRACT Objective The aim of the study was to evaluate the agreement between the weight of older adults measured on a chair scale and a platform scale. Methods This is a cross-sectional study. We evaluated 131 older adults (?60 years old), walk-in patients, admitted to a university hospital. Weight was measured on a digital chair scale model MS5811 (Charder® brand) and after on a mechanical platform scale (Filizola® brand). For the agreement analysis, the intraclass correlation coefficient and the Bland-Altman plot were used. Results Most of the sample consisted of males individuals (57.3%; n= 75). The average age was 70.47±7.59 years (60-96 years old). Measured by both methods, weight showed normal distribution. The average weight measured was 67.99±14.03 kg on the chair scale and 68.04±14.02 kg on the platform scale. The intraclass correlation coefficient of weight measured by the two methods was 1.00 (IC95%=1.00-1.00; p<0.001). In the Bland-Altman plot, the mean bias for the weight measured on the chair scale and the platform scale was 0.049 (IC95%=-0.011 to 0.110; p=0.1084). Conclusions The agreement between the weight measured on a chair scale and on a platform scale was almost excellent. Thus, the chair scale can be used as an alternative method of measuring weight, especially in the older adults with postural instability, mobility restrictions or immobility syndrome.


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