scholarly journals Associations of maternal fructose and sugar-sweetened beverage and juice intake during lactation with infant neurodevelopmental outcomes at 24 months

2020 ◽  
Vol 112 (6) ◽  
pp. 1516-1522
Author(s):  
Paige K Berger ◽  
Jasmine F Plows ◽  
Roshonda B Jones ◽  
Tanya L Alderete ◽  
Claudia Rios ◽  
...  
Keyword(s):  
Cognitive Development ◽  
Breast Milk ◽  
Infant Development ◽  
Somatic Growth ◽  
Infant Cognition ◽  
Neurodevelopmental Outcomes ◽  
Sugar Sweetened Beverage ◽  
Prepregnancy Bmi ◽  
Sweetened Beverage ◽  
Infant Cognitive Development

ABSTRACT Background Our prior studies revealed that infant somatic growth is influenced by fructose in breast milk, and fructose in breast milk is increased in response to maternal sugar-sweetened beverage (SSB) intake in lactation. It is unknown whether infant neurodevelopmental outcomes are also influenced by maternal SSBs in lactation. Objectives To determine whether infant cognitive development at 24 postnatal months was influenced by maternal fructose consumption during lactation, and whether this relation persisted after accounting for maternal SSB and juice (SSB + J) intake. Methods Hispanic mother–infant pairs (n = 88) were recruited across the spectrum of prepregnancy BMI. Mothers completed two 24-h dietary recalls at 1 and 6 postnatal months, and reported breastfeedings per day. The Bayley-III Scales of Infant Development were administered at 24 postnatal months to assess infant cognition. Linear regressions were used to examine associations, reported as unstandardized (B) coefficients, 95% CIs, and P values. Results Mothers consumed 1656 ± 470 kcal, 21.8 ± 12 g fructose, and 2.5 ± 2.6 servings SSBs + J, and reported 6.9 ± 2.1 breastfeedings per day at 1 postnatal month. Controlling for maternal age, prepregnancy BMI, education level, kilocalories, infant age, sex, and birthweight revealed that infant cognitive development scores at 24 postnatal months correlated inversely with maternal fructose consumption at 1 postnatal month (B = −0.08; 95% CI = −0.13, −0.03; P < 0.01). The association of infant cognitive development scores with maternal fructose consumption was no longer significant after adjustment for maternal SSB + J intake (B = −0.05; 95% CI = −0.10, 0.00; P = 0.07), whereas maternal SSB + J intake was significant in the same model (B = −0.29; 95% CI = −0.52, −0.05; P = 0.02). Infant cognitive development scores were not associated with maternal fructose and SSB + J consumption at 6 postnatal months. Conclusions Our findings suggest that infant neurodevelopmental outcomes at 24 postnatal months can be adversely influenced by maternal fructose intake in early lactation, and this could be attributed to maternal SSB + J intake.

scholarly journals Maternal Consumption of Sugar-Sweetened Beverages and Juices in Lactation Predicts Poorer Infant Neurodevelopment at 24 Postnatal Months

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 943-943
Author(s):  
Paige Berger ◽  
Jasmine Plows ◽  
Roshonda Jones ◽  
Tanya Alderete ◽  
Claudia Rios ◽  
...  
Keyword(s):  
Breast Milk ◽  
Motor Development ◽  
Kidney Diseases ◽  
Maternal Diet ◽  
Total Sugar ◽  
Level Energy ◽  
Sugar Consumption ◽  
Neurodevelopmental Outcomes ◽  
Sugar Sweetened Beverage ◽  
Infant Neurodevelopment

Abstract Objectives Our prior studies have shown that maternal sugar-sweetened beverage and juice (SSBJ) consumption influenced breast milk fructose, and higher breast milk fructose was associated with greater infant growth. It is unknown whether maternal SSBJ consumption in lactation also influences infant neurodevelopment. The aim of this study was to determine whether maternal SSBJ consumption in lactation was associated with infant cognitive, language, and motor development at 24 postnatal months. Associations of maternal fructose, added, and total sugar consumption with infant neurodevelopmental outcomes were also examined. Methods Hispanic mother-infant pairs (N = 89) were recruited across the spectrum of pre-pregnancy BMI. Mothers completed two 24-hour dietary recalls at 1 and 6 postnatal months. The Bayley-III Scales were administered to all infants at 24 postnatal months to assess cognitive, language, and motor development. Multiple linear regressions were used to assess the correlations of maternal diet with infant Bayley-III outcomes, adjusting for maternal age, BMI, education level, energy intake, infant age, sex, and birthweight. Results At 1 postnatal month, mothers consumed 2.7 ± 3.1 servings SSBJ, 22 ± 12 g fructose, 59 ± 35 g added sugar, and 98 ± 47 g total sugar per day, and all were inversely associated with infant Bayley-III outcomes. Every 1 serving increase in SSBJs was associated with a 0.24 decrease in cognitive, 0.50 decrease in language, and 0.43 decrease in motor development scores (all P's ≤0.01). At 6 postnatal months, maternal SSBJ consumption remained inversely associated with infant motor development scores (B = −0.24, P = 0.03), but maternal fructose, added, and total sugar consumption were not associated with infant Bayley-III outcomes. Conclusions Our findings suggest that maternal SSBJ consumption in early lactation is an adverse influence of infant neurodevelopmental outcomes at 24 postnatal months. Funding Sources National Institute of Diabetes and Digestive and Kidney Diseases (NIH R01 DK110793); The Gerber Foundation (15PN-013).

scholarly journals How sugar-sweetened beverage tax revenues are being used in the United States

2021 ◽  
pp. 101388
Author(s):  
James Krieger ◽  
Kiran Magee ◽  
Tayler Hennings ◽  
John Schoof ◽  
Kristine A. Madsen
Keyword(s):  
United States ◽  
The United States ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Tax Revenues

scholarly journals Barriers to, and facilitators of, the adoption of a sugar sweetened beverage tax to prevent non-communicable diseases in Namibia: a policy landscape analysis

2021 ◽  
Vol 14 (1) ◽  
pp. 1903213
Author(s):  
Hans Justus Amukugo ◽  
Safura Abdool Karim ◽  
Anne Marie Thow ◽  
Agnes Erzse ◽  
Petronell Kruger ◽  
...  
Keyword(s):  
Communicable Diseases ◽  
Landscape Analysis ◽  
Non Communicable Diseases ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage

scholarly journals Infant Gut Microbiota Associated with Fine Motor Skills

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1673
Author(s):  
Inmaculada Acuña ◽  
Tomás Cerdó ◽  
Alicia Ruiz ◽  
Francisco J. Torres-Espínola ◽  
Ana López-Moreno ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Infant Development ◽  
16S Rrna Gene Sequencing ◽  
Fine Motor ◽  
Rrna Gene ◽  
Neurodevelopmental Outcomes ◽  
Gut Colonization ◽  
Healthy Infants ◽  
Behavioural Characteristics ◽  
Rrna Gene Sequencing

BACKGROUND: During early life, dynamic gut colonization and brain development co-occur with potential cross-talk mechanisms affecting behaviour. METHODS: We used 16S rRNA gene sequencing to examine the associations between gut microbiota and neurodevelopmental outcomes assessed by the Bayley Scales of Infant Development III in 71 full-term healthy infants at 18 months of age. We hypothesized that children would differ in gut microbial diversity, enterotypes obtained by Dirichlet multinomial mixture analysis and specific taxa based on their behavioural characteristics. RESULTS: In children dichotomized by behavioural trait performance in above- and below-median groups, weighted Unifrac b-diversity exhibited significant differences in fine motor (FM) activity. Dirichlet multinomial mixture modelling identified two enterotypes strongly associated with FM outcomes. When controlling for maternal pre-gestational BMI and breastfeeding for up to 3 months, the examination of signature taxa in FM groups showed that Turicibacter and Parabacteroides were highly abundant in the below-median FM group, while Collinsella, Coprococcus, Enterococcus, Fusobacterium, Holdemanella, Propionibacterium, Roseburia, Veillonella, an unassigned genus within Veillonellaceae and, interestingly, probiotic Bifidobacterium and Lactobacillus were more abundant in the above-median FM group. CONCLUSIONS: Our results suggest an association between enterotypes and specific genera with FM activity and may represent an opportunity for probiotic interventions relevant to treatment for motor disorders.

scholarly journals Residue Levels of Organochlorine Pesticides in Breast Milk and Its Associations with Cord Blood Thyroid Hormones and the Offspring’s Neurodevelopment

2019 ◽  
Vol 16 (8) ◽  
pp. 1438 ◽  
Author(s):  
Cheng-Chih Kao ◽  
Danielle E. Que ◽  
Sayre J. Bongo ◽  
Lemmuel L. Tayo ◽  
Yi-Hsien Lin ◽  
...  
Keyword(s):  
Breast Milk ◽  
Cord Blood ◽  
Negative Impact ◽  
Growth Hormones ◽  
Exposure Group ◽  
Linear Regression Models ◽  
Postnatal Exposure ◽  
Social Emotional ◽  
Neurodevelopmental Outcomes ◽  
Infant Neurodevelopment

Previous studies have demonstrated that organochlorine pesticide (OCP) exposure has a negative impact on the neurological function of infants. Only a few reports have investigated the thyroid and growth hormones and their relationship to neurodevelopment after human exposure to OCPs, especially in the case of infants. Our goal was to determine whether breastmilk OCP residues were associated with negative impacts and/or alterations in the neurodevelopment of infants among specific southern Taiwanese mother–breastfed infant pairs. Our subjects (n = 55 pairs) were recruited from southern Taiwan between 2007 and 2010. The thyroid and growth hormone levels in the cord blood samples collected after childbirth were determined. The breastmilk was gathered within one month after childbirth for the determination of OCP levels using a high-resolution gas chromatograph with mass spectrometry, and the neurodevelopment of 10–12-month-old infants was examined using the Bayley Scales of Infant and Toddler Development®, Third Edition (Bayley-III). It was observed that 4,4′-dichlorodiphenyl-dichloroethylene (4,4′-DDE) (mean = 10.3 ng/g lipid) was the most predominant OCP compound in the breastmilk samples. At higher concentrations (>75th percentile), specific OCPs were associated with significantly lower levels of thyroid and growth hormones than at lower concentrations (<75th percentile). Significantly higher odds ratios (ORs) were observed for binary cognitive (OR = 8.09, p = 0.025 for 4,4′-DDT), language (OR = 11.9, p = 0.013 for 4,4′-DDT) and social–emotional (OR = 6.06, p = 0.01 for trans-CHL) composite scores for specific OCPs belonging to the lower exposure group as compared to the higher OCP exposure group. The five domain Bayley-III infant neurodevelopment outcomes were negatively associated with specific OCPs in the breast milk samples based on the redundancy analysis (RDA) test. Bayley-III scales, which include cognitive, language, motor, social-emotional, and adaptive behavior scales, could be predicted by 4,4′-DDT, endrin, endosulfan I, heptachlor, or heptachlor epoxide using multivariate linear regression models with adjustment for maternal age, pre-pregnant BMI, parity, and infant gender. In conclusion, although our study showed that postnatal exposure to breast milk OCPs may be associated with infant neurodevelopmental outcomes and that prenatal exposure, if extrapolated from breastmilk levels, is associated with changes in thyroid and growth hormones that may have effects on neurodevelopment, these associations are only suggestive; thus, further studies are recommended for confirmation.

scholarly journals Sugar-Sweetened Beverage Consumption and Calcified Atherosclerotic Plaques in the Coronary Arteries: The NHLBI Family Heart Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1775
Author(s):  
Yash R. Patel ◽  
Tasnim F. Imran ◽  
R. Curtis Ellison ◽  
Steven C. Hunt ◽  
John Jeffrey Carr ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Coronary Arteries ◽  
Subclinical Atherosclerosis ◽  
Agatston Score ◽  
Sugar Sweetened Beverage ◽  
Cut Points ◽  
Sweetened Beverage ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Background: Sugar-sweetened beverage (SSB) intake is associated with higher risk of weight gain, diabetes, hypertension, cardiovascular disease, and cardiovascular mortality. However, the association of SSB with subclinical atherosclerosis in the general population is unknown. Objective: Our primary objective was to investigate the association between SSB intake and prevalence of atherosclerotic plaque in the coronary arteries in The National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Methods: We studied 1991 participants of the NHLBI Family Heart Study without known coronary heart disease. Intake of SSB was assessed through a semi-quantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac Computed Tomography (CT) and prevalent CAC was defined as an Agatston score ≥100. We used generalized estimating equations to calculate adjusted prevalence ratios of CAC. A sensitivity analysis was also performed at different ranges of cut points for CAC. Results: Mean age and body mass index (BMI) were 55.0 years and 29.5 kg/m2, respectively, and 60% were female. In analysis adjusted for age, sex, BMI, smoking, alcohol use, physical activity, energy intake, and field center, higher SSB consumption was not associated with higher prevalence of CAC [prevalence ratio (95% confidence interval) of: 1.0 (reference), 1.36 (0.70–2.63), 1.69 (0.93–3.09), 1.21 (0.69–2.12), 1.05 (0.60–1.84), and 1.58 (0.85–2.94) for SSB consumption of almost never, 1–3/month, 1/week, 2–6/week, 1/day, and ≥2/day, respectively (p for linear trend 0.32)]. In a sensitivity analysis, there was no evidence of association between SSB and prevalent CAC when different CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions: These data do not provide evidence for an association between SSB consumption and prevalent CAC in adult men and women.

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