An Unusual Presentation of Pleomorphic Lipoma

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S23-S24
Author(s):  
F Smith ◽  
E Martinez Duarte
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Tissue ◽  
Smooth Muscle Actin ◽  
Benign Tumors ◽  
Complete Excision ◽  
Pleomorphic Lipoma ◽  
Posterior Neck ◽  
Low Incidence ◽  
Mitotic Figures ◽  
The Right

Abstract Introduction/Objective Pleomorphic lipomas are benign tumors that typically occur in the shoulder, posterior neck, and back. Here, we present a case of a pleomorphic lipoma arising in an unusual location. Methods A 63-year-old male presented with a 1.3 x 1.3 x 0.9 cm enhancing slightly heterogeneous mass in the subcutaneous tissue superficial to the right parotid tail. The mass was biopsied and then excised. Results Histopathologic examination of the biopsy and resection specimens revealed an adipocytic neoplasm composed of mature adipose tissue with admixed spindle cells within a myxoid stroma. Lipoblasts, cellular atypia or increased mitotic figures were absent. Numerous floret-like cells were identified. These floret cells are characteristic of pleomorphic lipoma. The tumor cells were diffusely positive for CD34 and negative for desmin, smooth muscle actin, MyoD1, keratin, SOX10, and Melan-A by immunohistochemistry, consistent with pleomorphic lipoma. Conclusion Pleomorphic lipomas arising from the periparotid adipose tissue are rare. They tend to have a favorable prognosis with low incidence of recurrence if excised with clear margins. Following complete excision, the patient is doing well.

scholarly journals Diffuse neurofibroma - an uncommon cause of alopecia

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 166-169 ◽  
Author(s):  
Vasco Coelho Macias ◽  
Margarida Rafael ◽  
Cândida Fernandes ◽  
Joaninha Costa Rosa
Keyword(s):  
Young Adults ◽  
Subcutaneous Tissue ◽  
Neurofibromatosis Type ◽  
Benign Tumors ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
Children And Young Adults ◽  
Low Incidence ◽  
Infiltrative Tumor

Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and young adults. Histology generally shows an infiltrative tumor, composed of spindle cells in the dermis and subcutaneous tissue. Despite being rare, malignant transformation has been reported. The association between diffuse neurofibromas and neurofibromatosis type 1 still remains to be determined since some authors question the low incidence usually described. We report the case of a 42-year-old man who had a diffuse neurofibroma on the scalp presenting as alopecic plaques.

scholarly journals Rare Tumors Presenting as a Mastoid Mass

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Jiyeon Lee ◽  
Kyujin Han ◽  
Chang-Hee Kim
Keyword(s):  
General Practice ◽  
Chief Complaint ◽  
Sternocleidomastoid Muscle ◽  
Mass Lesion ◽  
Benign Tumors ◽  
Complete Excision ◽  
Palpable Mass ◽  
Rare Tumors ◽  
Intramuscular Lipoma ◽  
The Right

In terms of diagnosis, a painless isolated mass lesion around the mastoid area is rarely encountered in general practice. In the present study, we report two cases of painless benign mastoid tumors located in the postauricular region. The first patient visited our department with a painless progressing mass lesion behind the right ear, which was later revealed as an intramuscular lipoma in the mastoid origin site of the sternocleidomastoid muscle. The second patient similarly presented to our department with a chief complaint of a painless, palpable mass in the mastoid region. Biopsy results confirmed the diagnosis of an osteoma. In both cases, the tumor was surgically removed by a postauricular approach. Although osteoma and lipoma are benign tumors rarely involved in the mastoid area, presenting without symptoms, it is recommended of complete excision, especially in cases with symptoms or cosmetic deformity.

scholarly journals Cutaneous Angiomyolipoma (Angiolipoleiomyoma): Case Report and Review of Literature with Emphasis on Nomenclature

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S45-S45
Author(s):  
R Brudnik ◽  
M S Shurbaji ◽  
R E Vellila
Keyword(s):  
Adipose Tissue ◽  
Case Report ◽  
Ganglion Cyst ◽  
Smooth Muscle Actin ◽  
Smooth Muscles ◽  
Wrist Flexion ◽  
Male Predominance ◽  
Female Predominance ◽  
The Right

Abstract Introduction/Objective Cutaneous angiomyolipomas (AML) are rare lesions that have morphological similarities to renal AML, but appear to be biologically distinct. Methods/Case Report We report the case of a 69-year-old man who presented with a slowly enlarging nodule on the dorsum of the right hand that was painful upon wrist flexion and is slightly tender to palpation. A ganglion cyst was clinically suspected, and the lesion was excised. Microscopically, this was a well-circumscribed nodule with a thin fibrous capsule that was highlighted by a trichrome stain. The lesion was composed of thick-walled blood vessels surrounded by bundles of smooth muscles that intermingled with adipose tissue. Smooth muscle actin immunostain highlighted the smooth muscles, but HMB-45 was negative. There was no atypia, and no mitoses. A diagnosis of “cutaneous angiomyolipoma” was made. Results (if a Case Study enter NA) NA Conclusion A review of the limited number of published cases showed that unlike renal AML, this lesion is not associated with tuberous sclerosis, is negative for melanocytic markers, and shows male-predominance, suggesting that the two morphologically similar lesions are biologically unrelated. The 2018 WHO classification of skin Tumors does not list this entity, so nomenclature is not standardized. Some authors suggested that these are simply angioleiomyomas with prominent adipose tissue, but the female predominance of angioleiomyoma makes this unlikely. Others have recognized this as a distinct entity and described it as an “angiolipoleiomyoma”, to distinguish it from renal AML. We now advocate for the latter approach to avoid confusion with renal AML. Otherwise, the prefix of “cutaneous” should always be used in the diagnosis to highlight this distinction.

scholarly journals Chemodectoma in a Dog

2021 ◽  
Vol 49 ◽  
Author(s):  
Roseane Oliveira Feitosa ◽  
Saulo Romero Felix Gonçalves ◽  
Janilene De Oliveira Nascimento ◽  
Diana Guiomar Ferreira De Sena ◽  
Edna Michelly De Sá Santos ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Pericardial Effusion ◽  
Venous Return ◽  
Subcutaneous Tissue ◽  
Vena Cava ◽  
Small Animal ◽  
Benign Tumors ◽  
Normocytic Anemia ◽  
Cardiac Tumors ◽  
The Right

Background: The chemodectoma is a rare neoplasm that originates from chemoreceptors located mainly in the aortic body, and carotid body and sinus, and responsible for detecting variations in blood pH, oxygen pressure and carbon dioxide. Dogs of brachiocephalic breeds and aged between 7 and 15 years have greater propensity. A neoplasm involves infiltrative growth in the vessels at the heart base, which leads to Congestive Heart Failure (CHF). The definitive diagnosis is performed by histopathological and/or immunohistochemical examination. The aim was to report a case of chemiodectoma in a dog, showed the disease clinical characteristics.Case: A 13-year-old male undefined breed dog was examinated in the medical clinic of small animal of Veterinary Hospital, Federal Rural University of Pernambuco (UFRPE) with respiratory effort, hyporexia, and edema in face, cervical, ventral thorax and thoracic limbs, with thirty days evoluted. About physical examination, we observed cachexia, orthopneic position, cyanosis and edema with a positive Godet sign, as well as 8% dehydration degree. Thoracic auscultation presented mixed dyspnea and muffled heart sounds. Chest radiography detected an radiopacity increase in pulmonary section and metastatic neoplastic process associated with pleural and pericardial effusion. Fluid therapy with lactated ringer and posterior thoracentesis in the right hemithorax region was performed for greater respiratory comfort for the patient. Hematological count and biochemical profiles stated normochromic normocytic anemia, relative and absolute lymphopenia, thrombocytopenia, as well as increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The patient died after 12 hours when was submitted to necroscopic examination and histopathological evaluation. An infiltrative tumor of cardiac base was observed invading the light of the right atrium, obstructing the venous return, as well as a large thrombus located in the left ventricle and diffuse nodules in the lungs. Hydrothorax and hydroperitoneum were observed with serous fluid, with hepatic, renal and brain congestion, and duodenum hemorrhage. Histologically, the tumor was characterized as a chemodectoma with pulmonary metastasis.Discussion: Cardiac tumors are uncommon for canine population. A study sampled 729,265 dogs with observed incidence reaching 0.19%. The most common type is hemangiosarcoma with 69%, followed by chemiodectoma and lymphoma. Authors describe predisposed brachycephalic breeds such as Boxer, Boston Terrier and French Bulldog. In our case, the patient had elongated snout and undefined breed. Deregulation of chemoreceptors, which detect changes in pH and partial oxygen and carbon dioxide pressures, can result in hyperpnea and dyspnoea. Edema represents a deficit in venous return from the cranial and cervical regions, with consequent increase in hydrostatic pressure and liquid leakage into the thoracic cavity and subcutaneous tissue, thus inferring the Caudal Vena Cava Syndrome (CVCS). Tumors from the cardiac base, integrated with the large arteries insertion and adjacent to the atria, can cause pericardial effusion observed in this case. Chemodectomas are described as essentially benign tumors with low metastatic potential. In this case, pulmonary metastasis was detected. Surgical treatment is recommended when feasible. In this case, the patient had late veterinary care, in addition to the contraindication for surgery by the lung metastasis presence.

scholarly journals Intradiploic Epidermoid of the Tegmen Tympani With Cochlear Invasion

2020 ◽  
pp. 014556131990075
Author(s):  
Cheryl Yu ◽  
Aasif A. Kazi ◽  
Daniel H. Coelho
Keyword(s):  
Temporal Bone ◽  
Benign Tumors ◽  
Complex Signal ◽  
Complete Excision ◽  
Epidermoid Cysts ◽  
Tegmen Tympani ◽  
Prolonged Duration ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
Cyst Lining

Intradiploic epidermoid cysts are benign tumors that account for ∼1% of all intracranial space occupying lesions. Because of the indolent growth, symptoms are usually gradual in onset with a prolonged duration. While they can originate from any part of the skull, temporal bone epidermoids are rare. We describe a case of an unusual presentation of a temporal bone epidermoid cyst. A 64-year-old male presented with sudden right-sided hearing loss and worsening right eyelid ptosis was found to have a nonenhancing lobulated mass above the right tegmen tympani with complex signal and possible communication with the apical turn of the cochlea on magnetic resonance imaging (MRI). He underwent subtemporal craniotomy with excision of the cyst lining and matrix without any complications and was discharged home on postoperative day 1. Complete excision was not possible given that the facial nerve and cochlea were improved. He had subjective improvement in his hearing immediately after surgery. Intradiploic epidermoid cysts are benign tumors that can present anywhere in the skull with variable presentation. While complete excision is the goal, neurovascular involvement may make this challenging. The use of computed tomography scan and MRI can prove to be invaluable in determining accurate diagnosis and size for surgical planning.

Pleomorphic Leiomyosarcoma of the Adrenal Gland

2003 ◽  
Vol 127 (1) ◽  
pp. e32-e35
Author(s):  
Mario G. Lujan ◽  
Mai P. Hoang
Keyword(s):  
Adrenal Gland ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Neoplastic Cells ◽  
Ki 67 ◽  
Posterior Aspect ◽  
History Of ◽  
Mitotic Figures ◽  
The Right ◽  
Superior Pole

Abstract Primary leiomyosarcomas arising in the adrenal gland are exceedingly rare, with only 3 cases reported in the literature. We present the clinical, morphologic, and immunohistochemical features of a pleomorphic leiomyosarcoma, a variant of leiomyosarcoma that has not been described in the adrenal gland. A 63-year-old man presented with a 1-year history of enlarging right upper quadrant mass and pulmonary nodule. A diagnosis of metastatic pulmonary carcinoma to the adrenal gland was rendered on a needle biopsy specimen. Preoperative chemotherapy reduced only the pulmonary mass but not the adrenal mass, which continued to enlarge. Documented by computed tomography and confirmed at surgery, the tumor had completely replaced the right adrenal gland, invading into both the posterior aspect of the right liver and the superior pole of the right kidney. Histologic sections showed a diffuse proliferation of pleomorphic, large, and polygonal neoplastic cells with prominent nucleoli. Many bizarre mitotic figures were present. The neoplastic cells were strongly positive for desmin, calponin, and vimentin. Approximately 80% of the neoplastic cells were positive for the proliferation marker Ki-67. They were negative for smooth muscle actin, muscle-specific actin, myoglobin, myogenin, CD117, cytokeratins, carcinoembryonic antigen, epithelial membrane antigen, chromogranin, CD34, CD31, S100 protein, and HMB-45.

scholarly journals Phyllodes tumor of right breast with metastasis to lungs, rare presentation

2017 ◽  
Vol 4 (9) ◽  
pp. 3184
Author(s):  
Prabhat B. Nichkaode ◽  
Sachin Kumar Patel
Keyword(s):  
Spindle Cell ◽  
Phyllodes Tumor ◽  
Benign Tumors ◽  
Rare Presentation ◽  
Complete Excision ◽  
Cell Metastasis ◽  
Younger Age ◽  
Left Pleural Effusion ◽  
Simple Mastectomy ◽  
The Right

Incidence of Phylloids tumor of the breast is between 0.5% to 2% of all breast tumors. Most common age of occurrence is between 45-49 years but it can occur even at younger age. It is important to distinguish it from more benign tumors of the breast like fibroadenoma as far the management is concerned. Phylloids are fibroepethilial tumors with malignant potential, so needs complete excision. We present a case of 53 years female who underwent simple mastectomy for high grade Phylloids tumor in her right breast a year back, presented with breathlessness and local recurrence, proved to be metastatic Phylloids to lung causing left pleural effusion and nodule in the right upper lobe of lung. When the effusion was tapped it appeared to be pleomorphic spindle cell metastasis.

Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

2021 ◽  
pp. 106689692110219
Author(s):  
John L.S. Cunha ◽  
Marco A. Peñalonzo ◽  
Ciro D. Soares ◽  
Bruno A.B. de Andrade ◽  
Mário J. Romañach ◽  
...  
Keyword(s):  
English Language ◽  
Smooth Muscle Actin ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Carotid Bifurcation ◽  
Alpha Smooth Muscle Actin ◽  
S 100 ◽  
The Right ◽  
Adequate Management ◽  
Adipose Cells

Oncocytic lipoadenoma (OL) is a rare salivary gland tumor characterized by the presence of oncocytic cells and mature adipose tissue. To date, only 30 cases of OL have been reported in the English-language literature. We present 3 additional OL cases involving the parotid, including a synchronous presentation with paraganglioma of the right carotid bifurcation. Microscopically, both the OLs were composed of a mixed population of oncocytes and adipocytes in varying proportions surrounded by a thin, connective tissue fibrous capsule. Oncocytes were positive for pan-cytokeratins (CKs) AE1/AE3, epithelial membrane antigen, CK5, CK7, CK14, CK18, and CK19. Calponin, p63, alpha-smooth muscle actin, and carcinoembryonic antigen were negative. Vimentin and S-100 protein were positive only in adipose cells. Despite distinctive morphologic features, OL is often misdiagnosed, given its rarity. We hope to contribute to surgeons’ and pathologists’ awareness and knowledge regarding the existence of this tumor and provide adequate management through conservative surgical excision.

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