Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

2021 ◽  
pp. 106689692110219
Author(s):  
John L.S. Cunha ◽  
Marco A. Peñalonzo ◽  
Ciro D. Soares ◽  
Bruno A.B. de Andrade ◽  
Mário J. Romañach ◽  
...  
Keyword(s):  
English Language ◽  
Smooth Muscle Actin ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Carotid Bifurcation ◽  
Alpha Smooth Muscle Actin ◽  
S 100 ◽  
The Right ◽  
Adequate Management ◽  
Adipose Cells

Oncocytic lipoadenoma (OL) is a rare salivary gland tumor characterized by the presence of oncocytic cells and mature adipose tissue. To date, only 30 cases of OL have been reported in the English-language literature. We present 3 additional OL cases involving the parotid, including a synchronous presentation with paraganglioma of the right carotid bifurcation. Microscopically, both the OLs were composed of a mixed population of oncocytes and adipocytes in varying proportions surrounded by a thin, connective tissue fibrous capsule. Oncocytes were positive for pan-cytokeratins (CKs) AE1/AE3, epithelial membrane antigen, CK5, CK7, CK14, CK18, and CK19. Calponin, p63, alpha-smooth muscle actin, and carcinoembryonic antigen were negative. Vimentin and S-100 protein were positive only in adipose cells. Despite distinctive morphologic features, OL is often misdiagnosed, given its rarity. We hope to contribute to surgeons’ and pathologists’ awareness and knowledge regarding the existence of this tumor and provide adequate management through conservative surgical excision.

Phakomatous Choristoma of the Eyelid and Orbit: A Case Report

2019 ◽  
Vol 23 (4) ◽  
pp. 296-300
Author(s):  
Seyed Mohsen Rafizadeh ◽  
Hadi Ghadimi ◽  
Zohreh Nozarian
Keyword(s):  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Lower Eyelid ◽  
Medium Size ◽  
Positive Staining ◽  
Orbital Mass ◽  
Precise Diagnosis ◽  
S 100 ◽  
The Right ◽  
Histopathologic Findings

Phakomatous choristoma was first described as a distinct pathologic entity by Zimmerman in 1971. Report of only 26 cases of this tumor so far is an indicator of the rarity of phakomatous choristoma. We present a 4-month-old infant with an orbital mass beneath the right lower eyelid. Surgical excision was undertaken and the histopathologic findings of a dense fibrocollagenous stroma containing small to medium size islands and glandular-like structures surrounded by thick basement membrane and filled by amorphous eosinophilic material confirmed the diagnosis. Immunohistochemical study showed positive staining for S-100 and vimentin and negative staining for cytokeratins, glial fibrillary acidic protein, smooth muscle actin, synaptophysin, CD34, melan-A, and epithelial membrane antigen markers. This is the first patient with phakomatous choristoma presented from our country and the 27th reported case worldwide. Phakomatous choristoma is a rare, benign congenital tumor of lenticular anlage, almost always presenting in the medial lower eyelid and anterior orbit. Surgical excision is curative and allows precise diagnosis due to the unique histopathologic and immunostaining characteristics of this choristoma.

Myofibroma of the Gingiva: Report of a Case

2010 ◽  
Vol 34 (3) ◽  
pp. 253-257 ◽  
Author(s):  
Banu Özveri Koyuncu ◽  
Mert Zeytinoğlu ◽  
Taha Ünal ◽  
Bülent Zeytinoğlu
Keyword(s):  
Benign Tumor ◽  
Smooth Muscle Actin ◽  
Correct Diagnosis ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Solitary Lesion ◽  
Immunohistochemical Markers ◽  
Mesenchymal Neoplasm ◽  
S 100 ◽  
Histopathologic Evaluation

Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951. It occurs most commonly as a solitary lesion of soft tissue,skin, or bone in infancy. The prognosis of oral myofibromas is excellent, and surgical excision is curative. Recurrence is rare. Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy. This report describes a myofibroma of the gingiva in a 14 year old girl and is reported together with the conventional histologic, and immunohistochemical findings. The tumor showed rapid increase in size and clinical features suggestive of malignancy. However, on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers. The spindle cells were immunopositive for smooth muscle actin,and vimentin but were negative for desmin and S-100 protein. The patient was treated with surgical excision,and is followed-up for 33 months without any signs of recurrence.

scholarly journals A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review

2018 ◽  
Vol 12 ◽  
pp. 117955491881353
Author(s):  
Yanling Zhang ◽  
Heng Tang ◽  
Huaiyuan Hu ◽  
Xiang Yong
Keyword(s):  
Thyroid Gland ◽  
Tumor Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Frozen Sections ◽  
Ki 67 ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Painless Mass ◽  
The Right

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Frozen sections showed a spindle cell tumor of the thyroid gland. The nuclei of some of the tumor cells were obviously enlarged and deeply stained. Pseudocapsule invasion was observed in small foci. Samples showed neither mitosis nor necrosis and the nature of the tumor was difficult to determine. Paraffin sections showed a well-circumscribed nodular composed of intersecting fascicles of spindled to slightly epithelioid cells with eosinophilic cytoplasm and blunt-ended, cigar-shaped nuclei. We observed no significant nuclear atypia, mitotsis, or necrosis. Immunohistochemical staining showed the tumor cells to be positive for α-smooth muscle actin and h-caldesmon but negative for TG, TTF1, PAX8, S-100, CT, CK, and CD34. The ki-67 index was very low (<1%). Primary thyroid leiomyoma is rare and difficult to diagnose using frozen sections. Diagnosis requires immunohistochemical staining. Leiomyoma may be mistaken for other thyroid tumors also characterized by spindle cells.

scholarly journals Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Amerigo Giudice ◽  
Francesco Bennardo ◽  
Caterina Buffone ◽  
Ylenia Brancaccio ◽  
Francesca Maria Plutino ◽  
...  
Keyword(s):  
English Language ◽  
Immunohistochemical Analysis ◽  
Surgical Excision ◽  
Clinical Aspects ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Presumptive Diagnosis ◽  
Female Ratio ◽  
S 100 ◽  
Male To Female

Angioleiomyoma (AL) is an uncommon benign soft tissue neoplasia arising from the tunica media of the smooth muscle cells. AL appears as a solitary and slow-growing mass and seldom is observed in oral tissues. We reported a rare case of AL involving the cheek of a 17-year-old young woman. A review of the English-language literature was performed entering the keywords “angioleiomyoma” and “oral” in the search fields of PubMed. 70 results were identified. Excluded were cases that were not in the oral cavity or not compatible with the AL diagnosis or report lacking immunohistochemical analysis. According to the exclusion criteria, we selected 30 studies that included 63 cases of AL. The results of the review showed an average age of 42.97 years with a prevalence between the fourth and fifth decade of life with a male-to-female ratio of 1.95 : 1. The most affected sites were palate, buccal mucosa of the cheek, lip, tongue, and gingiva. Surgical excision was the treatment of choice, and diagnosis was possible through histopathological and immunohistochemical analysis. SMA, vimentin, CD34, desmin, and S-100 were the most common markers to guide the histopathological diagnosis of oral AL. In conclusion, oral AL is a rare entity, especially in adolescence as in the reported case of AL of the cheek in a 17-year-old woman. The clinical aspects of AL did not allow clinicians to make a correct presumptive diagnosis. A scrupulous histopathological analysis and immunohistochemical examinations are fundamental to differentiate AL from other lesions.

Glomus Tumor in the Digit of a Cat

2002 ◽  
Vol 39 (5) ◽  
pp. 590-592 ◽  
Author(s):  
K. Uchida ◽  
R. Yamaguchi ◽  
S. Tateyama
Keyword(s):  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Outer Side ◽  
Muscle Actin ◽  
Epithelioid Cells ◽  
Alpha Smooth Muscle Actin ◽  
The Third ◽  
Pathologic Features ◽  
S 100

A solitary mass approximately 1.5 X 2 cm located on the outer side of the third digit of the left forepaw of a 7-year-old male cross-breed cat was examined pathologically. The excised tumor mass was hard and white and located within the deep dermis and subcutis. Histopathologically, the mass consisted of a mixed population of small round epithelioid cells arranged in ribbon- or cordlike structures and spindle-shaped cells forming loose irregular bundles in a mucinous stroma. The epithelioid cells were often arranged around small blood vessels. Neoplastic cells were intensely positive for vimentin and alpha smooth muscle actin and negative for keratin, desmin, S-100 protein, and neuron-specific enolase. Based on these pathologic features, the tumor was diagnosed as a glomus tumor, a neoplasm not previously reported in cats and extremely rare in animals.

Orbital (Retrobulbar) Meningioma in a Simmental Cow

2007 ◽  
Vol 44 (4) ◽  
pp. 504-507 ◽  
Author(s):  
J. L. Reis ◽  
C. T. Kanamura ◽  
G. M. Machado ◽  
R. O. França ◽  
J. R. J. Borges ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Muscle Actin ◽  
Transmission Electron ◽  
S 100 ◽  
Poorly Differentiated ◽  
The Right ◽  
Mib 1

A 12-year-old Simmental cow was presented with a moderately firm irregular whitish mass of approximately 5 cm in diameter, occupying the right orbit. Microscopically, a poorly differentiated neoplasm was observed. The immunohistochemical panel included cytokeratins, vimentin, epithelial membrane antigen, Factor VIII, CD34, Mart-1, Melan A, smooth muscle actin, desmin, chromogranin, neuron-specific enolase, S-100 protein, and MIB-1. The neoplasm was negative for all of them, with the exception of vimentin and S-100 protein. Transmission electron microscopy revealed abundant desmosomes. These findings support the diagnosis of orbital (retrobulbar) meningioma.

scholarly journals Malignant Myoepithelioma with a Squamous Epithelial Component in the Mammary Gland of a Cynomolgus Monkey

2003 ◽  
Vol 31 (5) ◽  
pp. 549-553
Author(s):  
Xiuying Yang ◽  
Takao Hori ◽  
Ayako Fukuda ◽  
Yasuhiro Kamimura ◽  
Kimiaki Hirakawa ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Epithelial Cells ◽  
Cynomolgus Monkey ◽  
Smooth Muscle Actin ◽  
Distant Metastases ◽  
Solid Mass ◽  
Alpha Smooth Muscle Actin ◽  
Epithelial Component ◽  
S 100 ◽  
Cytokeratin 14

A solid mass arising from the mammary gland was found in a 7-year-old female cynomolgus monkey. Histologically, the mass consisted of 2 components: spindle-shaped or ovoid sarcomatous cells and squamous epithelial cells. Metastatic nodules noted in the lung, liver and the gallbladder had the same histological features as the mammary mass. Immunohistochemistry revealed that the sarcomatous cells were positive for alpha-smooth muscle actin ( α-SMA), vimentin, calponin, S-100 protein, epithelial membranous antigen (EMA), cytokeratin (large spectrum) and cytokeratin 14 (CK 14) in the cytoplasm, and p53, erbB-2 and progesterone receptor in the nuclei, but negative for desmin and estrogen receptor. The squamous epithelial cells were positive for EMA, cytokeratin (large spectrum) and CK 14, but negative for the rest. Both sarcomatous and squamous epithelial components were negative for glial fibrillary acidic protein (GFAP). Based on histological and immunohistochemical features, the present case was diagnosed as a malignant myoepithelioma with a squamous epithelial component in the mammary gland with distant metastases.

scholarly journals An Unusual Variant of a Common Palatal Salivary Gland Tumor: Case Report of a Pleomorphic Adenoma with Significant Lipomatous Metaplasia

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Sonal S. Shah ◽  
Tamer Zayed Moustafa
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Soft Palate ◽  
Clinical Presentation ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Gland Tumor ◽  
Complete Surgical Excision ◽  
Unusual Variant ◽  
The Right

Introduction. Salivary gland tumors are relatively common in the junction of the hard and soft palate area of the oral cavity. Pleomorphic adenoma is considered the most common benign salivary gland tumor in this location. Some of the rarer subtypes of this tumor may have a misleading clinical presentation. Recognition of these variants is important since long-standing pleomorphic adenomas have the potential to become malignant. Case Presentation. A healthy 24-year-old male was referred for a painless, large, slowly growing, exophytic swelling of the right hard and soft palate. Interestingly, the lesion was yellowish in color and soft to palpation, suggestive of an innocuous lipoma or cystic lesion. An incisional biopsy was performed and the diagnosis was consistent with pleomorphic adenoma with a significant adipose tissue component. The patient was referred to an oral surgeon and underwent a complete surgical excision. Upon two-year follow-up, the patient is doing well with no recurrences. Conclusion. This case highlights a rare microscopic variant of pleomorphic adenoma with altered clinical presentation that led to an erroneous clinical diagnosis. The importance of taking a biopsy for definitive diagnosis and appropriate management is reinforced.

Immunohistochemical detection of alpha-smooth muscle actin and S-100 in bovine mammary gland with mastitis

2019 ◽  
Author(s):  
Geeta Devi Leishangthem ◽  
Nittin Dev Singh ◽  
Amarjit Singh
Keyword(s):  
Smooth Muscle ◽  
Mammary Gland ◽  
Caspase 3 ◽  
Smooth Muscle Actin ◽  
Common Finding ◽  
Muscle Actin ◽  
Bovine Mammary Gland ◽  
Alveolar Cells ◽  
Alpha Smooth Muscle Actin ◽  
S 100

Fibrosis is a common finding in chronic mastitis. Epithelial-mesenchymal transition (EMT) plays a prominent role in fibrogenesis in adult tissues. The aim of this study was to investigate whether EMT occurs in bovine mastitis by assessing the expression or localization of alpha-smooth muscle actin (alpha-SMA), S-100 protein and caspase-3. Two normal bovine mammary gland tissue samples and five mastitic samples were used in the study. Antibodies to alpha-SMA, S-100 and caspase-3 were used for immunohistochemical studies. In mastitis there was increased expression of S-100 in the alveolar epithelial cells. Alpha-SMA was highly expressed in the areas where there is fibrosis in chronic mastitis. Further caspase-3 was observed in alveolar cells in mastitic tissue. Overexpression of S-100 and alpha-SMA directly correlates to the severity of mastitis.S-100 and alpha-SMA may serve as biomarkers to know the extent of tissue structural changes in mastitis. EMT could be one of the mechanistic pathways underlying the pathogenesis of fibrosis in mastitis.

CASE REPORT: ENDOMETRIAL STROMAL SARCOMA AND LIPOSARCOMA IN AN AFRICAN HEDGEHOG (Atelerix albiventris)

2016 ◽  
Vol 42 (03) ◽  
pp. 181-186 ◽  
Author(s):  
Fang-Yi Tsai ◽  
Hui-Ming Chang ◽  
Hao-Kai Chang ◽  
Ju-Pai Kao ◽  
Jiunn-Wang Liao
Keyword(s):  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Endometrial Stromal Sarcoma ◽  
Surgical Excision ◽  
Exploratory Laparotomy ◽  
Species Interaction ◽  
Neoplastic Cells ◽  
Stromal Sarcoma ◽  
Subcutaneous Mass ◽  
The Right

A 2-year-7-month-old female intact African hedgehog was presented with a subcutaneous mass around the right side of the neck as well as an intra-abdominal mass found during palpation. Surgical excision and exploratory laparotomy were performed. A uterine mass was identified during laparotomy and ovariohysterectomy was performed. The botryoid mass measured [Formula: see text][Formula: see text]cm and was located in the right uterine horn. It had a meat-like texture and was yellow-white and dark red in color. The removed subcutaneous mass measured [Formula: see text][Formula: see text]cm. The mass was well-encapsulated and had a yellow-white homogeneous texture on the cut surface. Histologically, the myometrium was invaded by neoplastic cells and the tissue boundaries were not obvious. Neoplastic cells were arranged in a whirling or intersecting pattern, with strong angiogenesis present. Vacuolated nuclei were round and oval to cigar shaped, with one to multiple nucleoli present. Immunohistochemistry revealed a positive reaction for CD10, but a negative reaction for smooth muscle actin (SMA) and desmin in the uterine neoplastic cells. Histologically, well-differentiated adipocytes with sheets of undifferentiated polygonal neoplastic cells, which were characterized by vacuolated nuclei with prominent multiple nucleoli, were found in the subcutaneous mass. Neoplastic cells of the subcutaneous mass were positively stained with antibodies of MDM2 and estrogen receptor (ER), but failed to give a positive result for vimentin because the cross-species interaction was insufficient. The definitive diagnosis was endometrial stromal sarcoma and liposarcoma in an African hedgehog.

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