Bilateral Cystic Neutrophilic Granulomatous Mastitis Due to Corynebacterium tuberculostearicum

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S47-S47 ◽  
Author(s):  
Alvaro Ibarra ◽  
Juan Donaire ◽  
Carolina Behnke ◽  
Alberto Salas ◽  
Camila Sanhueza
Keyword(s):  
Clinical Case ◽  
Granulomatous Inflammation ◽  
Left Breast ◽  
Etiological Agent ◽  
Imaging Features ◽  
Granulomatous Mastitis ◽  
Breast Volume ◽  
Gram Positive ◽  
Maldi Tof ◽  
Puerperal Mastitis

Abstract Introduction Cystic neutrophilic granulomatous mastitis (CNGM) is a form of breast lobulocentric granulomatous inflammation characterized by cystic spaces of dissolved lipid, surrounded by neutrophils. Corynebacterium is frequently the etiological agent, specially C kroppenstedtii. It is often painful and can simulate malignancy by clinical and imaging features. Clinical Case A 36-year-old woman, three pregnancies with puerperal mastitis in all. Consults by increase in left breast volume, painful, 1-month evolution, with erythema and not quantified fever. With antibiotherapy, erythema resolved, but the mass persisted. Ultrasound showed a 28-mm right nodule and extensive left architecture distortion, hypoechogenic, poorly delimited, which compromised superior quadrants, both BIRADS 4. Bilateral core biopsies had typical findings of CNGM, with bacteria inside cysts, identified with HE, which were Gram positive. The cultures gave Corynebacterium, typified as tuberculostearicum by MALDI-TOF methodology, with antibiotic multisensitivity. After 6 weeks of evolution, the last two with ciprofloxacin, on the left the mass had decreased, with 3-cm periareolar collection. Right lesion fistulized on the biopsy path. Conclusions We present a case of bilateral cystic neutrophilic granulomatous mastitis with clinical and imaging features suspected of malignancy. After 6 weeks of evolution, the last two with ciprofloxacin therapy, she had reduction of volume of the larger lesion and fistulization contralateral. She would probably require in its management, in addition to surgery to resolve the fistula, use of lipophilic antibiotics and corticosteroids.

Rapid species identification of seafood spoilage and pathogenic Gram-positive bacteria by MALDI-TOF mass fingerprinting

2011 ◽  
Vol 32 (21) ◽  
pp. 2951-2965 ◽  
Author(s):  
Karola Böhme ◽  
Inmaculada C. Fernández-No ◽  
Jorge Barros-Velázquez ◽  
Jose M. Gallardo ◽  
Benito Cañas ◽  
...  
Keyword(s):  
Species Identification ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Maldi Tof

scholarly journals Primary multiple BRCA associated breast cancer and ovarian cancer (clinical case)

2020 ◽  
pp. 248-257
Author(s):  
I. B. Kononenko ◽  
A. V. Snegovoy ◽  
Y. A. Bozhchenko ◽  
D. N. Kravchenko ◽  
Vladimir Yu. Selchuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Clinical Case ◽  
Brca2 Mutation ◽  
Cumulative Risk ◽  
Brca2 Gene ◽  
Left Breast ◽  
Luminal A ◽  
Uterine Tube ◽  
Luminal B

Introduction. The study of mutation in BRCA1/2 genes was first initiated in the USA and Europe, and later in Russia. Statistics indicate that women with the BRCA1/BRCA2 mutation have a higher risk of breast and/or ovarian cancer than the general population. According to different authors, the average cumulative risk among BRCA1 carriers is 65% (range 44–78%) for breast cancer and 39% (range 18–54%) for ovarian cancer. For mutation carriers in the BRCA2 gene, the risk for breast cancer is 45–49%, while the risk for RNA is 11–18%. However, in patients already diagnosed with breast cancer or ovarian cancer, the risk of a second tumor persists throughout life and may remain high even in old age. Treatment of BRCA-associated breast cancer and/or ovarian cancer is almost the same as treatment for sporadic cancer, and includes surgical, radiation, and drug anticancer therapy. However, there are some features that need to be considered in clinical practice. Clinical case. In this article we present the clinical experience of the treatment of a 32-year-old patient with BRCA1-associated primary multiple synchronous breast cancer and metachronous uterine tube cancer. In July 2015, the patient was diagnosed with synchronous cancer of both breast (Luminal A right breast cancer and Luminal B left breast cancer). As part of a treatment and with the patient’s consent, a bilateral adnexectomy was performed. In the histological examination of the operating material, the uterine tube cancer was diagnosed in situ. From 16.03.2016 to the present time the patient receives adjuvant endocrinotherapy without signs of disease progression. Conclusion. This clinical case study presents the importance of a combined approach to the treatment and prevention of BRCAassociated cancer.

scholarly journals Use of MALDI-TOF Mass Spectrometry for the Fast Identification of Gram-Positive Fish Pathogens

2017 ◽  
Vol 8 ◽  
Author(s):  
Gabriella B. N. Assis ◽  
Felipe L. Pereira ◽  
Alexandra U. Zegarra ◽  
Guilherme C. Tavares ◽  
Carlos A. Leal ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fish Pathogens ◽  
Gram Positive ◽  
Maldi Tof Mass Spectrometry ◽  
Fast Identification ◽  
Maldi Tof

Idiopathic granulomatous mastitis diagnosed during pregnancy associated with successful breastfeeding experience

2021 ◽  
Vol 14 (8) ◽  
pp. e241232
Author(s):  
Adeola M Awomolo ◽  
Adetola Louis-Jacques ◽  
Susan Crowe
Keyword(s):  
Needle Biopsy ◽  
Left Breast ◽  
First Year ◽  
Team Approach ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Core Needle ◽  
Multidisciplinary Team Approach ◽  
Breast Condition ◽  
Pregnancy And Lactation

Idiopathic granulomatous mastitis (IGM) is a rare benign breast condition with a course that is often rapidly progressive and slow to resolve. There is no consensus on management, especially during pregnancy and lactation. A 30-year-old at 33 weeks presented with mastalgia, induration and galactorrhoea in the left breast. There was no improvement with antibiotics. Initial workup was negative, and a core needle biopsy showed findings consistent with the diagnosis of IGM. She was treated with steroids antepartum. She was co-managed by rheumatology and her obstetrician/breastfeeding medicine specialist postpartum. She was treated with azathioprine, breastfed exclusively for 6 months and continued breastfeeding through the first year. A multidisciplinary team approach is crucial in diagnosing, treating, and facilitating successful breastfeeding in patients with IGM.

scholarly journals Bacterial Endocarditis Caused by Actinomyces oris: First Reported Case and Literature Review

2020 ◽  
Vol 8 ◽  
pp. 232470962091064
Author(s):  
Chanita Phichaphop ◽  
Nopporn Apiwattanakul ◽  
Suthep Wanitkun ◽  
Sophida Boonsathorn
Keyword(s):  
Infective Endocarditis ◽  
Cardiac Function ◽  
Bacterial Endocarditis ◽  
Gram Positive ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Flight Mass Spectrometry ◽  
Actinomyces Species ◽  
The Right ◽  
Tof Ms

Actinomyces species are gram-positive, facultative anaerobic bacilli. Infection caused by Actinomyces species is usually limited to cervicofacial, thoracic, and abdominopelvic regions. Infective endocarditis due to Actinomyces species is extremely rare with only 30 reported cases since 1939. We report a case of Actinomyces oris endocarditis in a 14-year-old boy who had a 2-week history of dyspnea on exertion without other constitutional signs. Transthoracic echocardiography was suggestive of perforation of the right coronary cusp of aortic valve. No organisms were isolated from blood cultures. The patient underwent surgical valve repair due to deteriorated cardiac function. Valve tissue culture did not initially identify the organism. However, the terminal subculture in a thioglycolate broth grew gram-positive bacilli. The matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) was compatible with Actinomyces oris. After 6 weeks of intravenous ampicillin, the patient remained well with improved cardiac function. We reviewed all reported cases of infective endocarditis caused by Actinomyces species, commenting on clinical characteristics and factors associated with unfavorable outcomes in infective endocarditis due to Actinomyces species. Although infective endocarditis caused by Actinomyces spp is rare, it could be considered in a case of culture-negative endocarditis since the clinical features might be indistinguishable from other bacterial endocarditis. Additionally, MALDI-TOF MS is a useful diagnostic tool for the identification of Actinomyces spp to improve the accuracy of diagnosis.

Identification of Gram-positive anaerobic cocci by MALDI-TOF mass spectrometry

2011 ◽  
Vol 34 (1) ◽  
pp. 58-62 ◽  
Author(s):  
A.C.M. Veloo ◽  
M. Erhard ◽  
M. Welker ◽  
G.W. Welling ◽  
J.E. Degener
Keyword(s):  
Mass Spectrometry ◽  
Gram Positive ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof

Rhodococcus equi granulomatous mastitis in an immunocompetent patient

2013 ◽  
Vol 62 (8) ◽  
pp. 1253-1255 ◽  
Author(s):  
Swapna R. Nath ◽  
Arun Peter Mathew ◽  
Arun Mohan ◽  
K. R. Anila
Keyword(s):  
Brain Heart Infusion ◽  
Immunocompetent Patient ◽  
Left Breast ◽  
Rhodococcus Equi ◽  
Cancer Tissue ◽  
Granulomatous Mastitis ◽  
Accurate Identification ◽  
Appropriate Treatment ◽  
Magnetic Resonance Imaging Mri ◽  
Solid Lesions

A 37-year-old immunocompetent woman was evaluated for progressive swelling of her left breast. Magnetic resonance imaging (MRI) showed multiple hypo-intense solid lesions and could not exclude breast cancer. Tissue biopsy was suggestive of granulomatous mastitis without any evidence of malignancy. Culture of the specimen in brain heart infusion broth grew Rhodococcus equi. The patient responded well to combination therapy with ciprofloxacin and azithromycin, and the lesions regressed in follow-up MRI. To the best of our knowledge, this is the first report of R. equi granulomatous mastitis. Accurate identification of this rare pathogen is necessary to provide appropriate treatment in granulomatous mastitis.

A Peculiar Form of Breast Fat Necrosis Simulating Hyaline Ring Granuloma (So-called Pulse Granuloma): A Rare Complication of Hyperparathyroidism

2017 ◽  
Vol 26 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Maria García-Martos ◽  
Angel Panizo-Santos
Keyword(s):  
Rare Complication ◽  
Degenerative Change ◽  
Malignant Lesion ◽  
Left Breast ◽  
Histopathological Study ◽  
Imaging Features ◽  
Fat Necrosis ◽  
Outer Quadrant ◽  
Peculiar Form ◽  
History Of

Pulse granuloma is a rare, foreign body inflammatory reaction that occurs mainly in the oral cavity. It is exceedingly rare elsewhere, with only isolated cases described in the literature. We report the case of a 79-year-old woman with a history of normocalcemic hyperparathyroidism who presented to our hospital with a painful 4-cm lump in the upper quadrants—upper outer quadrant of her left breast. The clinical and radiological (BIRADS-5) findings were indicative of a malignant lesion. However, core needle biopsy revealed features simulating hyaline ring granuloma (pulse granuloma-like). A definitive diagnosis of lipomembranous fat necrosis was made by identifying its characteristic histomorphology. Histopathological study is essential to establish an exact diagnosis since clinical and imaging features may mimic breast carcinoma. To our knowledge, this is the first reported case of a hyaline ring granuloma-like in the breast, which may represent a peculiar form of degenerative change of lipomembranous fat necrosis.

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