scholarly journals On the Relations Between Excess Fraction, Attributable Fraction, and Etiologic Fraction

2012 ◽  
Vol 175 (6) ◽  
pp. 567-575 ◽  
Author(s):  
Etsuji Suzuki ◽  
Eiji Yamamoto ◽  
Toshihide Tsuda
Author(s):  
Jeffrey R Donowitz ◽  
Jeannie Drew ◽  
Mami Taniuchi ◽  
James A Platts-Mills ◽  
Masud Alam ◽  
...  

Abstract Background Diarrheal pathogens have been associated with linear growth deficits. The effect of diarrheal pathogens on growth is likely due to inflammation which also adversely affects neurodevelopment. We hypothesized that diarrheagenic pathogens would be negatively associated with both growth and neurodevelopment. Methods We conducted a longitudinal birth cohort study of 250 children with diarrheal surveillance and measured pathogen burden in diarrheal samples using quantitative PCR. Pathogen attributable fraction estimates (AFe) of diarrhea over the first two years of life, corrected for socioeconomic variables, were used to predict both growth and scores on the Bayley III Scales of Infant and Toddler Development. Results 180 children were analyzed for growth and 162 for neurodevelopmental outcomes. Rotavirus, Campylobacter, and Shigella were the leading causes of diarrhea in year 1 while Shigella, Campylobacter, and ST-ETEC were the leading causes in year 2. Norovirus was the only pathogen associated with LAZ at 24 months and was positively associated (RC 0.42, CI 0.04, 0.80). Norovirus (RC 2.46, CI 0.05 – 4.87) was also positively associated with cognitive scores while sapovirus (RC -2.64, CI -4.80 – -0.48) and Typical EPEC (RC -4.14, CI -8.02 – -0.27) were inversely associated. No pathogens were associated with language or motor scores. Significant maternal, socioeconomic, and perinatal predictors were identified for both growth and neurodevelopment. Conclusion Maternal, prenatal, and socioeconomic factors were common predictors of growth and neurodevelopment. Only a limited number of diarrheal pathogens were associated with these outcomes.


2021 ◽  
Vol 3 ◽  
pp. 100062
Author(s):  
Ahmad Khosravi ◽  
Maryam Nazemipour ◽  
Tomohiro Shinozaki ◽  
Mohammad Ali Mansournia

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Gloria E. Anyalechi ◽  
Jaeyoung Hong ◽  
Robert D. Kirkcaldy ◽  
Harold C. Wiesenfeld ◽  
Paddy Horner ◽  
...  

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171200 ◽  
Author(s):  
Noah Kiwanuka ◽  
Ali Ssetaala ◽  
Ismail Ssekandi ◽  
Annet Nalutaaya ◽  
Paul Kato Kitandwe ◽  
...  

Water ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2232
Author(s):  
Ruohan Wu ◽  
Lingqian Xu ◽  
David A. Polya

Cardiovascular diseases (CVDs) have been recognized as the most serious non-carcinogenic detrimental health outcome arising from chronic exposure to arsenic. Drinking arsenic contaminated groundwaters is a critical and common exposure pathway for arsenic, notably in India and other countries in the circum-Himalayan region. Notwithstanding this, there has hitherto been a dearth of data on the likely impacts of this exposure on CVD in India. In this study, CVD mortality risks arising from drinking groundwater with high arsenic (>10 μg/L) in India and its constituent states, territories, and districts were quantified using the population-attributable fraction (PAF) approach. Using a novel pseudo-contouring approach, we estimate that between 58 and 64 million people are exposed to arsenic exceeding 10 μg/L in groundwater-derived drinking water in India. On an all-India basis, we estimate that 0.3–0.6% of CVD mortality is attributable to exposure to high arsenic groundwaters, corresponding to annual avoidable premature CVD-related deaths attributable to chronic exposure to groundwater arsenic in India of between around 6500 and 13,000. Based on the reported reduction in life of 12 to 28 years per death due to heart disease, we calculate value of statistical life (VSL) based annual costs to India of arsenic-attributable CVD mortality of between USD 750 million and USD 3400 million.


Author(s):  
V.Yu. Ivanov ◽  
E.I. Shubochkina ◽  
E.M. Ibragimova

Hygienic features of the employment of teenagers living in four regions of the Russian Federation (Moscow, St. Petersburg, Omsk and Pskov) have been studied. Regional peculiarities in the prevalence and structure of employment are established. It is confirmed that work in adolescence can have a negative impact on lifestyle and health. In the group of working adolescents, there is a higher prevalence of behavioral risk factors (smoking, drinking alcohol, drugs, lack of sleep, etc.). Adolescents with work experience have lower health indicators. The analysis of relative risk (RR) and etiologic fraction (EF) showed that the higher health risks are for adolescents who work continuously throughout the year.


2021 ◽  
Author(s):  
Liliana Cori ◽  
Massimo Cappai ◽  
Ivana Dettori ◽  
Natalina Loi ◽  
Pierpaolo Nurchis ◽  
...  

<p>INTRODUCTION</p><p>Following the recommendations of the National Prevention Plan, the Sardinia Region Department of Hygiene, Health and Social Security has promoted a programme dedicated to protecting the population from exposure to radon gas. The plan included: radon monitoring activities during a dedicated campaign based on geological mapping; radon Health Impact Assessment, HIA; drafting of “Guidelines for the construction/renovation of buildings”; community involvement and a radon risks communication campaign.</p><p>OBJECTIVES</p><p>To present the development of the HIA based on radon environment monitoring data and the communication process.</p><p>METHODS</p><p>Radon risk mapping combined the knowledge of geological composition of Sardinia Island and the results obtained by monitoring with dedicated devices.</p><p>HIA was implemented calculating cases attributable (CA) to radon exposure, combining the following parameters: Relative Risk (available by literature); mortality rate of lung cancer prevalence/incidence rate (baseline); exposed population size; radon concentration target.</p><p>The radon monitoring campaign required a widespread communication activity, while the results communication activity, based on a dedicated plan, involved multiple stakeholders.</p><p>RESULTS</p><p>On the basis of radon concentration data estimated by ARPAS, the HIA procedure estimated lung cancer deaths attributable to radon in areas of different exposure and throughout Sardinia. In the whole region, with an average concentration of 116 Bq/m3, radon-attributable cases were estimated at 143 out of 832 total expected deaths (attributable fraction 17.2%); in the area most at risk, including 49 municipalities, with an estimated average concentration of 202 Bq/m3, radon-attributable deaths were 13 out of 55 total (attributable fraction 23.6%).</p><p>The parameters of the algorithm and the results were presented and discussed with the local working groups.</p><p>A specific radon monitoring activity developed in schools helped to focus the efforts on the protection of school goers as vulnerable and susceptible groups. Urgent renovation and improvement activities in school and in other public administration buildings throughout the region were carried out.</p><p>Six guided discussions and four training sessions during six months were held to develop HIA and communication activities. A meeting to present the work was held in Nuoro town in October 2019, where information material was distributed and public attention raised around the issue.</p><p>The communication process aggregated several stakeholders including: civil servants in the field of health and the environment; public administrators; health professionals committed to spread knowledge about radon-free building.</p><p>CONCLUSIONS</p><p>The objectives of the regional program were focused to: - protect Sardinian population from radon risk, with special reference to vulnerable and susceptible subjects, particularly radon exposed smokers; - spread knowledge about risks; - inform about the opportunities to reduce risks.</p><p>Results indicate that the health of populations living in radon-exposed areas can be significantly improved by reducing exposure to radon and synergistic risk factors. It is essential to strengthen awareness-raising activities using historical and acquired knowledge and to monitor progress in order to reinforce further action, as these activities should be planned for the long term.</p>


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