scholarly journals Parvovirus B19 Infection in the First Trimester of Pregnancy and Risk of Fetal Loss: A Population-based Case-Control Study

2012 ◽  
Vol 176 (9) ◽  
pp. 803-807 ◽  
Author(s):  
J. Lassen ◽  
A. K. V. Jensen ◽  
P. Bager ◽  
C. B. Pedersen ◽  
I. Panum ◽  
...  
Keyword(s):  
Case Control Study ◽  
Parvovirus B19 ◽  
Fetal Loss ◽  
First Trimester ◽  
Population Based ◽  
Case Control ◽  
Parvovirus B19 Infection ◽  
First Trimester Of Pregnancy ◽  
Control Study

scholarly journals Serum placental growth factor in late first trimester of pregnancy for prediction of preeclampsia in primigravida - a case control study

2016 ◽  
Vol 6 (1) ◽  
pp. 106
Author(s):  
Rachna Agarwal ◽  
Shweta Chaudhary ◽  
Rajarshi Kar ◽  
Gita Radhakrishnan ◽  
Richa Sharma
Keyword(s):  
Case Control Study ◽  
Gestational Hypertension ◽  
Final Analysis ◽  
First Trimester ◽  
Case Control ◽  
Placental Growth Factor ◽  
Serum Samples ◽  
First Trimester Of Pregnancy ◽  
Nested Case Control ◽  
Control Study

Background: We studied the correlation of serum PLGF levels at 11-14 weeks in primigravida for prediction of future preeclampsia in a prospective nested case control study and estimated the critical levels of PLGF for possible use as screening test.Methods: Subjects with preeclampsia/gestational hypertension were taken as cases with an equal number of controls.Results: Out of 300 participants, final analysis was possible in 291 subjects. Thirty five were cases; two had early PE, 15 late PE and 18 had GH. PLGF level was lower in cases (20 pg/ml) compared to controls (79 pg/ml). PLGF was significantly lower in PE cases (15 pg/ml) compared to GH cases (34 pg/ml). PLGF had maximum area under the ROC curve (AUC) for PE with value of 0.867. Further, late PE had more AUC (0.853) as compared to GH (0.759). The cut off value for prediction of PE was found to be <30 pg/ml with 88.2% sensitivity and 71.4% specificity.Conclusions: PLGF levels were significantly lower in first trimester serum samples of subjects who later developed either preeclampsia or gestational hypertension. PLGF had better detection rate for PE and late PE as compared to GH.

A population-based case–control study of the association between weather-related extreme heat events and low birthweight

2020 ◽  
pp. 1-8
Author(s):  
Wayne R. Lawrence ◽  
Aida Soim ◽  
Wangjian Zhang ◽  
Ziqiang Lin ◽  
Yi Lu ◽  
...  
Keyword(s):  
Case Control Study ◽  
First Trimester ◽  
Population Based ◽  
Case Control ◽  
Extreme Heat ◽  
Maximum Temperature ◽  
Extreme Heat Events ◽  
The Impact ◽  
Heat Events ◽  
Control Study

Abstract Although prenatal exposure to high ambient temperatures were reported to be associated with preterm birth, limited research assessed the impact of weather-related extreme heat events (EHE) on birthweight, particularly by trimester. We, therefore, investigated the impact of prenatal EHE on birthweight among term babies (tLBW) by trimester and birthweight percentile. We conducted a population-based case–control study on singleton live births at 38–42 gestational weeks in New York State (NYS) by linking weather data with NYS birth certificates. A total of 22,615 cases were identified as birthweight <2500 gram, and a random sample of 139,168 normal birthweight controls was included. EHE was defined as three consecutive days with the maximum temperatures of ≥32.2 °C/90 °F (EHE90) and two consecutive days of temperatures ≥97th percentile (EHE97) based on the distribution of the maximum temperature for the season and region. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) with multivariable unconditional logistic regression, controlling for confounders. Overall exposure to EHE97 for 2 d was associated with tLBW (OR 1.05; 95% CI 1.02, 1.09); however, the strongest associations were only observed in the first trimester for both heat indicators, especially when exposure was ≥3 d (ORs ranged: 1.06–1.13). EHE in the first trimester was associated with significant reduction in mean birthweight from 26.78 gram (EHE90) to 36.25 gram (EHE97), which mainly affected the 40th and 60th birthweight percentiles. Findings revealed associations between multiple heat indicators and tLBW, where the impact was consistently strongest in the first trimester.

Maternal and foetal placental vascular malperfusion in pregnancies with anti-phospholipid antibodies

Rheumatology ◽  
2020 ◽  
Author(s):  
Arsenio Spinillo ◽  
Camilla Bellingeri ◽  
Chiara Cavagnoli ◽  
Irene De Maggio ◽  
Greta Riceputi ◽  
...  
Keyword(s):  
Case Control Study ◽  
Area Under The Curve ◽  
First Trimester ◽  
Case Control ◽  
Healthy Controls ◽  
Increased Risk ◽  
History Of ◽  
First Trimester Of Pregnancy ◽  
Penalized Logistic Regression ◽  
Control Study

Abstract Objective The objective of the study was to evaluate the rates of pathological placental lesions among pregnant subjects positive for aPL antibodies. Methods We performed a longitudinal case–control study including 27 subjects with primary APS, 51 with non-criteria APS, 24 with aPL antibodies associated with other well-known CTDs enrolled at the end of the first trimester of pregnancy and 107 healthy controls. Results Compared with controls and after correction for multiple comparisons, primary, non-criteria APS and aPL associated to CTD, subjects had lower placental weight, volume and area. After penalized logistic regression analysis to correct for potential confounders, placental lesions suggesting severe maternal vascular malperfusion (MVM) were more common among primary [odds ratio (OR) 11.7 (95% CI 1.3, 108)] and non-criteria APS [OR 8.5 (95% CI 1.6, 45.9)] compared with controls. The risk of foetal vascular malperfusion (FVM) was higher in primary APS [OR 4.5 (95% CI 1.2, 16.4)], aPL associated with CTDs [OR 3.1 (95% CI 1.5, 6.7)] and non-criteria APS [OR 5.9 (95% CI 1.7, 20.1)] compared with controls. Among clinical and laboratory criteria of APS, first trimester aCL IgG &gt;40 UI/ml [OR 4.4 (95% CI 1.3, 14.4)], LA positivity [OR 6.5 (95% CI 1.3, 33.3)] and a history of pre-eclampsia at &lt;34 weeks [OR 32.4 (95% CI 6.5, 161)] were the best independent first trimester predictors of severe MVM [area under the curve 0.74 (95% CI 0.6, 0.87)]. Conclusion Compared with healthy controls, pregnant subjects with aPL antibodies have an increased risk of placental lesions, suggesting MVM and FVM. First-trimester variables such as aCL IgG &gt;40 UI/ml and a history of pre-eclampsia were significant predictors of both severe MVM and FVM.

scholarly journals First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case–control study in Changsha, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wen Jiang ◽  
Wanqin Xie ◽  
Bin Ni ◽  
Haiyan Zhou ◽  
Zhiyu Liu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Cleft Palate ◽  
Air Pollutants ◽  
Cleft Lip ◽  
Case Control Study ◽  
First Trimester ◽  
Case Control ◽  
Orofacial Clefts ◽  
First Trimester Of Pregnancy ◽  
Control Study

Abstract Background A growing body of studies have investigated the association between air pollution exposure during early pregnancy and the risk of orofacial clefts, but these studies put more emphasis on particulate matter and reported inconsistent results, while research on the independent effects of gaseous air pollutants on orofacial clefts has been quite inadequate, especially in China. Methods A case–control study was conducted in Changsha, China from 2015 to 2018. A total of 446 cases and 4460 controls were included in the study. Daily concentrations of CO, NO2, SO2, O3, PM2.5 and PM10 during the first trimester of pregnancy were assigned to each subject using the nearest monitoring station method. Multivariate logistic regression models were applied to evaluate the associations of monthly average exposure to gaseous air pollutants with orofacial clefts and its subtypes before and after adjusting for particulate matter. Variance inflation factors (VIFs) were used to determine if the effects of gaseous air pollutants could be independent of particulate matter. Results Increase in CO, NO2 and SO2 significantly increased the risk of cleft lip with or without cleft palate (CL/P) in all months during the first trimester of pregnancy, with aORs ranging from 1.39 to 1.48, from 1.35 to 1.61 and from 1.22 to 1.35, respectively. The risk of cleft palate only (CPO) increased with increasing NO2 exposure levels in the first trimester of pregnancy, with aORs ranging from 1.60 to 1.66. These effects sustained and even exacerbated after adjusting for particulate matter. No significant effect of O3 was observed. Conclusions Our study suggested that maternal exposure to CO, NO2, and SO2 during the first trimester of pregnancy might contribute to the development of orofacial clefts, and the associations were potentially independent of particulate matter.

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