scholarly journals P-77 * INTERNET AND GAMING ADDICTION: A SYSTEMATIC LITERATURE REVIEW OF CLINICAL STUDIES

2014 ◽  
Vol 49 (suppl 1) ◽  
pp. i68-i68
Author(s):  
O. Lopez-Fernandez ◽  
D. J. Kuss ◽  
J. Billieux ◽  
M. D. Griffiths
2021 ◽  
Vol 12 (1) ◽  
pp. 33-37
Author(s):  
L. V. Tsoy

The present review describes pathogenetic mechanisms and clinical features of COVID-19 associated delirium. Potential factors leading to the named condition and pathophysiological chains were described elaborately, including older adults’ manifestation analysis based on the latest clinical studies. A systematic literature review was conducted in the following databases: PubMed, Scopus, e-library, Google Scholar and others.


Heliyon ◽  
2019 ◽  
Vol 5 (4) ◽  
pp. e01536 ◽  
Author(s):  
Amit D. Kandhare ◽  
Prasad A. Thakurdesai ◽  
Pralhad Wangikar ◽  
Subhash L. Bodhankar

2021 ◽  
Vol 22 (22) ◽  
pp. 12297 ◽  
Author(s):  
Andrea Palicelli ◽  
Stefania Croci ◽  
Alessandra Bisagni ◽  
Eleonora Zanetti ◽  
Dario De Biase ◽  
...  

In prostate cancer (PC), the PD-1/PD-L1 axis regulates various signaling pathways and it is influenced by extracellular factors. Pre-clinical experimental studies investigating the effects of various treatments (alone or combined) may discover how to overcome the immunotherapy-resistance in PC-patients. We performed a systematic literature review (PRISMA guidelines) to delineate the landscape of pre-clinical studies (including cell lines and mouse models) that tested treatments with effects on PD-L1 signaling in PC. NF-kB, MEK, JAK, or STAT inhibitors on human/mouse, primary/metastatic PC-cell lines variably down-modulated PD-L1-expression, reducing chemoresistance and tumor cell migration. If PC-cells were co-cultured with NK, CD8+ T-cells or CAR-T cells, the immune cell cytotoxicity increased when PD-L1 was downregulated (opposite effects for PD-L1 upregulation). In mouse models, radiotherapy, CDK4/6-inhibitors, and RB deletion induced PD-L1-upregulation, causing PC-immune-evasion. Epigenetic drugs may reduce PD-L1 expression. In some PC experimental models, blocking only the PD-1/PD-L1 pathway had limited efficacy in reducing the tumor growth. Anti-tumor effects could be increased by combining the PD-1/PD-L1 blockade with other approaches (inhibitors of tyrosine kinase, PI3K/mTOR or JAK/STAT3 pathways, p300/CBP; anti-RANKL and/or anti-CTLA-4 antibodies; cytokines; nitroxoline; DNA/cell vaccines; radiotherapy/Radium-223).


Author(s):  
Arndt Büssing ◽  
Thomas Ostermann ◽  
Magdalena Majorek ◽  
Peter F Matthiessen

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