scholarly journals 220P Survival patterns of stage IV liver cancers in the United States

2015 ◽  
Vol 26 ◽  
pp. ix42
Author(s):  
M. Mousa ◽  
A. Meshref ◽  
K. Alsabahy
Keyword(s):  
United States ◽  
Stage Iv ◽  
The United States ◽  
Liver Cancers ◽  
Survival Patterns

scholarly journals PCN12 Survival Patterns by Line of Treatment of Stage IV Colorectal (CRC) Patients From Local Oncology Practice in the United States

2012 ◽  
Vol 15 (4) ◽  
pp. A209
Author(s):  
B. Seal ◽  
S.D. Sullivan ◽  
S. Ramsey ◽  
C. Kreilick ◽  
S. Foltz-Boklage ◽  
...  
Keyword(s):  
United States ◽  
Stage Iv ◽  
The United States ◽  
Survival Patterns ◽  
Oncology Practice

Incidence and Survival Patterns of Sinonasal Undifferentiated Carcinoma in the United States

2014 ◽  
Vol 75 (S 01) ◽  
Author(s):  
Kyle Chambers ◽  
Ashton Lehmann ◽  
Aaron Remenschneider ◽  
Matthew Dedmon ◽  
Bharat Yarlagadda ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Undifferentiated Carcinoma ◽  
Sinonasal Undifferentiated Carcinoma ◽  
Survival Patterns

Breast Cancer

2018 ◽  
Author(s):  
Nancy E Davidson
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Cancer Incidence ◽  
Hormone Replacement ◽  
Breast Cancer Incidence ◽  
Stage Iv ◽  
The United States ◽  
Rate Of Increase ◽  
Stage Iv Breast Cancer ◽  
Incidence And Mortality

Invasive breast cancer, the most common nonskin cancer in women in the United States, will be diagnosed in 266,120 In 2018, along with 63,960 new cases of non-invasive (in situ) breast cancer. Incidence and mortality reached a plateau and appear to be dropping in both the United States and parts of western Europe. This decline has been attributed to several factors, such as early detection through the use of screening mammography and appropriate use of systemic adjuvant therapy, as well as decreased use of hormone replacement therapy. However, the global burden of breast cancer remains great, and global breast cancer incidence increased from 641,000 in 1980 to 1,643,000 in 2010, an annual rate of increase of 3.1%. This chapter examines the etiology, epidemiology, prevention, screening, staging, and prognosis of breast cancer. The diagnoses and treatments of the four stages of breast cancer are also included. Figures include algorithms used for the systemic treatment of stage IV breast cancer and hormone therapy for women with stage IV breast cancer. Tables describe selected outcomes from the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 and P-2 chemoprevention trials, tamoxifen chemoprevention trials for breast cancer, the TNM staging system and stage groupings for breast cancer, some commonly used adjuvant chemotherapy regimens, an algorithm for suggested treatment for patients with operable breast cancer from the 2011 St. Gallen consensus conference, guidelines for surveillance of asymptomatic early breast cancer survivors from the American Society of Clinical Oncology, and newer agents for metastatic breast cancer commercially available in the United States. This review contains 2 highly rendered figures, 8 tables, and 108 references.

Incidence and Survival Patterns of Cranial Chordoma in the United States

2013 ◽  
Vol 74 (S 01) ◽  
Author(s):  
Kyle Chambers ◽  
Aaron Remenschneider ◽  
Josh Meier ◽  
Marc Herr ◽  
Alice Lin ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Survival Patterns

scholarly journals Blood Transfusion and Survival for Resected Adrenocortical Carcinoma: A Study from the United States Adrenocortical Carcinoma Group

2017 ◽  
Vol 83 (7) ◽  
pp. 761-768 ◽  
Author(s):  
Caroline E. Poorman ◽  
Lauren M. Postlewait ◽  
Cecilia G. Ethun ◽  
Thuy B. Tran ◽  
Jason D. Prescott ◽  
...  
Keyword(s):  
United States ◽  
Blood Transfusion ◽  
Adrenocortical Carcinoma ◽  
Cox Regression ◽  
Multivariable Analysis ◽  
Vena Cava ◽  
Stage Iv ◽  
The United States ◽  
Curative Intent ◽  
Stage 4

Perioperative blood transfusion is associated with decreased survival in pancreatic, gastric, and liver cancer. The effect of transfusion in adrenocortical carcinoma (ACC) has not been studied. Patients with available transfusion data undergoing curative-intent resection of ACC from 1993 to 2014 at 13 institutions comprising the United States Adrenocortical Carcinoma Group were included. Factors associated with blood transfusion were determined. Primary and secondary end points were recurrence-free survival (RFS) and overall survival (OS), respectively. Out of 265 patients, 149 were included for analysis. Out of these, 57 patients (38.3%) received perioperative transfusions. Compared to nontransfused patients, transfused patients more commonly had stage 4 disease (46% vs 24%, P = 0.01), larger tumors (15.8 vs 10.2 cm, P < 0.001), inferior vena cava involvement (24.6% vs 5.4%, P = 0.002), additional organ resection (78.9% vs 36.3%, P < 0.001), and major complications (29% vs 2%, P < 0.001). Transfusion was associated with decreased RFS (8.9 vs 24.7 months, P = 0.006) and OS (22.8 vs 91.0 months, P < 0.001). On univariate Cox regression, transfusion, stage IV, hormonal hypersecretion, and adjuvant therapy were associated with decreased RFS. On multivariable analysis, only transfusion [hazard ratio (HR) = 1.7, 95% confidence interval (CI) 51.0–2.9, P = 0.04], stage IV (HR = 3.2, 95% CI = 1.7–5.9, P < 0.001), and hormonal hypersecretion (HR = 2.6, 95% CI = 1.5–4.2, P < 0.001) were associated with worse RFS. When applying this model to OS, similar associations were seen (transfusion HR = 2.0, 95% CI = 1.1–3.8, P = 0.02; stage 4 HR = 6.2, 95% CI = 3.1–12.4, P < 0.001; hormonal hypersecretion HR = 3.5, 95% CI = 1.9–6.4, P < 0.001). There was no difference in outcomes between patients who received 1 to 2 units versus >2 units of packed red blood cells in median RFS (8.9 vs 8.4 months, P = 0.95) or OS (26.5 vs 18.6 months, P = 0.63). Peri-operative transfusion is associated with earlier recurrence and decreased survival after curative-intent resection of ACC. Strategies and protocols to minimize blood transfusion should be developed and followed.

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