scholarly journals Were the more examined lymph nodes the better for stage IA NSCLC patients? A Population Study of the US SEER Database

2019 ◽  
Vol 30 ◽  
pp. vi108
Author(s):  
Liu Huang ◽  
Vanisha Chummun ◽  
Qian Chu ◽  
Yuan Chen
Keyword(s):  
Lymph Nodes ◽  
Population Study ◽  
Seer Database ◽  
The Us ◽  
Stage Ia ◽  
Nsclc Patients

scholarly journals Time Trend of Mediastinal Lymph Node Dissection in Stage IA Non-Small Cell Lung Cancer Patient Who Undergo Lobectomy: a Retrospective Study of Surveillance, Epidemiology, and End Results (SEER) database

2020 ◽  
Author(s):  
Liang Pan ◽  
Ran Mo ◽  
Lin hai Zhu ◽  
Wen feng Yu ◽  
Wang Lv ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Time Trend ◽  
Mediastinal Lymph Node ◽  
Small Cell ◽  
Seer Database ◽  
Node Dissection ◽  
Small Cell Lung ◽  
Stage Ia ◽  
Nsclc Patients

Abstract Background: Although lobectomy with mediastinal lymph node dissection (MLND) is the first option for early-stage non-small cell lung cancer (NSCLC) patients, the time trends of MLND in stage IA NSCLC patients who undergo a lobectomy are not clear still.Methods: We included stage IA NSCLC patients who underwent lobectomy or lobectomy with MLND between 2003 and 2013 in the SEER database. The time trend of MLND was compared among patients who underwent a lobectomy.Results: For stage T1a patients, the lobectomy group and lobectomy with MLND group had no differences in postoperative overall survival (OS) (P=0.34) or lung-cancer specific survival (LCSS) (P=0.18) between 2003 and 2013. For stage T1b patients, the OS (P=0.01) and LCSS (P=0.01) were different between the lobectomy group and the lobectomy with MLND group in the period from 2003 to 2009; however, only OS (P=0.04), not LCSS (P=0.14), was different between the lobectomy group and the lobectomy with MLND group between 2009 and 2013. For T1c patients, the OS (P=0.01) and LCSS (P=0.02) were different between the two groups between 2003 and 2009 but not between 2009 and 2013 (P=0.60; P=0.39). From the Cox regression analysis, we found that the factors affecting OS/LCSS in T1b and T1c patients were age, sex, year of diagnosis, histology, and grade, in which year of diagnosis was the obvious factor (HR=0.79, CI=0.71-0.87; HR=0.73, CI=0.64-0.84).Conclusions: There was a time trend in prognosis differences between the lobectomy group and lobectomy with MLND group for T1b and T1c stage NSCLC patients.

scholarly journals Significance of accurate hilar and intrapulmonary lymph nodes examination in stage IA-IIA non-small cell lung cancer, a retrospective cohort study

2020 ◽  
Author(s):  
Wenyu Zhai ◽  
Fangfang Duan ◽  
Yuzhen Zheng ◽  
Qihang Yan ◽  
Shuqin Dai ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Term Survival ◽  
Differentiation Degree ◽  
Stage Ia ◽  
Nsclc Patients

Abstract Background The examination of lymph node plays an important part in the nodal staging of non-small cell lung cancer (NSCLC). Till present, on the role of hilar and intrapulmonary (N1) station lymph node (LN) examined is not fully appreciated. In this study, we aimed to confirm the significance of N1 lymph node examined in the long-term survival for stage IA-IIA NSCLC patients and find the minimum number of lymph nodes.Methods The data of patients who underwent radical lobectomy and confirmed as lymph node non-metastatsized from January 2008 to March 2018 were retrospectively screened. Pathology records were reviewed for the number of lymph nodes examined. Kaplan-Meier method and Cox regression model were used to identify survival and prognostic factors.Results The median number of resected N1 LNs was 8. The number of patients with 0-2 N1 LNs, 3-5 N1 LNs, 6-8 N1 LNs, 9-11 N1 LNs and more than 11 N1 LNs examined was 181, 425, 477, 414 and 531, respectively. Gender (P=0.004), age (P<0.001), tumor size (P=0.004), differentiation degree (P=0.001) and the number of N1 LNs examined (P=0.008) were the independent prognostic factors of overall survival. Gender (P=0.006), age (P=0.031), tumor size (P=0.001), differentiation degree (P=0.001), vascular invasion (P=0.034) and the number of N1 LNs examined (P=0.007) were the independent prognostic factors of disease-free survival. Conclusion Increasing the number of N1 LNs examination could improve the long-term survival of T1-2N0 NSCLC patients. At least six LNs should be examined in surgical and pathological management.

scholarly journals Role of Removed Lymph Nodes on the Prognosis of M0 Small-Bowel Neuroendocrine Tumors: a Propensity Score Matching Analysis from SEER Database

2021 ◽  
Author(s):  
Jie-bin Xie ◽  
Yue-shan Pang ◽  
Xun Li ◽  
Xiao-ting Wu
Keyword(s):  
Small Bowel ◽  
Propensity Score ◽  
Lymph Nodes ◽  
Propensity Score Matching ◽  
Neuroendocrine Tumors ◽  
Prognostic Value ◽  
Radical Resection ◽  
Clinicopathological Characteristics ◽  
Seer Database ◽  
Resection Group

Abstract Background Current studies on the number of removed lymph nodes (LNs) and their prognostic value in small-bowel neuroendocrine tumors (SBNETs) are limited. This study aimed to clarify the prognostic value of removed LNs for SBNETs. Methods SBNET patients without distant metastasis from 2004 to 2017 in the SEER database were included. The optimal cutoff values of examined LNs (ELNs) and negative LNs (NLNs) were calculated by the X-tile software. Propensity score matching (PSM) was done to match patients 1:1 on clinicopathological characteristics between the two groups. The Kaplan-Meier method with log-rank test and multivariable Cox proportional-hazards regression model were used to evaluate the prognostic effect of removed LNs. Results The cutoff values of 14 for ELNs and 9 for NLNs could well distinguish patients with different prognoses. After 1:1 PSM, the differences in clinicopathological characteristics between the two groups were significantly reduced (all P > 0.05). Removal of more than one LN significantly improved the prognosis of the patients (P < 0.001). The number of lymphatic metastasis in the sufficiently radical resection group (SRR, 3.74 ± 3.278, ELN > 14 and NLN > 9) was significantly more than that in the insufficiently radical resection group (ISRR, 2.72 ± 3.19, ELN < 14 or NLN < 9). The 10-year overall survival (OS) of the SRR was significantly better than that of the ISRR (HR = 1.65, P = 0.001, 95% CI: 1.24–2.19). Conclusion Both ELNs and NLNs can well predict the OS of patients. Systematic removal of more than 14 LNs and more than 9 NLNs can increase the OS of SBNET patients.

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