Aging and Dementia-1Age Moderates the Relationship Between Drug Burden Index and Subjective Cognitive Decline in Members of the Rhode Island Alzheimer Prevention Registry

Few studies have examined the effects of health literacy on people at risk of developing dementia; its effects on the pathogenesis of subjective cognitive decline (SCD) are particularly unclear. This study aimed to clarify the relationship between health literacy and SCD in a population of healthy community-dwelling older adults. SCD status was assessed using the Cognitive Function domain of the Kihon Checklist (KCL-CF). Health literacy, in turn, was evaluated using the Communicative and Critical Health Literacy (CCHL) scale. Global cognitive function and depressive symptoms were evaluated using the Mini-Mental State Examination (MMSE) and a five-item version of the Geriatric Depression Scale (GDS-5), respectively. Participants who were suspected of having SCD were significantly older than their non-SCD peers, and scored significantly worse on the CCHL, MMSE, and GDS-5. In addition, SCD status was found to be associated with CCHL and GDS-5 scores, as well as age, according to a logistic regression analysis. These findings suggest that low health literacy is linked to SCD morbidity in healthy community-dwelling older adults and should prove useful in the planning of dementia prevention and intervention programs for this population.

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The role of depression and anxiety in the relationship between poor sleep quality and subjective cognitive decline in Chinese elderly: exploring parallel, serial, and moderated mediation

Journal of Affective Disorders ◽

10.1016/j.jad.2021.07.063 ◽

2021 ◽

Author(s):

Wen-Qi Xu ◽

Li-Hua Lin ◽

Kai-Rong Ding ◽

Yun-Fei Ke ◽

Jia-Hao Huang ◽

...

Keyword(s):

Sleep Quality ◽

Cognitive Decline ◽

Moderated Mediation ◽

Subjective Cognitive Decline ◽

Poor Sleep ◽

Depression And Anxiety ◽

Poor Sleep Quality ◽

Chinese Elderly ◽

The Relationship

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Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE

Journal of Alzheimer s Disease ◽

10.3233/jad-215373 ◽

2021 ◽

pp. 1-10

Author(s):

Xiaoqi Wang ◽

Qiuhui Bi ◽

Jie Lu ◽

Piu Chan ◽

Xiaochen Hu ◽

...

Keyword(s):

Cognitive Decline ◽

Memory Function ◽

Verbal Learning ◽

Linear Regression Analysis ◽

Brain Regions ◽

Middle Temporal Gyrus ◽

Subjective Cognitive Decline ◽

Amyloid Load ◽

Relationship Of ◽

The Relationship

Background: Subjective cognitive decline (SCD), an at-risk condition of Alzheimer’s disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention. Objective: We aims to explore the differences in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition. Methods: A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition. Results: Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores. Conclusion: According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.

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A-22 Effect of Dementia Experience on the Relationship between Subjective Cognitive Decline, Illness Perceptions, and Dementia Worry

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acab062.40 ◽

2021 ◽

Vol 36 (6) ◽

pp. 1063-1063

Author(s):

Taylor D Lambertus ◽

Julie A Suhr

Keyword(s):

Cognitive Decline ◽

Online Survey ◽

Illness Perceptions ◽

Illness Perception ◽

Subjective Cognitive Decline ◽

Future Research ◽

Related Factor ◽

Health Seeking ◽

Dementia Worry ◽

The Relationship

Abstract Objective Dementia worry (DW) is anxious rumination about personal risk for dementia and may be related to subjective cognitive decline (SCD). Personal experience with dementia may affect DW. Another possibly related factor is illness perceptions, or beliefs about illness which can influence health outcomes. We examined whether SCD and illness perceptions, specifically personal and treatment controllability, predicted DW, and whether dementia experience moderated these effects. Method Ohioans (≥50 years old) completed an online survey. 60 participants reported no personal dementia experience. 100 participants endorsed having a biological relative with dementia. Illness perceptions were measured with a modified Illness Perception Questionnaire focused on cognitive decline. DW was measured with the Dementia Worry Scale and SCD was measured with the Cognitive Function Questionnaire (CFQ). Results In those with no dementia experience, SCD interacted with personal controllability (p = 0.016) and treatment controllability (p = 0.011) to predict DW. SCD and DW were related only in those with high belief that dementia is not personally (p = 0.018) or professionally controllable (0.002). However, in those with dementia experience, there were main effects for SCD (p < 0.001) and treatment controllability (p = 0.006), but no significant interaction. Conclusions Dementia experience and illness perceptions (personal and treatment control) are important factors to consider in the relationship of SCD to DW. Results highlight the importance of illness perceptions and personal dementia experience in health seeking behaviors. Future research should investigate level and frequency of experience in relation to illness perceptions, and examine how educational programs about dementia may influence illness perceptions and DW.

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The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2019.05.011 ◽

2019 ◽

Vol 81 ◽

pp. 22-29 ◽

Cited By ~ 6

Author(s):

Sepideh Shokouhi ◽

Alexander C. Conley ◽

Suzanne L. Baker ◽

Kimberly Albert ◽

Hakmook Kang ◽

...

Keyword(s):

Cognitive Decline ◽

Subjective Cognitive Decline ◽

Elderly Adults ◽

Domain Specific ◽

Alzheimer’S Pathology ◽

The Relationship

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A-025 Subjective Cognitive Decline and Likelihood of Participation Across Home-Based Cognitive Assessment Modalities

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acaa068.025 ◽

2020 ◽

Vol 35 (6) ◽

pp. 815-815

Author(s):

Splonskowski M ◽

Smith S ◽

Jacova C

Keyword(s):

Cognitive Decline ◽

Cognitive Assessment ◽

Help Seeking ◽

Symptom Burden ◽

Community Dwelling ◽

Cognitive Testing ◽

Amazon Mechanical Turk ◽

Subjective Cognitive Decline ◽

Home Based ◽

The Relationship

Abstract Objective Individuals with subjective cognitive decline (SCD) are approximately twice as likely to develop dementia and less likely to seek cognitive assessment. Home-based cognitive assessment (HBCA) could reduce many practical and emotional barriers associated with in-person cognitive testing. We aimed to explore the relationship between SCD and likelihood of HBCA participation across various modalities. Method A nation-wide sample of 483 community-dwelling adults age 50 years and older (M = 63.61 ± 5.47) were recruited via Amazon Mechanical Turk, an online crowdsourcing website, to complete a survey. SCD was measured using the SCD-MyCog Questionnaire. A score of 7/24 endorsed symptoms classified respondents into SCD and non-SCD. Likelihood of participation in HBCA was measured using 4 likert-scale items (e.g., “How likely would you be to participate in HBCA via computer?”). Total likelihood was calculated by summing items. Results Regression revealed SCD symptom burden predicted likelihood of participation in HBCA [F(1, 481) = 12.42, B = .097, [.043–.150], p < .001, r^2 = .025]. Likelihood was higher in SCD (15.25 ± 3.3) than non-SCD (14.23 ± 3.5). When looking at specific HBCA modalities, SCD were more likely than non-SCD to participate in computer and videoconferencing modalities (1.36 ± 0.6 vs1.68 ± 0.87, p < .001; 2.26 ± 1.11 vs 2.58 ± 1.16, p < .001). There was no relationship with iPad or smartphone modalities. Conclusion SCD endorsement was associated with increased likelihood of engagement in HBCA. It is possible that HBCA can help overcome barriers to help-seeking in this group. SCD may prefer videoconferencing and computer modalities.

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Older Adults’ Subjective Cognitive Decline Correlated with Subjective but Not Objective Sleep: A Mediator Role of Depression

The International Journal of Aging and Human Development ◽

10.1177/00914150211024186 ◽

2021 ◽

pp. 009141502110241

Author(s):

Hai-Xin Jiang ◽

Xin Xie ◽

Yang Xu ◽

Rui Wang ◽

Xu Lei ◽

...

Keyword(s):

Older Adults ◽

Cognitive Decline ◽

The Elderly ◽

Community Dwelling ◽

Subjective Cognitive Decline ◽

Depression Symptoms ◽

Targeted Interventions ◽

Sleep Parameters ◽

The Relationship

This study examined the relationship between older adults’ subjective versus objective sleep and subjective cognitive decline (SCD), and explored the role of depression on this association. One hundred and four community-dwelling older adults underwent a week of actigraphic sleep monitoring, and completed a series of neuropsychological screeners. Older adults’SCD score was positively correlated with subjective insomnia, but not with objective sleep parameters. Further mediation modeling revealed that older adults’depression mediated the association between subjective insomnia and SCD. Subjective sleep, rather than objective sleep, may be a more sensitive indicator for older adults’ SCD, with depression symptoms appearing to account for most of the variance. These findings extend our perspective on the relationship between sleep disruption and cognitive decline, and highlight the necessity of early targeted interventions on sleep to reduce the risk of cognitive impairment in the elderly with SCD.

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