scholarly journals A Case of total Traumatic Lesion of the Spinal Cord at the Junction of the Cervical and Dorsal Regions

Brain ◽  
1895 ◽  
Vol 18 (1) ◽  
pp. 175-179 ◽  
Author(s):  
Ludwig Bruns ◽  
C. S. SHERINGTON
Keyword(s):  
Spinal Cord ◽  
Traumatic Lesion

scholarly journals Different Traumatic Spinal Column Fractures and Traumatic Spinal Cord Injury: An Epidemiologic Study

2020 ◽  
Vol 7 (2) ◽  
pp. 67-72
Author(s):  
Ali Andalib ◽  
◽  
Hossein Akbari Aghdam ◽  
Emran Ahmadi ◽  
◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Epidemiologic Study ◽  
Spinal Column ◽  
Traumatic Spinal Cord Injury ◽  
Spine Fractures ◽  
Road Accidents ◽  
Traumatic Injuries ◽  
Traumatic Lesion ◽  
Cord Injury

Background: Trauma and traumatic injuries are the most common causes of disabilities among the young population in developing countries. Besides morbidity and mortality, traumatic injuries can significantly decrease the quality of life and life expectancy of the victims. Objectives: Traumatic Spinal Cord Injury (TSCI) is an acute, traumatic lesion of the spinal cord. It usually produces economic problems that can emotionally and psychologically affect the patients. This study aims to evaluate spinal column fractures and TSCI in Iran. Methods: In this study, we evaluated all of the cases diagnosed with TSCIs between 2012 and 2018. A total of 1014 patients were included in our study. Prevalence of spinal column fractures was evaluated and the percentage of each type of fractures was extracted. The need for surgery and the percentage of TSCI were also evaluated. Results: The most common cause of trauma was vehicle and road accidents (83.4%) followed by falling (12.7%). A total of 21 patients (2.1%) died due to injuries. The incidence of TSCI among patients with traumatic spinal column fractures were 62 cases (6.1%). Also, 67.7% of patients with TSCI underwent surgery. Furthermore, we found that the lumbar area received the highest incidence of TSCI (38.3% of all TSCIs) followed by thoracic spine fractures (27.4% of all TSCIs). Also thoracic and cervical spine fractures were mostly associated with mortality compared with other sites of spine fractures (47.6% and 38.1% of all mortalities, respectively). Conclusion: In our study, most cases (83.4%) were injured by road accidents which indicates the low safety of vehicles and roads in Iran. Epidemiological features of spinal column injuries and TSCI vary among different societies due to different causes. So far, this study is the first one to evaluate different spine fractures and TSCI and other associated factors in the Iranian population.The results indicate a high incidence of thoracic and lumbar fractures and a higher mortality rate in thoracic and cervical fractures.

Reparixin, an Inhibitor of CXCR2 Function, Attenuates Inflammatory Responses and Promotes Recovery of Function after Traumatic Lesion to the Spinal Cord

2007 ◽  
Vol 322 (3) ◽  
pp. 973-981 ◽  
Author(s):  
Alfredo Gorio ◽  
Laura Madaschi ◽  
Giorgia Zadra ◽  
Giovanni Marfia ◽  
Barbara Cavalieri ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Inflammatory Responses ◽  
Recovery Of Function ◽  
Traumatic Lesion

Expression of tenascin R and J1 mRNA in motoneurons after a traumatic lesion in the spinal cord

Neuroreport ◽  
2001 ◽  
Vol 12 (16) ◽  
pp. 3513-3517 ◽  
Author(s):  
T. Lindholm ◽  
S. Cullheim ◽  
T. Carlstedt ◽  
M. Risling
Keyword(s):  
Spinal Cord ◽  
Traumatic Lesion

Upregulation in Rat Spinal Cord Microglia of the Nonintegrin Laminin Receptor 37 kDa-LRP following Activation by a Traumatic Lesion or Peripheral Injury

2009 ◽  
Vol 26 (2) ◽  
pp. 195-207 ◽  
Author(s):  
Hasna Baloui ◽  
Olivier Stettler ◽  
Stefan Weiss ◽  
Fatiha Nothias ◽  
Ysander von Boxberg
Keyword(s):  
Spinal Cord ◽  
Laminin Receptor ◽  
Rat Spinal Cord ◽  
Traumatic Lesion ◽  
Peripheral Injury

scholarly journals Diosgenin Glucoside Protects against Spinal Cord Injury by Regulating Autophagy and Alleviating Apoptosis

2018 ◽  
Vol 19 (8) ◽  
pp. 2274 ◽  
Author(s):  
Xian-Bing Chen ◽  
Zi-Li Wang ◽  
Qing-Yu Yang ◽  
Fang-Yu Zhao ◽  
Xiao-Li Qin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Potential ◽  
Tissue Injury ◽  
Treated Group ◽  
Control Group ◽  
Sprague Dawley ◽  
Neuroprotective Effects ◽  
Traumatic Lesion ◽  
Cord Injury

Spinal cord injury (SCI) is a severe traumatic lesion of central nervous system (CNS) with only a limited number of restorative therapeutic options. Diosgenin glucoside (DG), a major bioactive ingredient of Trillium tschonoskii Max., possesses neuroprotective effects through its antioxidant and anti-apoptotic functions. In this study, we investigated the therapeutic benefit and underlying mechanisms of DG treatment in SCI. We found that in Sprague-Dawley rats with traumatic SCI, the expressions of autophagy marker Light Chain 3 (LC3) and Beclin1 were decreased with concomitant accumulation of autophagy substrate protein p62 and ubiquitinated proteins, indicating an impaired autophagic activity. DG treatment, however, significantly attenuated p62 expression and upregulated the Rheb/mTOR signaling pathway (evidenced as Ras homolog enriched in brain) due to the downregulation of miR-155-3p. We also observed significantly less tissue injury and edema in the DG-treated group, leading to appreciable functional recovery compared to that of the control group. Overall, the observed neuroprotection afforded by DG treatment warrants further investigation on its therapeutic potential in SCI.

scholarly journals DIAGNOSIS DAN PENATALAKSANAAN CEDERA SERVIKAL MEDULA SPINALIS

2014 ◽  
Vol 5 (3) ◽  
Author(s):  
Junita P. S. Maja
Keyword(s):  
Spinal Cord ◽  
Ct Scan ◽  
High Dose ◽  
Cervical Injury ◽  
Traumatic Lesion ◽  
Main Complaint ◽  
Cord Injury ◽  
Central Cord Syndrome ◽  
Cervical Injuries ◽  
Time Of Admission

Abstract: Spinal cord injury is a traumatic lesion of the spinal cord which causes neurological disorders. The symptoms vary from pain, paralysis, and the occurence of incontinence, depending on the location of the injured spinal cord. The damage of the spinal cord may be incomplete or complete. We reported a 55-year-old male with his main complaint being weakness throughout all four limbs which occured after a fall with a hyperextended neck position. At the time of admission, the duration of injury was 12 hours. Physical examinations showed motoric and sensoric disorders, without any autonomic abnormalities. Cervical radiographics and a CT scan revealed no abnormalities, whereas the MRI images showed a contusion at C3. The management of this case included stabilization of the neck, a protocol treatment for cervical injuries, an administration of a high-dose of methylprednisolone, prevention of complications, and a regular session of physiotherapy. During treatment, the patient showed a significant progression in both motoric and sensoric functions. Conclusion: Based on all the tests performed and the follow-up, the diagnosis of this case was central cord syndrome (CCS) due to incomplete cervical medulla spinalis injury. Keywords: cervical injury, spinal cord, diagnosis, treatment   Abstrak: Trauma medula spinalis adalah trauma pada tulang belakang yang menyebabkan lesi di medula spinalis sehingga menimbulkan gangguan neurologik. Gejala-gejala dapat bervariasi mulai dari nyeri, paralisis sampai terjadinya inkontinensia, dan sangat bergantung pada lokasi medula spinalis yang mengalami cedera. Kerusakan medula spinalis dapat bersifat “inkomplit” dan “komplit”. Kami melaporkan kasus seorang laki-laki 55 tahun dengan kelemahan keempat anggota gerak yang terjadi setelah terjatuh dengan posisi leher yang hiperekstensi. Saat masuk rumah sakit, cedera sudah berlangsung selama 12 jam. Pada pemeriksaan fisik ditemukan gangguan motorik dan sensorik, sedangkan otonom tidak ditemukan kelainan. Gambaran radiologik foto servikal dan CT-Scan servikal tidak terdapat kelainan, sedangkan pada MRI tampak gambaran kontusio di segmen medula spinalis C3. Penanganan pada kasus ini yaitu stabilisasi leher, tatalaksana umum untuk cedera leher, pemberian metilprednisolon dosis tinggi, pencegahan komplikasi yang muncul, dan fisioterapi yang teratur. Selama perawatan pasien menunjukkan kemajuan yang berarti, baik dari fungsi motorik maupun sensorik. Simpulan: Berdasarkan hasil pemeriksaan yang telah dilakukan dan pemantauan lanjut selama perawatan, diagnosis yang ditegakkan ialah central cord syndrome (CCS) akibat cedera medula spinalis servikal inkomplit. Kata kunci: cedera servikal, medula spinalis, diagnosis, tatalaksana

scholarly journals Biomaterial Approaches to Enhancing Neurorestoration after Spinal Cord Injury: Strategies for Overcoming Inherent Biological Obstacles

2015 ◽  
Vol 2015 ◽  
pp. 1-20 ◽  
Author(s):  
Justin R. Siebert ◽  
Amber M. Eade ◽  
Donna J. Osterhout
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Spinal Cord Injury ◽  
Nervous System ◽  
Biological Response ◽  
Neural Regeneration ◽  
Therapeutic Interventions ◽  
Traumatic Lesion ◽  
Cord Injury ◽  
The Central Nervous System

While advances in technology and medicine have improved both longevity and quality of life in patients living with a spinal cord injury, restoration of full motor function is not often achieved. This is due to the failure of repair and regeneration of neuronal connections in the spinal cord after injury. In this review, the complicated nature of spinal cord injury is described, noting the numerous cellular and molecular events that occur in the central nervous system following a traumatic lesion. In short, postinjury tissue changes create a complex and dynamic environment that is highly inhibitory to the process of neural regeneration. Strategies for repair are outlined with a particular focus on the important role of biomaterials in designing a therapeutic treatment that can overcome this inhibitory environment. The importance of considering the inherent biological response of the central nervous system to both injury and subsequent therapeutic interventions is highlighted as a key consideration for all attempts at improving functional recovery.

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