Study of temperature logs of linseed, corn and chia seeds for the treatment of joint pain and inflammation

Thermal energy storage in the form of heat provides transient relief in inflammatory and traumatic, subacute and chronic disorders such as: sprains, muscle strains, muscle spasms, low back pain, cervical injuries, various forms of arthritis, arthralgia, neuralgia. Heat increases blood flow and connective tissue extensibility; it also decreases joint stiffness, pain and muscle spasm and helps relieve inflammation. The application of heat can be superficial and the intensity or duration of the physiological effects depends mainly on the temperature of the tissue, the rate of temperature elevation and the area treated. In this work a comparison of the capacity to absorb and contain sensible heat using a combination of linseed, corn and chia seeds in water is made in order to identify which combination is able to retain heat longer and to take advantage of this characteristic in the treatment of pain and inflammation.

Magnetic Resonance Imaging of the Cervical Spine: Frequency of Abnormal Findings with Relation to Age

Background: Patients with neck pain are frequently encountered in cervical spine (C-spine) magnetic resonance imaging (MRI) practice. However, the exact distribution and prevalence of cervical abnormalities are not known. Aim: The aim of this study is to evaluate the association between age, gender, and prevalence of abnormal cervical MRI findings. Methods: Records of 111 cervical MRIs were collected in 12 months from January to December 2019 from adults aged 20–89 years who were referred from neurosurgery, neurology, and orthopedic clinics. Findings were classified and analyzed using the Statistical Package for Social Science (SPSS), version 24.0 (IBM, Armonk, NY, USA). The chi-square test was used to determine the association between demographics and abnormalities using a significance of p = 0.05. Results: The majority of patients were female (72.1%). The number of abnormal incidences increased with age until it reached a peak at ages 50–59. Spondylodegenerative changes were the most frequent finding, which was present in 52.2% of the total sample, and was followed by disc bulge (25.2%). Incidences increased in lower discs, with C5–C6 being the most frequent in 65% of the total sample. Younger males in their 20s had more injuries than females of the same age. However, this rate was reversed in patients over 40, as women were the dominant gender among patients in their 40s with cervical injuries, with a rate of 81.5%. Conclusion: In our study, we found that older patients developed more C-spine injuries. Gender may play a role in the rate of incidents. However, we did not find any significant differences between men and women or between different types of abnormalities.

An Osteological Study of Anatomical Variations of Foramen Transversarium of Cervical Vertebrae and its Clinical Implications

Background: In cervical vertebrae, the costal and transverse elements are connected to each other around the foramen transversarium of the transverse process. The adult cervical vertebrae are characterized by the presence of Foramen Transversarium (FT) in transverse process. These transverse foramina are found to have variations in size, shape and numbers and may be absent, incomplete or duplicate, which may lead to various symptoms. Aim: To study the anatomical variations of cervical vertebrae. Materials and methods: The present observational study was performed on 182 dry human cervical vertebrae of unknown sex and age. Intact cervical vertebrae without any degenerative or traumatic disorders were included in this study. Deformed and damaged vertebrae were excluded from the study Results: Out of these 364 foramen transversarium, 98 (27%) foramen transversarium were of type-I. Type -I was the most common presentation in the present study. Type -II foramen transversarium were seen in 33 (09%) foramen transversarium. Out of 364 foramen transversarium 88 (24%) foramen transversarium were of type-III. Type-IV foramen transversarium were seen in 62 (17%) foramen transversarium. Type-V foramen transversarium were seen on 83 (23%) foramen transversarium. Out of 182 vertebrae 40 (22%) showed complete double foramen transversarium. Incomplete double foramen transversarium were seen in 24 (13%) of vertebrae. One side complete & other side incomplete foramen transversarium were seen in 04 (02%) vertebrae. Conclusion: Knowledge of such variations is important for Physicians, Neurologists Otorhinolaryngologists, radiologists and Orthopedicians. Presence of accessory foramen transversarium especially of incomplete variety, the second part of vertebral artery may be dislodged and prone to get damaged easily during posterior cervical injuries. It helps in radiological imaging, neurological diagnosis and complex surgical procedures in the cervical area. KEY WORDS: Cervical Vertebrae, Foramen transversarium, Accessory Foramen Transversarium.

Development of a Spinal Cord Injury Model Permissive to Study the Cardiovascular Effects of Rehabilitation Approaches Designed to Induce Neuroplasticity

As primary medical care for spinal cord injury (SCI) has improved over the last decades there are more individuals living with neurologically incomplete (vs. complete) cervical injuries. For these individuals, a number of promising therapies are being actively researched in pre-clinical settings that seek to strengthen the remaining spinal pathways with a view to improve motor function. To date, few, if any, of these interventions have been tested for their effectiveness to improve autonomic and cardiovascular (CV) function. As a first step to testing such therapies, we aimed to develop a model that has sufficient sparing of descending sympathetic pathways for these interventions to target yet induces robust CV impairment. Twenty-six Wistar rats were assigned to SCI (n = 13) or naïve (n = 13) groups. Animals were injured at the T3 spinal segment with 300 kdyn of force. Fourteen days post-SCI, left ventricular (LV) and arterial catheterization was performed to assess in vivo cardiac and hemodynamic function. Spinal cord lesion characteristics along with sparing in catecholaminergic and serotonergic projections were determined via immunohistochemistry. SCI produced a decrease in mean arterial pressure of 17 ± 3 mmHg (p < 0.001) and left ventricular contractility (end-systolic elastance) of 0.7 ± 0.1 mmHg/µL (p < 0.001). Our novel SCI model produced significant decreases in cardiac and hemodynamic function while preserving 33 ± 9% of white matter at the injury epicenter, which we believe makes it a useful pre-clinical model of SCI to study rehabilitation approaches designed to induce neuroplasticity.

Proposal of Treatment Strategy for Pedicle Fractures of the C2: An Analysis of 49 Cases

Spine surgeons often confuse C2 pedicle fractures (PFs) with pars interarticularis fractures. In addition, little information is available about the characteristics and treatment strategies for C2 PFs. We sought to investigate the characteristics of C2 PFs and to propose an appropriate treatment strategy. A total of forty-nine patients with C2 PFs were included in this study. We divided these patients into unilateral and bilateral C2 PF groups. The incidence rates and characteristics of other associated C2 and C2-3 injuries, and other cervical injuries, were evaluated. In addition, treatment methods and outcomes were analyzed. Twenty-two patients had unilateral C2 PFs and twenty-seven patients had bilateral C2 PFs. Among the cases of unilateral C2 PFs, all patients had one or more other C2 fractures, and twenty patients (90.9%) had one or two C2 body fractures. Meanwhile, among the cases of bilateral C2 PF, all patients had two or more other C2 fractures and one or two C2 body fractures. In unilateral C2 PFs, three patients with C2-3 anterior slip or adjacent cervical spine (C1-3) injury underwent surgery and nineteen patients (86.4%) were treated with conservative methods. In bilateral C2 PFs, three patients with C2-3 anterior slip or SCI at C2-3 underwent surgery and twenty-four patients (88.9%) were treated with conservative methods. Our results showed that C2 PFs do not occur alone and are always accompanied by other associated C2 injuries. C2 PFs should, generally, be thought of as a more complex fracture type than hangman’s fracture or dens fracture. Despite the complex fracture characteristics, most C2 PFs can be managed with conservative treatment. However, surgical treatments should be considered if the C2 PFs are accompanied by the C2-3 anterior slip and adjacent cervical spine injury.

Cervical Spine Clearance on Trauma Intensive Care: Can We Trust a Negative CT Scan?

Background: Cervical spine clearance in intubated victims of blunt trauma remains contentious; accumulating high level evidence suggests that a normal CT cervical spine can be used to clear the c-spine and remove the collar in obtunded emergency department patients to prevent collar-related complications. However, it is unclear whether this holds true for intubated patients in the trauma intensive care unit (TICU).Methods: We performed a retrospective review of 730 intubated trauma patients who presented to the Level 1 Trauma center of a tertiary hospital. We reviewed the rate of missed cervical injuries in patients who had their cervical collars removed based on a normal computed tomography (CT) scan of the cervical spine, as well as rates of collar-related complications.Results: Three hundred and fifty patients had their cervical collars removed in the TICU based on the findings of a high-quality, well-interpreted normal CT cervical spine. Seventy percent of patients were intubated and sedated at the time of collar removal. Fifty-one percent of patients had concomitant traumatic brain injury. The average GCS at time of collar removal was 9. The incidence of missed neurological injury discerned clinically at time of both ICU and hospital discharge was nil (negative predictive value 100%). The rate of collar-related complications was 2%.Conclusion: Based on our findings, it is safe to remove the cervical collar for patients in the TICU following normal CT cervical spine, provided certain quality conditions related to the CT scan are met. Not removing the collar early may be related to increased complications. We provide an algorithm to assist critical-care clinicians in decision-making in this patient cohort

Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord

Spinal cord injury (SCI) leads to dramatic impairments of motor, sensory, and autonomic functions of affected individuals. Following the primary injury, there is an increased release of glutamate that leads to excitotoxicity and further neuronal death. Therefore, modulating glutamate excitotoxicity seems to be a promising target to promote neuroprotection during the acute phase of the injury. In this study, we evaluated the therapeutic effect of a FDA approved antiepileptic drug (levetiracetam-LEV), known for binding to the synaptic vesicle protein SV2A in the brain and spinal cord. LEV therapy was tested in two models of SCI—one affecting the cervical and other the thoracic level of the spinal cord. The treatment was effective on both SCI models. Treated animals presented significant improvements on gross and fine motor functions. The histological assessment revealed a significant decrease of cavity size, as well as higher neuronal and oligodendrocyte survival on treated animals. Molecular analysis revealed that LEV acts by stabilizing the astrocytes allowing an effective uptake of the excess glutamate from the extracellular space. Overall, our results demonstrate that Levetiracetam may be a promising drug for acute management of SCI.