scholarly journals Frequent neurocognitive deficits after recovery from mild COVID-19

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Marcel S Woo ◽  
Jakob Malsy ◽  
Jana Pöttgen ◽  
Susan Seddiq Zai ◽  
Friederike Ufer ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Telephone Interview ◽  
Acute Infection ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Cognitive Status ◽  
Neurocognitive Deficits ◽  
Cross Sectional ◽  
Neuropsychiatric Complications ◽  
Moderate Disease

Abstract Neuropsychiatric complications associated with coronavirus disease 2019 caused by the Coronavirus SARS-CoV-2 (COVID-19) are increasingly appreciated. While most studies have focussed on severely affected individuals during acute infection, it remains unclear whether mild COVID-19 results in neurocognitive deficits in young patients. Here, we established a screening approach to detect cognitive deficiencies in post-COVID-19 patients. In this cross-sectional study, we recruited 18 mostly young patients 20–105 days (median, 85 days) after recovery from mild to moderate disease who visited our outpatient clinic for post-COVID-19 care. Notably, 14 (78%) patients reported sustained mild cognitive deficits and performed worse in the Modified Telephone Interview for Cognitive Status screening test for mild cognitive impairment compared to 10 age-matched healthy controls. While short-term memory, attention and concentration were particularly affected by COVID-19, screening results did not correlate with hospitalization, treatment, viremia or acute inflammation. Additionally, Modified Telephone Interview for Cognitive Status scores did not correlate with depressed mood or fatigue. In two severely affected patients, we excluded structural or other inflammatory causes by magnetic resonance imaging, serum and cerebrospinal fluid analyses. Together, our results demonstrate that sustained sub-clinical cognitive impairments might be a common complication after recovery from COVID-19 in young adults, regardless of clinical course that were unmasked by our diagnostic approach.

Desigualdade social em doentes renais crônicos/ Social inequality in chronic renal patients

1970 ◽  
Vol 1 (1) ◽  
pp. 44-49
Author(s):  
Beatriz Bertolaccini Martínez ◽  
Fernanda Marcelino Da Silva ◽  
Vinícius Tavares Veiga ◽  
Rodrigo Pereira Custódio ◽  
José Vítor Da Silva
Keyword(s):  
Social Inequality ◽  
Access To Health Care ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Access To Health Services ◽  
Access To Treatment ◽  
Cross Sectional ◽  
Economic Class ◽  
Access To Health ◽  
Clinical Background

Introdução: A pobreza influencia na evolução dos pacientes com doenças crônicas, porque contribui para o seu agravamento e dificulta o acesso à assistência médica. O objetivo deste trabalho foi avaliar os aspectos relacionados à desigualdade social de pacientes em hemodiálise. Métodos: Estudo transversal com 123 pacientes em hemodiálise no Hospital Samuel Libânio – Pouso Alegre, MG, divididos, de acordo com a classe econômica, em 3 grupos: AB (n=23), C (n=60) e DE (n=40),. Foram coletados dados sociodemográficos e econômicos, antecedentes clínicos e informações sobre o acesso a serviços de saúde. Para a análise dos resultados, foi utilizada estatística analítica e descritiva. Adotou-se p £ 0,05. Resultados: O grupo AB apresentou um menor número de pacientes jovens (4,3% em AB vs 40% em C e 25% em DE, p < 0,05), um maior número de indivíduos com mais anos de escolaridade (65,3% em AB vs 18,3% em C e 2,5% em DE; p < 0,05), predomínio de pacientes com menos de um ano em tratamento de hemodiálise (65,2% em AB vs 10% em C e 5% em DE, p < 0,05), menor número de usuários do SUS (40% em C e 25% em DE vs 4,3% em AB; p < 0,05) e maior acesso ao tratamento com nefrologista (73,9% em AB vs 46,7% em C e 52,5 em DE; p < 0,05). Conclusão: Classes economicamente desfavorecidas agregam indivíduos mais jovens, com menor escolaridade, usuários do SUS, com maior tempo em hemodiálise e pior acesso ao tratamento com nefrologista.Introduction: The poverty influence on the evolution of patients with chronic diseases because it contributes to your aggravation and hinders access to health care. Our goal was to evaluate the aspects related to social inequality on hemodialysis patients. Methods: cross-sectional study with 123 patients on hemodialysis in Samuel Libânio Hospital – Pouso Alegre, MG, divided according to the economic class, into 3 groups: AB (n = 23), C (n = 60) and DE (n = 40). Were collected socio-demographic and economic data, clinical background and information about access to health services. For analysis of the results has been used statistical analytical and descriptive. We take p £ 0,05.  Results: The AB group has fewer young patients (4,3% in AB vs 40% in C and 25% in DE, p< 0,05), a greater number of individuals with more years of schooling (65,3% in AB vs 18,3% in C and 2,5% in DE; p< 0,05), predominance of patients with less than a year on haemodialysis treatment (65,2% in AB vs 10% in C and 5% in DE, p< 0,05), smaller number of users of SUS (40% in C and 25% in DE vs 4,3% in AB; p< 0,05), greater access to treatment with nephrologist (73,9% in AB vs 46,7% in C and 52,5% in DE; p< 0,05). Conclusion: Economically disadvantaged classes bring younger patients, with less schooling, users of SUS, patients with greater time on hemodialysis and worse access to treatment with nephrologist. 

scholarly journals Gangguan Kognitif pada Pasien Pasca Sembuh Dari Covid-19

2021 ◽  
Vol 6 (6) ◽  
pp. 2935
Author(s):  
Ni Made Gitaria Sylvana Ratmadewi ◽  
Rudy Dwi Laksono ◽  
Laura Bianca Sylvia Huwae
Keyword(s):  
Random Sampling ◽  
Telephone Interview ◽  
Cognitive Status ◽  
Cross Sectional ◽  
Blood Brain

Pasien yang sembuh dari Covid-19 memiliki beberapa keluhan pada daya ingat. Virus corona dapat menembus ke SSP (Sistem Saraf Pusat) dan cairan serebrospinal dalam waktu kurang dari seminggu. Pemeriksaan histopatologi otak pasien Covid-19 yang meninggal menunjukkan potensi SARS-CoV-2 menginfeksi ke sistem saraf pusat (SSP). Neuro inflamasi juga dapat merusak BBB (Blood Brain Barier). Setelah BBB terganggu, sitokin dapat masuk ke SSP dan menyebabkan aktivasi mikroglial dan stres oksidatif, yang menyebabkan gangguan kognitif. Metode Penelitian dilakukan secara cross sectional random sampling terhadap pasien di Ruang Isolasi Covid-19 Rumah Sakit Tingkat II. Prof. dr. J.A Latumeten Ambon selama periode Maret 2020 sampai dengan Maret 2021 dengan melakukan wawancara menggunakan Telephone Interview for Cognitive Status-M (TICS-M) yang terdiri dari 22 pertanyaan dengan total nilai 50. Dari 167 pasien, terdapat 54 pasien yang bersedia di wawancara dan terdapat 28 pasien yang memiliki kecenderungan gangguan cognitive ringan dengan rentang usia 31-40 tahun. Penelitian ini menemukan bahwa nilai TICS-M pada pasien pasca Covid-19 berhubungan dengan usia, namun tidak berhubungan dengan jenis kelamin dan lamanya pendidikan.

scholarly journals Predictive Factors of Development of Graves’ Ophthalmopathy for Patients with Juvenile Graves’ Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Dalia Jarusaitiene ◽  
Rasa Verkauskiene ◽  
Vytautas Jasinskas ◽  
Jurate Jankauskiene
Keyword(s):  
Predictive Factors ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Graves Disease ◽  
Cross Sectional ◽  
Ocular Manifestations ◽  
Graves Ophthalmopathy ◽  
Graves Orbitopathy ◽  
Low Incidence ◽  
Major Factors

Background. Due to low incidence of Graves’ ophthalmopathy (GO) among children, the manifestation is poorly analyzed, posing a risk to late identification of insidious disease.Purposes. To identify predictive factors that may influence the development of GO in pediatric and young patients with Graves’ disease (GD).Methods. A cross-sectional study of patients newly diagnosed with pediatric or juvenile GD during 2002–2012 was conducted at the Hospital of Lithuanian University of Health Sciences. Ocular evaluation was based on European Group on Graves’ Orbitopathy survey. The ocular manifestations were analyzed in relation to demographic, environmental, and clinical factors.Results. In total, 130 patients with juvenile GD were included; 29.2% had GO. Median age at GD onset was 17 yrs (IQR 4–29). Main symptoms of GO were eyelids retraction (73.7%), proptosis (65.8%), injection of conjunctiva (42.1%), and eyeball motility disturbance (21.1%). Major significant and independent risk factors for GO development were high initial concentration of FT4 (OR = 5.963), TTHAb (OR = 6.358), stress (OR = 6.030), and smoking (OR = 7.098).Conclusion. The major factors that could influence GO development were smoking, stress, and increased levels of initial TRAb, FT4. Slight proptosis, retraction of eyelids, and conjunctive injection were found as predominant ophthalmological symptoms in juvenile GO.

Screening children at risk for developmental disabilities based on face landmark from video data of mobile-based application: Cross-Sectional Study (Preprint)

2021 ◽  
Author(s):  
Yu Rang Park ◽  
Sang Ho Hwang ◽  
Yeonsoo Yu ◽  
Jichul Kim ◽  
Taeyeop Lee ◽  
...  
Keyword(s):  
Deep Learning ◽  
Developmental Disabilities ◽  
Early Detection ◽  
Short Term Memory ◽  
Preliminary Evidence ◽  
Cross Sectional Study ◽  
Important Variable ◽  
Video Data ◽  
Classification Model ◽  
Cross Sectional

BACKGROUND Early detection and intervention of developmental disabilities (DDs) are critical for improving the long-term outcomes of the afflicted children. Mobile-based applications are easily accessible and may thus help the early identification of DDs. OBJECTIVE We aimed to identify facial expression and head pose based on face landmark data extracted from face recording videos and to differentiate the characteristics between children with DDs and those without. METHODS Eighty-nine children (DD, n=33; typically developing, n=56) were included in the analysis. Using the mobile-based application, we extracted facial landmarks and head poses from the recorded videos and performed Long Short-Term Memory(LSTM)-based DD classification. RESULTS Stratified k-fold cross-validation showed that the average values of accuracy, precision, recall, and f1-score of the LSTM based deep learning model of DD children were 88%, 91%,72%, and 80%, respectively. Through the interpretation of prediction results using SHapley Additive exPlanations (SHAP), we confirmed that the nodding head angle variable was the most important variable. All of the top 10 variables of importance had significant differences in the distribution between children with DDs and those without (p<0.05). CONCLUSIONS Our results provide preliminary evidence that the deep-learning classification model using mobile-based children’s video data could be used for the early detection of children with DDs.

Clinical Profile of Young Patients with Erectile Dysfunction: Preliminary Findings of a Real-life Cross-sectional Study

2020 ◽  
Vol 6 (1) ◽  
pp. 184-189 ◽  
Author(s):  
Edoardo Pozzi ◽  
Paolo Capogrosso ◽  
Francesco Chierigo ◽  
Filippo Pederzoli ◽  
Eugenio Ventimiglia ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Real Life ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Clinical Profile ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Theory of mind impairment in Huntington's disease patients and their relatives

2019 ◽  
Vol 77 (8) ◽  
pp. 574-578 ◽  
Author(s):  
Leo Bayliss ◽  
Víctor Galvez ◽  
Adriana Ochoa-Morales ◽  
Mireya Chávez-Oliveros ◽  
Yaneth Rodríguez-Agudelo ◽  
...  
Keyword(s):  
Theory Of Mind ◽  
Interpersonal Relationships ◽  
Psychiatric Symptoms ◽  
Genetic Disorder ◽  
Mental States ◽  
Cross Sectional Study ◽  
Degree Relative ◽  
Cross Sectional ◽  
Moderate Disease ◽  
Gene Test

ABSTRACT Huntington disease (HD) is an autosomal dominant genetic disorder characterized by movement disorders, cognitive impairment, and psychiatric symptoms. Relatives of HD patients experience a great burden as the latter suffer from altered social conduct and deterioration of interpersonal relationships. Theory of mind (ToM) is the ability to attribute mental states (to oneself and others). Deficits in ToM are thought to have a role in the changes in empathy and interpersonal difficulties that HD patients face. Methods: We conducted a cross sectional study to compare ToM task scores of patients with mild to moderate HD, their relatives (spouse or at-risk first-degree relative with a negative gene test) and controls.Individuals with dementia or depression were excluded. The ToM test battery included Spanish versions of the Reading Mind in the Eyes Test (RMET), Happé's Strange Stories (Social and Physical Stories subtests) and the Hinting Task. Results: The series comprised 12 HD patients, 12 relatives and 12 controls. The HD patients showed lower affective ToM scores than controls (RMET 19 [3.5] vs 23.9 [2.7], p = 0.016). Cognitive ToM tasks scores were lower in HD patients than controls as well (Happé's Social Stories 9 [2.6] vs 13 [1.9], p = 0.001; the Hinting Task 13.6 [3.4] vs 17.5 [4.0], p = 0.009). In the Hinting Task, HD relatives had lower scores in than controls (13 [3.2] vs 17.5 [4.0], p = 0.009) and similar scores to controls in the rest of the battery. Conclusion: The HD patients with mild to moderate disease severity and their relatives show ToM deficits.

scholarly journals Phenomenology Of Delirium: A Cross-Sectional Study Among Referred Cases Of Delirium

2015 ◽  
Vol 3 (2) ◽  
pp. 43-47
Author(s):  
S K Verma ◽  
A K Pandey ◽  
B R Adhikari ◽  
L Mallick
Keyword(s):  
Medical Information ◽  
Rating Scale ◽  
Short Term Memory ◽  
Cross Sectional Study ◽  
Long Term Memory ◽  
Cross Sectional ◽  
Term Memory ◽  
Standard Assessment ◽  
Common Diagnosis ◽  
Available Information

Introduction: Studies from developing countries are few, on phenomenology of Delirium, even though it is a common diagnosis among psychiatric referrals. We studied the phenomenology of delirium in a teaching hospital in western region of Nepal by using standard assessment methods. Aim: The aim of the study was to assess the phenomenological characteristics of delirium based on Delirium Rating Scale-Revised-98 (DRS–R98). Methods: All consecutive patients of delirium who were referred to department of psychiatry for assessment were enrolled over a period of 12 months. Socio-demographic variables and other medical information were collected by using standardized data-collection forms developed by the department of Psychiatry. Assessments were based on all available information obtained from the patients, caregivers, medical staff, and medical records. Results and conclusions: A total of 62 cases were studied out of which 83.9% were male. Mean age of the subjects was 47 years. Mean delirium severity was 21.35 (SD=3.54). Orientation, attention and short term memory was impaired in all of the cases. Long term memory impairment was noted in 98.4% of cases. Sleep wake cycle disturbance was present in 60 (96.8%) cases, perceptual abnormalities in 49 (79%) cases, some form of delusion was present in 19 (30.6%), lability of affect could be appreciated in 27(43.5%). Language, thought process abnormalities and impaired visuo-spatial ability was present in 19 (30.6%), 3 (4.8%) and 13 (21%) cases respectively.J Psychiatric Association of Nepal Vol .3, No.2, 2014, pp: 43-47DOI: http://dx.doi.org/10.3126/jpan.v3i2.12394

Spatiotemporal Gait Characteristics Associated with Cognitive Impairment: A Multicenter Cross-Sectional Study, the Intercontinental “Gait, cOgnitiOn & Decline” Initiative

2018 ◽  
Vol 15 (3) ◽  
pp. 273-282 ◽  
Author(s):  
Olivier Beauchet ◽  
Helena M. Blumen ◽  
Michele L. Callisaya ◽  
Anne-Marie De Cock ◽  
Reto W. Kressig ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Cognitive Status ◽  
Cross Sectional ◽  
Mean Values ◽  
Gait Characteristics ◽  
Moderate Dementia ◽  
Gait Parameters ◽  
Gait Disturbances

Background: The study aims to determine the spatiotemporal gait parameters and/or their combination(s) that best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia, regardless of the etiology of cognitive impairment. Methods: A total of 2099 participants (1015 CHI, 478 patients with MCI, 331 patients with mild dementia and 275 with moderate dementia) were selected from the intercontinental “Gait, cOgnitiOn & Decline” (GOOD) initiative, which merged different databases from seven cross-sectional studies. Mean values and coefficients of variation (CoV) of spatiotemporal gait parameters were recorded during usual walking with the GAITRite® system. Results: The severity of cognitive impairment was associated with worse performance on all gait parameters. Stride velocity had the strongest association with cognitive impairment, regardless of cognitive status. High mean value and CoV of stride length characterized moderate dementia, whereas increased CoV of stride time was specific to MCI status. Conclusion: The findings support the existence of specific cognitive impairment-related gait disturbances with differences related to stages of cognitive impairment, which may be used to screen individuals with cognitive impairment.

Sign in / Sign up

Export Citation Format

Share Document