Comparison of clinicopathological traits and prognostic factors of hepatocellular carcinoma with and without cirrhotic background

2020 ◽  
Vol 41 (11) ◽  
pp. 1576-1582
Author(s):  
Jian Hu ◽  
Zhi-Qing Zhang ◽  
Wei Zhu ◽  
Zhen-Ru Wu ◽  
Yu You ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Animal Model ◽  
Risk Factor ◽  
Prognostic Factors ◽  
Independent Risk Factor ◽  
Weight Ratio ◽  
The Difference ◽  
Hepatic Portal ◽  
Stratified Analysis ◽  
Glutamyl Transpeptidase

Abstract The difference of the patients bearing hepatocellular carcinoma (HCC) with and without cirrhosis at clinical level has not been completely determined. This study compared their differences in clinicopathological traits and prognostic factors for relapse-free survival (RFS) and overall survival (OS). Animal model was established to validate the result of clinical observation. As a result, 82 patients bearing HCC with no cirrhosis (HCC-NC) and 146 patients bearing HCC with cirrhosis (HCC-C) were included. HCC-NC exhibited shorter prothrombin time and higher plasma albumin than HCC-C. In HCC-NC, satellite nodule was an independent risk factor for OS, and high γ-glutamyl transpeptidase was an independent risk factor for RFS. In HCC-C, female sex was an independent risk factor for OS. Stratified analysis showed the OS and RFS of HCC-NC were better than HCC-C in conditions like without cancer embolus (in the portal vein or bile duct), without lymphadenopathy in hepatic portal, without satellite nodule and with small or high-differentiated tumor. Animal model analysis showed HCC-NC had a higher liver/body weight ratio, less tumor count and smaller max tumor volume than HCC-C. In conclusion, clinicopathological traits and risk factors influencing postoperative OS and RFS differed between patients with HCC-C and HCC-NC.

scholarly journals Prognostic value of preoperative inflammatory markers in patients with hepatocellular carcinoma underwent curative resection

2021 ◽  
Author(s):  
Wenlong Wu ◽  
Quancheng Wang ◽  
Dandan Han ◽  
Jianhui Li ◽  
Ye Nie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Inflammatory Markers ◽  
Curative Resection ◽  
Information Criterion ◽  
Gamma Glutamyl Transpeptidase ◽  
Roc Curve Analysis ◽  
Lymphocyte Ratio ◽  
Kaplan Meier ◽  
Glutamyl Transpeptidase

Abstract Background: The prognosis of hepatocellular carcinoma (HCC) is not optimistic. Our study focused on present inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), gamma-glutamyl transpeptidase-to-platelet ratio (GPR), aspartate aminotransferase-to-lymphocyte ratio (ALR) and fibrinogen-to-albumin ratio (FAR), and aimed to explore their optimal combination for the prognosis of HCC after resection.Methods: 347 HCC patients with curative resection were enrolled. The optimal cutoff values of the inflammatory markers were calculated using receiver operating characteristic (ROC) curve analysis, and used to divide patients into two groups whose differences were compared by Kaplan-Meier analysis. Cox univariate and multivariate analysis were used to analyze the independent prognostic inflammatory markers. c2 test was chosen to determine the relationship between independent prognostic inflammatory markers and clinicopathological features. We created the combined scoring models and evaluated them by Cox univariate and multivariate methods. The concordance index (C-index), Akaike information criterion (AIC) and likelihood ratio were calculated to compare the models. The selected optimal inflammatory markers and their combinations were tested in different stages of HCC by Kaplan-Meier analysis.Results: ALR and GPR were independent prognostic factors for DFS; ALR, PLR, and GPR were independent prognostic factors for OS. The proposed GPR and ALR-GPR-PLR score models were independent predictors for DFS and OS, respectively.Conclusion: The preoperative GPR and ALR-GPR-PLR score models were independent predictors for DFS and OS, respectively, and performed well in stratifying patients with HCC. The higher score in the model, the worse the prognosis was.

Impaired Value of 99m Tc-GSA Scintigraphy as an Independent Risk Factor for Posthepatectomy Liver Failure in Patients with Hepatocellular Carcinoma

2018 ◽  
Vol 59 (1-2) ◽  
pp. 12-22 ◽  
Author(s):  
Ikuo Nakamura ◽  
Yuji Iimuro ◽  
Seikan Hai ◽  
Yuichi  Kondo ◽  
Etsuro Hatano ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Serum Albumin ◽  
Liver Failure ◽  
Clinical Management ◽  
Independent Risk Factor ◽  
Liver Volume ◽  
Invasive Treatment ◽  
Noninvasive Treatment ◽  
Posthepatectomy Liver Failure

Background: Posthepatectomy liver failure (PHLF) was recently defined with the corresponding recommendations as follows: grade A, no change in clinical management; grade B, clinical management with noninvasive treatment; and grade C, clinical management with invasive treatment. In this study, we identified the risk factors for grade B and C PHLF in patients with hepatocellular carcinoma (HCC). Methods: Of 339 HCC patients who underwent curative hepatic resection, 218 were included for analysis. The LHL15 index (uptake ratio of the liver to that of the liver and heart at 15 min) was measured by 99m Tc-GSA (99m technetium-labelled galactosyl human serum albumin); remnant LHL15 was calculated as LHL15 × [1 − (resected liver weight − tumor volume)/whole liver volume without tumor]. Results: A total of 163 patients were classified as having no PHLF, whereas 17, 37, and 1 patient had PHLF grade A, B, and C, respectively. There were significant differences in indocyanine green R15, serum albumin, prothrombin time, Child-Pugh classification, LHL15 and remnant LHL15 between patients with grades B/C PHLF and patients with grade A or no PHLF. Only remnant LHL15 was identified as an independent risk factor for grades B/C PHLF (p = 0.023), with a cut-off value of 0.755. Conclusions: Remnant LHL15 was an independent risk factor for grades B/C PHLF. Patients with impaired remnant LHL15 value of <0.755 should be carefully monitored for PHLF.

Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma

2016 ◽  
Vol 84 ◽  
pp. 1858-1864 ◽  
Author(s):  
Fangtian Fan ◽  
Hongyan Wu ◽  
Zhaoguo Liu ◽  
Xianbang Hou ◽  
Wenxin Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Curative Resection ◽  
Independent Risk Factor

scholarly journals Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study

2011 ◽  
Vol 105 (9) ◽  
pp. 1430-1435 ◽  
Author(s):  
W-P Koh ◽  
K Robien ◽  
R Wang ◽  
S Govindarajan ◽  
J-M Yuan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Health Study ◽  
Singapore Chinese
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